AutismKB 2.0

Annotation Detail for PTGS2


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Basic Information Top
Gene Symbol:PTGS2 ( COX-2,COX2,GRIPGHS,PGG/HS,PGHS-2,PHS-2,hCox-2 )
Gene Full Name: prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
Band: 1q31.1
Quick LinksEntrez ID:5743; OMIM: 600262; Uniprot ID:PGH2_HUMAN; ENSEMBL ID: ENSG00000073756; HGNC ID: 9605
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body2 / 7076128
blastocyst0 / 623190 
fetus2 / 5640123
neonate0 / 310970 
infant1 / 2362042
juvenile1 / 5555617
adult57 / 193912129
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma3 / 17475171
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma5 / 8282360
colorectal tumor3 / 11424626
esophageal tumor1 / 1729057
gastrointestinal tumor4 / 11936933
germ cell tumor0 / 2638450 
glioma1 / 1068839
head and neck tumor2 / 13630214
kidney tumor0 / 689590 
leukemia3 / 9584231
liver tumor2 / 9635920
lung tumor4 / 10312738
lymphoma0 / 717550 
non-neoplasia1 / 9725010
normal103 / 336030730
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor1 / 1249498
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood31 / 123478251
bone3 / 7165541
bone marrow3 / 4880161
brain10 / 11009899
cervix4 / 4817183
connective tissue5 / 14925533
ear0 / 162120 
embryonic tissue2 / 2157229
esophagus1 / 2020949
eye1 / 2110544
heart0 / 896260 
intestine3 / 23447212
kidney2 / 2117779
larynx0 / 241450 
liver2 / 2077439
lung11 / 33697432
lymph0 / 442700 
lymph node0 / 916100 
mammary gland2 / 15327113
mouth0 / 670520 
muscle4 / 10771537
nerve1 / 1576863
ovary0 / 1020510 
pancreas7 / 21481232
parathyroid0 / 205390 
pharynx1 / 4132824
pituitary gland0 / 165850 
placenta5 / 28082517
prostate12 / 18934563
salivary gland0 / 201550 
skin3 / 21057414
spleen1 / 5395218
stomach4 / 9661941
testis0 / 3304420 
thymus0 / 811310 
thyroid1 / 4747321
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord1 / 1368073
uterus1 / 2328784
vascular22 / 51780424
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 204748_at
Cell line Expression level Expression bar
721_B_lymphoblasts7.4
Adipocyte6.65
AdrenalCortex10.4
Adrenalgland6.2
Amygdala6.9
Appendix10.45
AtrioventricularNode7.85
BDCA4+_DentriticCells39.6
Bonemarrow7.6
BronchialEpithelialCells659.3
CD105+_Endothelial7
CD14+_Monocytes104.4
CD19+_BCells(neg._sel.)7.1
CD33+_Myeloid186.95
CD34+19.6
CD4+_Tcells6.85
CD56+_NKCells7.9
CD71+_EarlyErythroid6.8
CD8+_Tcells6.15
CardiacMyocytes21.4
Caudatenucleus6.35
Cerebellum5.9
CerebellumPeduncles8.45
CiliaryGanglion8.25
CingulateCortex7.4
Colorectaladenocarcinoma6.85
DorsalRootGanglion7.15
FetalThyroid8.05
Fetalbrain6.8
Fetalliver6.1
Fetallung38.25
GlobusPallidus5.7
Heart11.3
Hypothalamus7.05
Kidney6.2
Leukemia_chronicMyelogenousK-5626.15
Leukemia_promyelocytic-HL-605.95
Leukemialymphoblastic(MOLT-4)5.3
Liver10.45
Lung7.7
Lymphnode10.35
Lymphoma_burkitts(Daudi)9.05
Lymphoma_burkitts(Raji)10.6
MedullaOblongata6.35
OccipitalLobe6.35
OlfactoryBulb5.7
Ovary5
Pancreas5.9
PancreaticIslet399.8
ParietalLobe8.65
Pituitary8.4
Placenta7.4
Pons7.5
PrefrontalCortex9.55
Prostate34.1
Salivarygland5.75
SkeletalMuscle13.2
Skin7.2
SmoothMuscle1260.2
Spinalcord7.7
SubthalamicNucleus7.5
SuperiorCervicalGanglion10.55
TemporalLobe6.55
Testis5.9
TestisGermCell5.6
TestisIntersitial5.9
TestisLeydigCell7.45
TestisSeminiferousTubule6
Thalamus7.25
Thymus5.25
Thyroid8.1
Tongue7.7
Tonsil6.95
Trachea6.05
TrigeminalGanglion8.55
Uterus6.15
UterusCorpus8.4
WholeBlood121.95
Wholebrain5.85
colon7.1
pineal_day8.58
pineal_night10.54
retina21.15
small_intestine6.8
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_527_PI416408490
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala3.93 ± 0.95
Basal Forebrain3.42 ± 0.35
Basal Part of Pons3.43 ± 0.94
Cerebellar Cortex3.06 ± 0.53
Cerebellar Nuclei3.58 ± 0.42
Claustrum5.25 ± 0.4
Epithalamus3.75 ± 0.74
Frontal Lobe3.9 ± 0.71
Globus Pallidus3.8 ± 0.92
Hypothalamus3.6 ± 0.95
Insula4.08 ± 0.52
Limbic Lobe3.53 ± 0.71
Mesencephalon3.92 ± 0.85
Myelencephalon3.72 ± 0.69
Occipital Lobe3.52 ± 0.73
Parietal Lobe3.81 ± 0.81
Pontine Tegmentum3.79 ± 0.88
Striatum2.89 ± 1.2
Subthalamus3.46 ± 0.69
Temporal Lobe3.97 ± 0.56
Thalamus3.62 ± 0.62
White Matter2.78 ± 0.56
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Ptgs2CBCerebellum20.12
29.91
Ptgs2CTXCerebral cortex32.11
29.8
Ptgs2HIPHippocampal region33.33
58.96
Ptgs2HPFHippocampal formation24.69
38.03
Ptgs2HYHypothalamus5.38
4.68
Ptgs2LSXLateral septal complex4.11
4.85
Ptgs2MBMidbrain5.02
6.43
Ptgs2MYMedulla4.62
6.28
Ptgs2OLFOlfactory bulb36.93
38.64
Ptgs2PPons5.92
7.22
Ptgs2PALPallidum3.55
3.29
Ptgs2RHPRetrohippocampal region11.42
12.24
Ptgs2sAMYStriatum-like amygdalar nuclei7.33
6.14
Ptgs2STRStriatum4.78
4.15
Ptgs2STRdStriatum dorsal region2.59
2.08
Ptgs2STRvStriatum ventral region10.7
8.68
Ptgs2THThalamus4.22
4.92
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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