AutismKB 2.0

Annotation Detail for INTS2


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Basic Information Top
Gene Symbol:INTS2 ( INT2,KIAA1287 )
Gene Full Name: integrator complex subunit 2
Band: 17q23.2
Quick LinksEntrez ID:57508; OMIM: 611346; Uniprot ID:INT2_HUMAN; ENSEMBL ID: ENSG00000108506; HGNC ID: 29241
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body2 / 7076128
blastocyst4 / 6231964
fetus3 / 5640125
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult14 / 19391217
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor1 / 9417810
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor1 / 1142468
esophageal tumor1 / 1729057
gastrointestinal tumor1 / 1193698
germ cell tumor4 / 26384515
glioma1 / 1068839
head and neck tumor2 / 13630214
kidney tumor0 / 689590 
leukemia5 / 9584252
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia1 / 9725010
normal36 / 336030710
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS5 / 12568039
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor1 / 1249498
soft tissue/muscle tissue tumor2 / 12519115
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites0 / 400150 
bladder0 / 297570 
blood3 / 12347824
bone0 / 716550 
bone marrow0 / 488010 
brain21 / 110098919
cervix0 / 481710 
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue8 / 21572237
esophagus1 / 2020949
eye1 / 2110544
heart0 / 896260 
intestine1 / 2344724
kidney0 / 2117770 
larynx0 / 241450 
liver0 / 2077430 
lung6 / 33697417
lymph0 / 442700 
lymph node3 / 9161032
mammary gland3 / 15327119
mouth2 / 6705229
muscle3 / 10771527
nerve0 / 157680 
ovary0 / 1020510 
pancreas2 / 2148129
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate0 / 1893450 
salivary gland1 / 2015549
skin5 / 21057423
spleen0 / 539520 
stomach1 / 9661910
testis4 / 33044212
thymus4 / 8113149
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus3 / 23287812
vascular0 / 517800 
Microarray in BioGPS Top
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_9585_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.46 ± 0.36
Basal Forebrain5.63 ± 0.17
Basal Part of Pons5.29 ± 0.23
Cerebellar Cortex5.71 ± 0.26
Cerebellar Nuclei5.6 ± 0.62
Claustrum5.54 ± 0.5
Epithalamus6.01 ± 0.35
Frontal Lobe5.38 ± 0.38
Globus Pallidus5.67 ± 0.42
Hypothalamus5.82 ± 0.22
Insula5.29 ± 0.54
Limbic Lobe5.37 ± 0.43
Mesencephalon5.54 ± 0.42
Myelencephalon5.53 ± 0.43
Occipital Lobe5.69 ± 0.34
Parietal Lobe5.48 ± 0.38
Pontine Tegmentum5.51 ± 0.46
Striatum5.53 ± 0.36
Subthalamus5.47 ± 0.57
Temporal Lobe5.51 ± 0.35
Thalamus5.5 ± 0.31
White Matter6.44 ± 0.33
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Ints2CBCerebellum1.77
1.87
Ints2CTXCerebral cortex3.26
2.12
Ints2HIPHippocampal region2.18
1.77
Ints2HPFHippocampal formation1.95
1.46
Ints2HYHypothalamus0.8
0.51
Ints2LSXLateral septal complex1.37
0.84
Ints2MBMidbrain1.32
1.13
Ints2MYMedulla4.18
3.92
Ints2OLFOlfactory bulb5.24
4.85
Ints2PPons2.29
2.05
Ints2PALPallidum1.47
0.96
Ints2RHPRetrohippocampal region1.55
1.03
Ints2sAMYStriatum-like amygdalar nuclei1.11
0.63
Ints2STRStriatum0.98
0.59
Ints2STRdStriatum dorsal region0.88
0.55
Ints2STRvStriatum ventral region0.98
0.52
Ints2THThalamus1.89
1.18
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00096582 25 288 312 NEACEDGVSDLVCFVSGLLLGTNAK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018