AutismKB 2.0

Annotation Detail for SEMA6A


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Basic Information Top
Gene Symbol:SEMA6A ( HT018,KIAA1368,SEMA,SEMA6A1,SEMAQ,VIA )
Gene Full Name: sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
Band: 5q23.1
Quick LinksEntrez ID:57556; OMIM: 605885; Uniprot ID:SEM6A_HUMAN; ENSEMBL ID: ENSG00000092421; HGNC ID: 10738
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body6 / 7076184
blastocyst36 / 62319577
fetus59 / 564012104
neonate0 / 310970 
infant0 / 236200 
juvenile2 / 5555635
adult134 / 193912169
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor2 / 12794156
bladder carcinoma0 / 174750 
breast (mammary gland) tumor1 / 9417810
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor1 / 1142468
esophageal tumor0 / 172900 
gastrointestinal tumor1 / 1193698
germ cell tumor53 / 263845200
glioma6 / 10688356
head and neck tumor5 / 13630236
kidney tumor5 / 6895972
leukemia0 / 958420 
liver tumor1 / 9635910
lung tumor3 / 10312729
lymphoma0 / 717550 
non-neoplasia1 / 9725010
normal338 / 3360307100
ovarian tumor2 / 7668226
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS1 / 1256807
prostate cancer1 / 1026809
retinoblastoma1 / 4635621
skin tumor20 / 124949160
soft tissue/muscle tissue tumor2 / 12519115
uterine tumor3 / 9025733
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland5 / 33197150
ascites1 / 4001524
bladder0 / 297570 
blood0 / 1234780 
bone0 / 716550 
bone marrow1 / 4880120
brain90 / 110098981
cervix0 / 481710 
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue66 / 215722305
esophagus0 / 202090 
eye14 / 21105466
heart3 / 8962633
intestine2 / 2344728
kidney6 / 21177728
larynx0 / 241450 
liver2 / 2077439
lung12 / 33697435
lymph0 / 442700 
lymph node3 / 9161032
mammary gland3 / 15327119
mouth5 / 6705274
muscle7 / 10771564
nerve2 / 15768126
ovary8 / 10205178
pancreas7 / 21481232
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta55 / 280825195
prostate2 / 18934510
salivary gland0 / 201550 
skin43 / 210574204
spleen0 / 539520 
stomach0 / 966190 
testis40 / 330442121
thymus1 / 8113112
thyroid0 / 474730 
tonsil0 / 169990 
trachea4 / 5241376
umbilical cord0 / 136800 
uterus8 / 23287834
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 220454_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts24.3
Adipocyte48.2
AdrenalCortex155.2
Adrenalgland111
Amygdala54.45
Appendix51.8
AtrioventricularNode47.5
BDCA4+_DentriticCells20.1
Bonemarrow50.65
BronchialEpithelialCells27.1
CD105+_Endothelial35.3
CD14+_Monocytes17.15
CD19+_BCells(neg._sel.)41.65
CD33+_Myeloid38.15
CD34+38.95
CD4+_Tcells27.7
CD56+_NKCells31.3
CD71+_EarlyErythroid29.8
CD8+_Tcells23.35
CardiacMyocytes54.3
Caudatenucleus62.75
Cerebellum61.9
CerebellumPeduncles120.05
CiliaryGanglion38.3
CingulateCortex70.8
Colorectaladenocarcinoma37.85
DorsalRootGanglion45.3
FetalThyroid49.35
Fetalbrain52.75
Fetalliver45.05
Fetallung41.1
GlobusPallidus46.6
Heart48.9
Hypothalamus62.35
Kidney55.25
Leukemia_chronicMyelogenousK-56246.15
Leukemia_promyelocytic-HL-6040.95
Leukemialymphoblastic(MOLT-4)39.45
Liver77.7
Lung55.3
Lymphnode42.9
Lymphoma_burkitts(Daudi)65.5
Lymphoma_burkitts(Raji)72.85
MedullaOblongata57.05
OccipitalLobe68.45
OlfactoryBulb56.7
Ovary34.9
Pancreas40.45
PancreaticIslet48.2
ParietalLobe96.9
Pituitary60.2
Placenta153.45
Pons62.65
PrefrontalCortex65.5
Prostate56.45
Salivarygland44.3
SkeletalMuscle112.75
Skin40.3
SmoothMuscle28.6
Spinalcord75.55
SubthalamicNucleus75.85
SuperiorCervicalGanglion62.75
TemporalLobe46.65
Testis43
TestisGermCell41.35
TestisIntersitial42
TestisLeydigCell53.75
TestisSeminiferousTubule43.05
Thalamus84
Thymus26.2
Thyroid35.75
Tongue51.4
Tonsil49.75
Trachea46.3
TrigeminalGanglion53.1
Uterus27.45
UterusCorpus50.55
WholeBlood22.75
Wholebrain43.55
colon51.5
pineal_day110.84
pineal_night128.14
retina53.675
small_intestine49.35
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_32_P118942
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.31 ± 0.38
Basal Forebrain7.02 ± 0.33
Basal Part of Pons7.44 ± 0.27
Cerebellar Cortex7.3 ± 0.25
Cerebellar Nuclei7.28 ± 0.23
Claustrum5.79 ± 0.78
Epithalamus6.64 ± 0.56
Frontal Lobe6.76 ± 0.56
Globus Pallidus7.27 ± 0.58
Hypothalamus6.67 ± 0.39
Insula6.63 ± 0.23
Limbic Lobe6.54 ± 0.57
Mesencephalon6.7 ± 0.61
Myelencephalon6.75 ± 0.56
Occipital Lobe6.95 ± 0.48
Parietal Lobe6.51 ± 0.57
Pontine Tegmentum6.67 ± 0.47
Striatum6.77 ± 0.63
Subthalamus6.41 ± 0.86
Temporal Lobe6.59 ± 0.37
Thalamus7.16 ± 0.38
White Matter8.8 ± 0.43
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Sema6aCBCerebellum16.75
17.55
Sema6aCTXCerebral cortex19.26
14.7
Sema6aHIPHippocampal region16.83
17.5
Sema6aHPFHippocampal formation21.26
20.59
Sema6aHYHypothalamus29.89
24.96
Sema6aLSXLateral septal complex25.52
23.67
Sema6aMBMidbrain50.18
47.21
Sema6aMYMedulla25.11
26.95
Sema6aOLFOlfactory bulb67.08
64.38
Sema6aPPons36.07
36.54
Sema6aPALPallidum38.51
38.28
Sema6aRHPRetrohippocampal region30
25.42
Sema6asAMYStriatum-like amygdalar nuclei31.96
26.56
Sema6aSTRStriatum20.52
17.24
Sema6aSTRdStriatum dorsal region19.57
16.6
Sema6aSTRvStriatum ventral region15.99
12.62
Sema6aTHThalamus71.47
67.15
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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