AutismKB 2.0

Annotation Detail for PTGS1


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Basic Information Top
Gene Symbol:PTGS1 ( COX1,COX3,PCOX1,PGG/HS,PGHS-1,PGHS1,PHS1,PTGHS )
Gene Full Name: prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
Band: 9q33.2
Quick LinksEntrez ID:5742; OMIM: 176805; Uniprot ID:PGH1_HUMAN; ENSEMBL ID: ENSG00000095303; HGNC ID: 9604
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst0 / 623190 
fetus16 / 56401228
neonate16 / 31097514
infant0 / 236200 
juvenile1 / 5555617
adult66 / 193912134
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma18 / 82823217
colorectal tumor1 / 1142468
esophageal tumor1 / 1729057
gastrointestinal tumor2 / 11936916
germ cell tumor2 / 2638457
glioma1 / 1068839
head and neck tumor6 / 13630244
kidney tumor1 / 6895914
leukemia2 / 9584220
liver tumor1 / 9635910
lung tumor1 / 1031279
lymphoma0 / 717550 
non-neoplasia5 / 9725051
normal131 / 336030738
ovarian tumor3 / 7668239
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor1 / 1249498
soft tissue/muscle tissue tumor2 / 12519115
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites0 / 400150 
bladder0 / 297570 
blood2 / 12347816
bone0 / 716550 
bone marrow0 / 488010 
brain30 / 110098927
cervix4 / 4817183
connective tissue14 / 14925593
ear0 / 162120 
embryonic tissue1 / 2157224
esophagus1 / 2020949
eye4 / 21105418
heart3 / 8962633
intestine4 / 23447217
kidney4 / 21177718
larynx0 / 241450 
liver1 / 2077434
lung11 / 33697432
lymph0 / 442700 
lymph node5 / 9161054
mammary gland1 / 1532716
mouth7 / 67052104
muscle5 / 10771546
nerve1 / 1576863
ovary4 / 10205139
pancreas2 / 2148129
parathyroid0 / 205390 
pharynx1 / 4132824
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate13 / 18934568
salivary gland0 / 201550 
skin22 / 210574104
spleen4 / 5395274
stomach4 / 9661941
testis4 / 33044212
thymus1 / 8113112
thyroid0 / 474730 
tonsil1 / 1699958
trachea4 / 5241376
umbilical cord0 / 136800 
uterus3 / 23287812
vascular23 / 51780444
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 215813_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts32.9
Adipocyte121.15
AdrenalCortex8.2
Adrenalgland6.4
Amygdala7.95
Appendix30.75
AtrioventricularNode5.8
BDCA4+_DentriticCells63.1
Bonemarrow8.1
BronchialEpithelialCells7.3
CD105+_Endothelial46.9
CD14+_Monocytes182.9
CD19+_BCells(neg._sel.)91.9
CD33+_Myeloid184.15
CD34+216
CD4+_Tcells5.8
CD56+_NKCells8.9
CD71+_EarlyErythroid15.55
CD8+_Tcells5.75
CardiacMyocytes407.2
Caudatenucleus6.9
Cerebellum7.8
CerebellumPeduncles8.35
CiliaryGanglion5.5
CingulateCortex7.25
Colorectaladenocarcinoma7.25
DorsalRootGanglion7.7
FetalThyroid6.5
Fetalbrain6.95
Fetalliver9.05
Fetallung5.8
GlobusPallidus5.65
Heart9.75
Hypothalamus12.75
Kidney6.3
Leukemia_chronicMyelogenousK-5629.2
Leukemia_promyelocytic-HL-606.15
Leukemialymphoblastic(MOLT-4)5.3
Liver10.45
Lung19.5
Lymphnode6.55
Lymphoma_burkitts(Daudi)9.55
Lymphoma_burkitts(Raji)11.05
MedullaOblongata6.6
OccipitalLobe6.85
OlfactoryBulb5.5
Ovary4.05
Pancreas5.95
PancreaticIslet7.9
ParietalLobe7.95
Pituitary14.85
Placenta9.5
Pons7.3
PrefrontalCortex9.1
Prostate15.75
Salivarygland6.2
SkeletalMuscle9.45
Skin6.4
SmoothMuscle1529.85
Spinalcord12.85
SubthalamicNucleus5.1
SuperiorCervicalGanglion20.65
TemporalLobe6.2
Testis8
TestisGermCell5.95
TestisIntersitial5.5
TestisLeydigCell9.55
TestisSeminiferousTubule6
Thalamus7.2
Thymus6
Thyroid9.5
Tongue10.9
Tonsil7.45
Trachea6.4
TrigeminalGanglion30
Uterus9.6
UterusCorpus11.45
WholeBlood97.9
Wholebrain6.75
colon41.2
pineal_day168.02
pineal_night290.58
retina9.475
small_intestine15.85
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P216966
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala1.75 ± 0.92
Basal Forebrain1.17 ± 0.36
Basal Part of Pons1.47 ± 0.82
Cerebellar Cortex1.03 ± 0.53
Cerebellar Nuclei1.94 ± 0.75
Claustrum1.96 ± 0.72
Epithalamus1.37 ± 0.85
Frontal Lobe1.14 ± 0.76
Globus Pallidus2.76 ± 0.92
Hypothalamus1.43 ± 0.79
Insula1.09 ± 0.54
Limbic Lobe1.28 ± 0.92
Mesencephalon1.41 ± 0.77
Myelencephalon1.34 ± 0.75
Occipital Lobe1.51 ± 0.88
Parietal Lobe1.63 ± 0.93
Pontine Tegmentum1.32 ± 0.83
Striatum1.34 ± 0.68
Subthalamus1.37 ± 0.65
Temporal Lobe1.19 ± 0.68
Thalamus1.21 ± 0.75
White Matter2.32 ± 1.07
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Ptgs1CBCerebellum11.09
13.03
Ptgs1CTXCerebral cortex14.93
12.61
Ptgs1HIPHippocampal region9.44
10.13
Ptgs1HPFHippocampal formation8.3
7.99
Ptgs1HYHypothalamus1.63
1.27
Ptgs1LSXLateral septal complex2.62
1.93
Ptgs1MBMidbrain7.79
8.28
Ptgs1MYMedulla15.08
21.33
Ptgs1OLFOlfactory bulb9.87
8.67
Ptgs1PPons9.92
12.15
Ptgs1PALPallidum13.06
13.53
Ptgs1RHPRetrohippocampal region6.82
5.53
Ptgs1sAMYStriatum-like amygdalar nuclei5.6
4.15
Ptgs1STRStriatum4.93
3.63
Ptgs1STRdStriatum dorsal region4.16
3.07
Ptgs1STRvStriatum ventral region7.29
4.89
Ptgs1THThalamus1.18
1.18
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00078555 27 536 562 TCPYVSFRVPDASQDDGPAVERPSTEL Peptide Atlas
PGH1_HUMAN_49 5 49 53 FGLDR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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