AutismKB 2.0

Annotation Detail for MRS2


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Basic Information Top
Gene Symbol:MRS2 ( HPT,MGC78523,MRS2L )
Gene Full Name: MRS2 magnesium homeostasis factor homolog (S. cerevisiae)
Band: 6p22.3
Quick LinksEntrez ID:57380; OMIM: NA; Uniprot ID:MRS2_HUMAN; ENSEMBL ID: ENSG00000124532; HGNC ID: 13785
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body7 / 7076198
blastocyst6 / 6231996
fetus31 / 56401254
neonate0 / 310970 
infant0 / 236200 
juvenile5 / 5555689
adult82 / 193912142
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor1 / 9417810
cervical tumor3 / 3436687
chondrosarcoma4 / 8282348
colorectal tumor2 / 11424617
esophageal tumor2 / 17290115
gastrointestinal tumor5 / 11936941
germ cell tumor33 / 263845125
glioma8 / 10688374
head and neck tumor3 / 13630222
kidney tumor4 / 6895958
leukemia4 / 9584241
liver tumor7 / 9635972
lung tumor3 / 10312729
lymphoma2 / 7175527
non-neoplasia2 / 9725020
normal168 / 336030749
ovarian tumor4 / 7668252
pancreatic tumor2 / 10461619
primitive neuroectodermal tumor of the CNS9 / 12568071
prostate cancer2 / 10268019
retinoblastoma2 / 4635643
skin tumor3 / 12494924
soft tissue/muscle tissue tumor5 / 12519139
uterine tumor4 / 9025744
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites2 / 4001549
bladder2 / 2975767
blood0 / 1234780 
bone3 / 7165541
bone marrow1 / 4880120
brain49 / 110098944
cervix3 / 4817162
connective tissue2 / 14925513
ear2 / 16212123
embryonic tissue20 / 21572292
esophagus2 / 2020998
eye12 / 21105456
heart6 / 8962666
intestine8 / 23447234
kidney15 / 21177770
larynx0 / 241450 
liver7 / 20774333
lung15 / 33697444
lymph1 / 4427022
lymph node11 / 91610120
mammary gland1 / 1532716
mouth0 / 670520 
muscle11 / 107715102
nerve0 / 157680 
ovary4 / 10205139
pancreas10 / 21481246
parathyroid13 / 20539632
pharynx0 / 413280 
pituitary gland1 / 1658560
placenta14 / 28082549
prostate2 / 18934510
salivary gland0 / 201550 
skin4 / 21057418
spleen1 / 5395218
stomach3 / 9661931
testis11 / 33044233
thymus0 / 811310 
thyroid3 / 4747363
tonsil1 / 1699958
trachea2 / 5241338
umbilical cord0 / 136800 
uterus8 / 23287834
vascular2 / 5178038
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 218538_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts97.45
Adipocyte8.7
AdrenalCortex13
Adrenalgland8.15
Amygdala9.1
Appendix11.35
AtrioventricularNode11.15
BDCA4+_DentriticCells26.05
Bonemarrow10.3
BronchialEpithelialCells41.25
CD105+_Endothelial12.35
CD14+_Monocytes23.45
CD19+_BCells(neg._sel.)10.8
CD33+_Myeloid16.45
CD34+25
CD4+_Tcells9.5
CD56+_NKCells10.55
CD71+_EarlyErythroid8.9
CD8+_Tcells9.75
CardiacMyocytes19.8
Caudatenucleus8.2
Cerebellum7.35
CerebellumPeduncles11.1
CiliaryGanglion9.8
CingulateCortex9.15
Colorectaladenocarcinoma11.7
DorsalRootGanglion8.6
FetalThyroid9.1
Fetalbrain8.25
Fetalliver8
Fetallung6.5
GlobusPallidus7.25
Heart16.7
Hypothalamus8.5
Kidney8.5
Leukemia_chronicMyelogenousK-56219.2
Leukemia_promyelocytic-HL-6012.2
Leukemialymphoblastic(MOLT-4)7.05
Liver14.25
Lung9.55
Lymphnode7.35
Lymphoma_burkitts(Daudi)12.1
Lymphoma_burkitts(Raji)14.75
MedullaOblongata7.35
OccipitalLobe7.8
OlfactoryBulb6.5
Ovary7.1
Pancreas7.95
PancreaticIslet10.1
ParietalLobe10.3
Pituitary10.5
Placenta11.35
Pons8.95
PrefrontalCortex10.2
Prostate10.3
Salivarygland7.8
SkeletalMuscle15.75
Skin9.5
SmoothMuscle9.8
Spinalcord8.8
SubthalamicNucleus8.6
SuperiorCervicalGanglion16.2
TemporalLobe8.5
Testis7.65
TestisGermCell6.75
TestisIntersitial7.7
TestisLeydigCell9.4
TestisSeminiferousTubule7.5
Thalamus9.75
Thymus6.45
Thyroid13.25
Tongue10.95
Tonsil9
Trachea7.25
TrigeminalGanglion12.7
Uterus8.8
UterusCorpus9.75
WholeBlood9.15
Wholebrain6.9
colon18.4
pineal_day19.92
pineal_night15.56
retina10.85
small_intestine10.35
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_13153_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.79 ± 0.32
Basal Forebrain5.77 ± 0.21
Basal Part of Pons5.74 ± 0.32
Cerebellar Cortex6.03 ± 0.22
Cerebellar Nuclei6.03 ± 0.46
Claustrum5.42 ± 0.62
Epithalamus5.59 ± 0.39
Frontal Lobe5.74 ± 0.35
Globus Pallidus5.45 ± 0.24
Hypothalamus5.72 ± 0.34
Insula5.57 ± 0.38
Limbic Lobe5.6 ± 0.42
Mesencephalon5.72 ± 0.39
Myelencephalon5.68 ± 0.41
Occipital Lobe5.72 ± 0.3
Parietal Lobe5.87 ± 0.39
Pontine Tegmentum5.77 ± 0.43
Striatum5.43 ± 0.42
Subthalamus5.86 ± 0.35
Temporal Lobe5.72 ± 0.35
Thalamus5.73 ± 0.39
White Matter5.63 ± 0.21
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Mrs2lCBCerebellum29.57
45.83
Mrs2lCTXCerebral cortex54.55
41.93
Mrs2lHIPHippocampal region38.32
45.93
Mrs2lHPFHippocampal formation45
45.49
Mrs2lHYHypothalamus17.57
13.66
Mrs2lLSXLateral septal complex13
8.71
Mrs2lMBMidbrain32.91
31.39
Mrs2lMYMedulla51.92
58.75
Mrs2lOLFOlfactory bulb47.44
36.1
Mrs2lPPons39.73
41.87
Mrs2lPALPallidum22.13
20.62
Mrs2lRHPRetrohippocampal region57.98
46.13
Mrs2lsAMYStriatum-like amygdalar nuclei24.23
17.85
Mrs2lSTRStriatum19.79
14.43
Mrs2lSTRdStriatum dorsal region18.52
13.87
Mrs2lSTRvStriatum ventral region23.37
15.66
Mrs2lTHThalamus53.2
48.61
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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