AutismKB 2.0

Annotation Detail for NHSL1


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Basic Information Top
Gene Symbol:NHSL1 ( C6orf63,KIAA1357 )
Gene Full Name: NHS-like 1
Band: 6q24.1
Quick LinksEntrez ID:57224; OMIM: NA; Uniprot ID:NHSL1_HUMAN; ENSEMBL ID: ENSG00000135540; HGNC ID: 21021
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst0 / 623190 
fetus27 / 56401247
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult41 / 193912121
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor1 / 9417810
cervical tumor0 / 343660 
chondrosarcoma2 / 8282324
colorectal tumor2 / 11424617
esophageal tumor0 / 172900 
gastrointestinal tumor4 / 11936933
germ cell tumor2 / 2638457
glioma4 / 10688337
head and neck tumor1 / 1363027
kidney tumor3 / 6895943
leukemia0 / 958420 
liver tumor2 / 9635920
lung tumor1 / 1031279
lymphoma1 / 7175513
non-neoplasia1 / 9725010
normal74 / 336030722
ovarian tumor1 / 7668213
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma2 / 4635643
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites4 / 4001599
bladder0 / 297570 
blood0 / 1234780 
bone3 / 7165541
bone marrow0 / 488010 
brain26 / 110098923
cervix0 / 481710 
connective tissue1 / 1492556
ear0 / 162120 
embryonic tissue2 / 2157229
esophagus0 / 202090 
eye4 / 21105418
heart0 / 896260 
intestine14 / 23447259
kidney9 / 21177742
larynx0 / 241450 
liver5 / 20774324
lung10 / 33697429
lymph1 / 4427022
lymph node0 / 916100 
mammary gland1 / 1532716
mouth0 / 670520 
muscle1 / 1077159
nerve0 / 157680 
ovary3 / 10205129
pancreas4 / 21481218
parathyroid1 / 2053948
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta5 / 28082517
prostate0 / 1893450 
salivary gland0 / 201550 
skin3 / 21057414
spleen0 / 539520 
stomach2 / 9661920
testis1 / 3304423
thymus0 / 811310 
thyroid1 / 4747321
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus0 / 2328780 
vascular0 / 517800 
Microarray in BioGPS Top
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P387184
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.68 ± 0.41
Basal Forebrain4.54 ± 0.39
Basal Part of Pons3.37 ± 0.42
Cerebellar Cortex4.69 ± 0.5
Cerebellar Nuclei3.82 ± 0.45
Claustrum4.21 ± 0.66
Epithalamus4.66 ± 0.61
Frontal Lobe4.3 ± 0.7
Globus Pallidus6.11 ± 0.77
Hypothalamus4.13 ± 0.47
Insula4.43 ± 0.49
Limbic Lobe5.03 ± 0.71
Mesencephalon4.72 ± 0.66
Myelencephalon4.59 ± 0.75
Occipital Lobe4.64 ± 0.86
Parietal Lobe4.4 ± 0.84
Pontine Tegmentum4.82 ± 0.54
Striatum5.1 ± 0.72
Subthalamus3.69 ± 0.93
Temporal Lobe4.41 ± 0.61
Thalamus4.91 ± 0.56
White Matter3.64 ± 0.63
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Nhsl1CBCerebellum20.67
31.71
Nhsl1CTXCerebral cortex11.23
8.6
Nhsl1HIPHippocampal region24.6
44.55
Nhsl1HPFHippocampal formation20.6
31.87
Nhsl1HYHypothalamus3.98
3.23
Nhsl1LSXLateral septal complex2.7
2.21
Nhsl1MBMidbrain6.18
6.38
Nhsl1MYMedulla15.67
16.56
Nhsl1OLFOlfactory bulb31.09
23.15
Nhsl1PPons10.37
12.11
Nhsl1PALPallidum6.33
5.42
Nhsl1RHPRetrohippocampal region10.33
8.27
Nhsl1sAMYStriatum-like amygdalar nuclei16.11
13.78
Nhsl1STRStriatum5.46
4.23
Nhsl1STRdStriatum dorsal region3.57
2.9
Nhsl1STRvStriatum ventral region7.31
4.45
Nhsl1THThalamus13.25
12.47
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00501206 27 220 246 ELASGTGQDDADGHSVYTPDHYSTLGR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018