AutismKB 2.0

Annotation Detail for ALPK3


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Basic Information Top
Gene Symbol:ALPK3 ( FLJ12881,FLJ21176,KIAA1330,MAK,MIDORI )
Gene Full Name: alpha-kinase 3
Band: 15q25.3
Quick LinksEntrez ID:57538; OMIM: NA; Uniprot ID:ALPK3_HUMAN; ENSEMBL ID: ENSG00000136383; HGNC ID: 17574
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body3 / 7076142
blastocyst0 / 623190 
fetus21 / 56401237
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult41 / 193912121
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma2 / 8282324
colorectal tumor3 / 11424626
esophageal tumor0 / 172900 
gastrointestinal tumor3 / 11936925
germ cell tumor3 / 26384511
glioma0 / 1068830 
head and neck tumor1 / 1363027
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal77 / 336030722
ovarian tumor2 / 7668226
pancreatic tumor2 / 10461619
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer1 / 1026809
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor2 / 9025722
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder1 / 2975733
blood0 / 1234780 
bone0 / 716550 
bone marrow0 / 488010 
brain11 / 11009899
cervix0 / 481710 
connective tissue2 / 14925513
ear0 / 162120 
embryonic tissue3 / 21572213
esophagus0 / 202090 
eye6 / 21105428
heart4 / 8962644
intestine7 / 23447229
kidney4 / 21177718
larynx0 / 241450 
liver1 / 2077434
lung7 / 33697420
lymph0 / 442700 
lymph node0 / 916100 
mammary gland0 / 1532710 
mouth1 / 6705214
muscle12 / 107715111
nerve1 / 1576863
ovary0 / 1020510 
pancreas13 / 21481260
parathyroid1 / 2053948
pharynx1 / 4132824
pituitary gland0 / 165850 
placenta2 / 2808257
prostate2 / 18934510
salivary gland0 / 201550 
skin0 / 2105740 
spleen1 / 5395218
stomach3 / 9661931
testis2 / 3304426
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord2 / 13680146
uterus4 / 23287817
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 214846_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts4.45
Adipocyte3.5
AdrenalCortex3.75
Adrenalgland3
Amygdala3.7
Appendix3.55
AtrioventricularNode2.8
BDCA4+_DentriticCells4
Bonemarrow3.5
BronchialEpithelialCells3.55
CD105+_Endothelial3.6
CD14+_Monocytes3.8
CD19+_BCells(neg._sel.)3.85
CD33+_Myeloid4.6
CD34+4.5
CD4+_Tcells3.95
CD56+_NKCells4.3
CD71+_EarlyErythroid3.35
CD8+_Tcells3.5
CardiacMyocytes4.7
Caudatenucleus3.15
Cerebellum2.9
CerebellumPeduncles4.05
CiliaryGanglion2.55
CingulateCortex3.65
Colorectaladenocarcinoma3.55
DorsalRootGanglion2.75
FetalThyroid3.45
Fetalbrain3.55
Fetalliver3.05
Fetallung2.95
GlobusPallidus2.65
Heart4.55
Hypothalamus3.9
Kidney2.9
Leukemia_chronicMyelogenousK-5623.2
Leukemia_promyelocytic-HL-603.1
Leukemialymphoblastic(MOLT-4)2.9
Liver4.7
Lung3.95
Lymphnode3.05
Lymphoma_burkitts(Daudi)4.5
Lymphoma_burkitts(Raji)4.95
MedullaOblongata3.25
OccipitalLobe3.2
OlfactoryBulb2.85
Ovary2.35
Pancreas2.8
PancreaticIslet5.85
ParietalLobe3.75
Pituitary6
Placenta3.75
Pons3.4
PrefrontalCortex4.4
Prostate4.15
Salivarygland2.8
SkeletalMuscle7.2
Skin2.75
SmoothMuscle4.05
Spinalcord3.8
SubthalamicNucleus3.25
SuperiorCervicalGanglion4.1
TemporalLobe3.25
Testis3.05
TestisGermCell2.95
TestisIntersitial2.95
TestisLeydigCell3.55
TestisSeminiferousTubule3.05
Thalamus3.6
Thymus2.8
Thyroid4.5
Tongue3.45
Tonsil3.45
Trachea3
TrigeminalGanglion3.6
Uterus2.95
UterusCorpus3.2
WholeBlood3.85
Wholebrain3
colon3.6
pineal_day4.9
pineal_night4.48
retina4.3
small_intestine3.45
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_8794_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.39 ± 1.15
Basal Forebrain2.2 ± 0.52
Basal Part of Pons1.66 ± 0.73
Cerebellar Cortex1.65 ± 0.78
Cerebellar Nuclei2.44 ± 0.61
Claustrum2.81 ± 1
Epithalamus1.55 ± 0.96
Frontal Lobe1.8 ± 0.91
Globus Pallidus2.55 ± 0.55
Hypothalamus1.97 ± 0.78
Insula1.54 ± 0.39
Limbic Lobe1.91 ± 0.84
Mesencephalon2.14 ± 0.86
Myelencephalon2.06 ± 0.83
Occipital Lobe1.98 ± 0.75
Parietal Lobe2.02 ± 0.89
Pontine Tegmentum1.91 ± 0.79
Striatum2.25 ± 0.98
Subthalamus1.89 ± 0.6
Temporal Lobe1.87 ± 0.95
Thalamus1.81 ± 0.68
White Matter1.98 ± 0.18
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Alpk3CBCerebellum9.89
13.68
Alpk3CTXCerebral cortex6.42
5.7
Alpk3HIPHippocampal region3.91
4.4
Alpk3HPFHippocampal formation4.31
4.15
Alpk3HYHypothalamus20.18
16.22
Alpk3LSXLateral septal complex10.08
7.34
Alpk3MBMidbrain14.04
12.47
Alpk3MYMedulla8.61
8.33
Alpk3OLFOlfactory bulb10.47
8.37
Alpk3PPons14.09
14.21
Alpk3PALPallidum8.42
6.96
Alpk3RHPRetrohippocampal region5.09
3.88
Alpk3sAMYStriatum-like amygdalar nuclei3.4
2.79
Alpk3STRStriatum3.15
2.44
Alpk3STRdStriatum dorsal region1.34
1.19
Alpk3STRvStriatum ventral region6.39
4.37
Alpk3THThalamus15.12
13.53
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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