AutismKB 2.0

Annotation Detail for KLHL14


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Basic Information Top
Gene Symbol:KLHL14 ( - )
Gene Full Name: kelch-like 14 (Drosophila)
Band: 18q12.1
Quick LinksEntrez ID:57565; OMIM: NA; Uniprot ID:KLH14_HUMAN; ENSEMBL ID: ENSG00000197705; HGNC ID: 29266
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus5 / 5640128
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult16 / 19391218
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor1 / 1193698
germ cell tumor0 / 2638450 
glioma0 / 1068830 
head and neck tumor0 / 1363020 
kidney tumor1 / 6895914
leukemia1 / 9584210
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal31 / 33603079
ovarian tumor2 / 7668226
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor6 / 9025766
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood1 / 1234788
bone0 / 716550 
bone marrow0 / 488010 
brain12 / 110098910
cervix0 / 481710 
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus0 / 202090 
eye2 / 2110549
heart0 / 896260 
intestine1 / 2344724
kidney2 / 2117779
larynx0 / 241450 
liver0 / 2077430 
lung1 / 3369742
lymph0 / 442700 
lymph node6 / 9161065
mammary gland0 / 1532710 
mouth0 / 670520 
muscle0 / 1077150 
nerve0 / 157680 
ovary2 / 10205119
pancreas0 / 2148120 
parathyroid3 / 20539146
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta11 / 28082539
prostate0 / 1893450 
salivary gland0 / 201550 
skin0 / 2105740 
spleen2 / 5395237
stomach0 / 966190 
testis0 / 3304420 
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus6 / 23287825
vascular0 / 517800 
Microarray in BioGPS Top
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_1767_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala3.13 ± 1.07
Basal Forebrain2.8 ± 0.55
Basal Part of Pons2.39 ± 0.54
Cerebellar Cortex2.46 ± 0.65
Cerebellar Nuclei2.97 ± 0.7
Claustrum3.21 ± 0.59
Epithalamus2.66 ± 1.08
Frontal Lobe3.07 ± 0.84
Globus Pallidus2.57 ± 0.66
Hypothalamus3 ± 0.7
Insula2.78 ± 0.74
Limbic Lobe2.81 ± 0.81
Mesencephalon3.08 ± 0.85
Myelencephalon2.89 ± 0.77
Occipital Lobe2.54 ± 0.83
Parietal Lobe2.93 ± 0.77
Pontine Tegmentum2.85 ± 0.7
Striatum2.3 ± 0.66
Subthalamus2.94 ± 0.82
Temporal Lobe2.97 ± 0.76
Thalamus2.7 ± 0.69
White Matter2.25 ± 0.41
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Klhl14CBCerebellum9.46
10.45
Klhl14CTXCerebral cortex14.92
10.49
Klhl14HIPHippocampal region8.19
7.58
Klhl14HPFHippocampal formation11.3
9.21
Klhl14HYHypothalamus9.21
6.72
Klhl14LSXLateral septal complex2.67
2.28
Klhl14MBMidbrain11.05
9.66
Klhl14MYMedulla20.58
19.33
Klhl14OLFOlfactory bulb35.81
29.5
Klhl14PPons13.49
12.25
Klhl14PALPallidum5.17
4.28
Klhl14RHPRetrohippocampal region17.37
12.09
Klhl14sAMYStriatum-like amygdalar nuclei3.75
2.85
Klhl14STRStriatum5.52
3.84
Klhl14STRdStriatum dorsal region5.36
3.73
Klhl14STRvStriatum ventral region8.76
5.6
Klhl14THThalamus13.22
11.16
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018