AutismKB 2.0

Annotation Detail for PTMA


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Basic Information Top
Gene Symbol:PTMA ( MGC104802,TMSA )
Gene Full Name: prothymosin, alpha
Band: 2q37.1
Quick LinksEntrez ID:5757; OMIM: 188390; Uniprot ID:PTMA_HUMAN; ENSEMBL ID: ENSG00000187514; HGNC ID: 9623
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body73 / 707611031
blastocyst80 / 623191283
fetus127 / 564012225
neonate3 / 3109796
infant10 / 23620423
juvenile39 / 55556701
adult580 / 1939121299
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor7 / 12794547
bladder carcinoma12 / 17475686
breast (mammary gland) tumor51 / 94178541
cervical tumor23 / 34366669
chondrosarcoma8 / 8282396
colorectal tumor65 / 114246568
esophageal tumor4 / 17290231
gastrointestinal tumor113 / 119369946
germ cell tumor140 / 263845530
glioma32 / 106883299
head and neck tumor28 / 136302205
kidney tumor30 / 68959435
leukemia48 / 95842500
liver tumor70 / 96359726
lung tumor72 / 103127698
lymphoma82 / 717551142
non-neoplasia6 / 9725061
normal1179 / 3360307350
ovarian tumor57 / 76682743
pancreatic tumor64 / 104616611
primitive neuroectodermal tumor of the CNS87 / 125680692
prostate cancer60 / 102680584
retinoblastoma105 / 463562265
skin tumor133 / 1249491064
soft tissue/muscle tissue tumor118 / 125191942
uterine tumor52 / 90257576
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue4 / 13106305
adrenal gland11 / 33197331
ascites49 / 400151224
bladder19 / 29757638
blood60 / 123478485
bone36 / 71655502
bone marrow24 / 48801491
brain248 / 1100989225
cervix25 / 48171518
connective tissue6 / 14925540
ear10 / 16212616
embryonic tissue228 / 2157221056
esophagus4 / 20209197
eye169 / 211054800
heart17 / 89626189
intestine99 / 234472422
kidney55 / 211777259
larynx4 / 24145165
liver131 / 207743630
lung124 / 336974367
lymph56 / 442701264
lymph node38 / 91610414
mammary gland63 / 153271411
mouth1 / 6705214
muscle39 / 107715362
nerve10 / 15768634
ovary68 / 102051666
pancreas111 / 214812516
parathyroid5 / 20539243
pharynx75 / 413281814
pituitary gland4 / 16585241
placenta66 / 280825235
prostate69 / 189345364
salivary gland9 / 20155446
skin174 / 210574826
spleen7 / 53952129
stomach68 / 96619703
testis65 / 330442196
thymus13 / 81131160
thyroid20 / 47473421
tonsil41 / 169992411
trachea0 / 524130 
umbilical cord3 / 13680219
uterus152 / 232878652
vascular12 / 51780231
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 211921_x_at
Cell line Expression level Expression bar
721_B_lymphoblasts17478.75
Adipocyte1420.5
AdrenalCortex1934.75
Adrenalgland378.45
Amygdala1151.3
Appendix1684.9
AtrioventricularNode587
BDCA4+_DentriticCells8197.5
Bonemarrow884.15
BronchialEpithelialCells2875.4
CD105+_Endothelial12586.65
CD14+_Monocytes7278.25
CD19+_BCells(neg._sel.)11533.95
CD33+_Myeloid8933.75
CD34+15804.6
CD4+_Tcells6766.3
CD56+_NKCells9521.55
CD71+_EarlyErythroid6787.65
CD8+_Tcells5691.55
CardiacMyocytes2285.95
Caudatenucleus774.15
Cerebellum321.2
CerebellumPeduncles1864.85
CiliaryGanglion823.45
CingulateCortex2336.55
Colorectaladenocarcinoma2780.45
DorsalRootGanglion863.65
FetalThyroid5101.45
Fetalbrain1244.15
Fetalliver527.05
Fetallung1643.6
GlobusPallidus786.95
Heart448.7
Hypothalamus2899.85
Kidney376.2
Leukemia_chronicMyelogenousK-5621428.45
Leukemia_promyelocytic-HL-605635.1
Leukemialymphoblastic(MOLT-4)5478.95
Liver1138.55
Lung4224.6
Lymphnode1241.3
Lymphoma_burkitts(Daudi)3812.15
Lymphoma_burkitts(Raji)5466.25
MedullaOblongata1548.35
OccipitalLobe1495.9
OlfactoryBulb3213.1
Ovary1283.5
Pancreas2276.5
PancreaticIslet3003.3
ParietalLobe2017.9
Pituitary495.95
Placenta3045.6
Pons1042.4
PrefrontalCortex1606.6
Prostate4539.5
Salivarygland512.4
SkeletalMuscle323.75
Skin1401.2
SmoothMuscle1970.3
Spinalcord1272.05
SubthalamicNucleus881.1
SuperiorCervicalGanglion482.3
TemporalLobe1172.65
Testis582.75
TestisGermCell1214.3
TestisIntersitial1094.65
TestisLeydigCell694.75
TestisSeminiferousTubule871
Thalamus673.1
Thymus5144.6
Thyroid4927.2
Tongue3112.2
Tonsil4202.3
Trachea694.7
TrigeminalGanglion1326.75
Uterus3240.1
UterusCorpus2421.2
WholeBlood1126.8
Wholebrain1967.9
colon6721.2
pineal_day3536.96
pineal_night3275.76
retina3275.35
small_intestine5383.15
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P34632
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala11.97 ± 0.27
Basal Forebrain12.44 ± 0.43
Basal Part of Pons12.24 ± 0.39
Cerebellar Cortex11.99 ± 0.18
Cerebellar Nuclei12.62 ± 0.54
Claustrum12.07 ± 0.22
Epithalamus12.68 ± 0.42
Frontal Lobe12.09 ± 0.41
Globus Pallidus13.42 ± 0.22
Hypothalamus11.79 ± 0.58
Insula11.95 ± 0.41
Limbic Lobe12.14 ± 0.33
Mesencephalon12.34 ± 0.46
Myelencephalon12.27 ± 0.49
Occipital Lobe12.47 ± 0.43
Parietal Lobe12.22 ± 0.36
Pontine Tegmentum12.3 ± 0.5
Striatum12.72 ± 0.5
Subthalamus12.51 ± 0.08
Temporal Lobe12.15 ± 0.31
Thalamus12.3 ± 0.39
White Matter14.1 ± 0.29
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
PtmaCBCerebellum100
100
PtmaCTXCerebral cortex100
100
PtmaHIPHippocampal region100
100
PtmaHPFHippocampal formation100
100
PtmaHYHypothalamus100
100
PtmaLSXLateral septal complex100
100
PtmaMBMidbrain100
100
PtmaMYMedulla100
100
PtmaOLFOlfactory bulb100
100
PtmaPPons100
100
PtmaPALPallidum100
100
PtmaRHPRetrohippocampal region100
100
PtmasAMYStriatum-like amygdalar nuclei100
100
PtmaSTRStriatum100
100
PtmaSTRdStriatum dorsal region100
100
PtmaSTRvStriatum ventral region100
100
PtmaTHThalamus100
100
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00001974 29 62 90 EEEEEEEEGDGEEEDGDEDEEAESATGKR Peptide Atlas
PTMA_HUMAN_1 28 1 28 SDAAVDTSSEITTKDLKEKKEVVEEAEN PRIDE
PTMA_HUMAN_1 30 1 30 SDAAVDTSSEITTKDLKEKKEVVEEAENGR PRIDE
PTMA_HUMAN_1 35 1 35 SDAAVDTSSEITTKDLKEKKEVVEEAENGRDAPAN PRIDE
PTMA_HUMAN_2 30 2 31 SDAAVDTSSEITTKDLKEKKEVVEEAENGR PRIDE
PTMA_HUMAN_20 11 20 30 KEVVEEAENGR PRIDE
PTMA_HUMAN_21 10 21 30 EVVEEAENGR PRIDE
PTMA_HUMAN_76 14 76 89 GDEDEEAESATGKR PRIDE
PTMA_HUMAN_80 10 80 89 EEAESATGKR PRIDE
PTMA_HUMAN_90 14 90 103 AAEDDEDDDVDTKK PRIDE
PTMA_HUMAN_90 21 90 110 AAEDDEDDDVDTKKQKTDEDD PRIDE
PTMA_HUMAN_91 20 91 110 AEDDEDDDVDTKKQKTDEDD PRIDE
PTMA_HUMAN_94 17 94 110 DEDDDVDTKKQKTDEDD PRIDE
PTMA_HUMAN_95 16 95 110 EDDDVDTKKQKTDEDD PRIDE
PTMA_HUMAN_98 13 98 110 DVDTKKQKTDEDD PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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