AutismKB 2.0

Annotation Detail for NLGN2


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Basic Information Top
Gene Symbol:NLGN2 ( KIAA1366 )
Gene Full Name: neuroligin 2
Band: 17p13.1
Quick LinksEntrez ID:57555; OMIM: 606479; Uniprot ID:NLGN2_HUMAN; ENSEMBL ID: ENSG00000169992; HGNC ID: 14290
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body7 / 7076198
blastocyst7 / 62319112
fetus26 / 56401246
neonate0 / 310970 
infant1 / 2362042
juvenile0 / 555560 
adult79 / 193912140
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor3 / 9417831
cervical tumor0 / 343660 
chondrosarcoma3 / 8282336
colorectal tumor2 / 11424617
esophageal tumor0 / 172900 
gastrointestinal tumor4 / 11936933
germ cell tumor8 / 26384530
glioma11 / 106883102
head and neck tumor7 / 13630251
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor1 / 9635910
lung tumor3 / 10312729
lymphoma1 / 7175513
non-neoplasia4 / 9725041
normal122 / 336030736
ovarian tumor8 / 76682104
pancreatic tumor4 / 10461638
primitive neuroectodermal tumor of the CNS2 / 12568015
prostate cancer3 / 10268029
retinoblastoma3 / 4635664
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor3 / 12519123
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland2 / 3319760
ascites1 / 4001524
bladder0 / 297570 
blood0 / 1234780 
bone4 / 7165555
bone marrow0 / 488010 
brain34 / 110098930
cervix0 / 481710 
connective tissue5 / 14925533
ear0 / 162120 
embryonic tissue19 / 21572288
esophagus0 / 202090 
eye17 / 21105480
heart1 / 8962611
intestine12 / 23447251
kidney0 / 2117770 
larynx2 / 2414582
liver1 / 2077434
lung12 / 33697435
lymph1 / 4427022
lymph node0 / 916100 
mammary gland5 / 15327132
mouth2 / 6705229
muscle0 / 1077150 
nerve0 / 157680 
ovary11 / 102051107
pancreas12 / 21481255
parathyroid2 / 2053997
pharynx0 / 413280 
pituitary gland1 / 1658560
placenta0 / 2808250 
prostate7 / 18934536
salivary gland0 / 201550 
skin1 / 2105744
spleen1 / 5395218
stomach2 / 9661920
testis3 / 3304429
thymus0 / 811310 
thyroid2 / 4747342
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus10 / 23287842
vascular0 / 517800 
Microarray in BioGPS Top
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_9931_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.98 ± 0.53
Basal Forebrain4.48 ± 0.21
Basal Part of Pons4.52 ± 0.47
Cerebellar Cortex4.18 ± 0.43
Cerebellar Nuclei4.09 ± 0.53
Claustrum4.89 ± 0.78
Epithalamus3.68 ± 0.18
Frontal Lobe4.29 ± 0.51
Globus Pallidus4.36 ± 0.56
Hypothalamus4.27 ± 0.42
Insula4.37 ± 0.4
Limbic Lobe4.78 ± 0.47
Mesencephalon4.41 ± 0.62
Myelencephalon4.43 ± 0.57
Occipital Lobe4.78 ± 0.63
Parietal Lobe4.53 ± 0.52
Pontine Tegmentum4.46 ± 0.5
Striatum4.94 ± 0.42
Subthalamus4.17 ± 0.59
Temporal Lobe4.42 ± 0.48
Thalamus4.39 ± 0.57
White Matter3.92 ± 0.39
Mouse Brain ISH
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018