AutismKB 2.0

Annotation Detail for PTPN1


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Basic Information Top
Gene Symbol:PTPN1 ( PTP1B )
Gene Full Name: protein tyrosine phosphatase, non-receptor type 1
Band: 20q13.13
Quick LinksEntrez ID:5770; OMIM: 176885; Uniprot ID:PTN1_HUMAN; ENSEMBL ID: ENSG00000196396; HGNC ID: 9642
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body4 / 7076156
blastocyst5 / 6231980
fetus74 / 564012131
neonate0 / 310970 
infant0 / 236200 
juvenile3 / 5555653
adult161 / 193912183
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor11 / 94178116
cervical tumor2 / 3436658
chondrosarcoma5 / 8282360
colorectal tumor5 / 11424643
esophageal tumor1 / 1729057
gastrointestinal tumor4 / 11936933
germ cell tumor41 / 263845155
glioma13 / 106883121
head and neck tumor50 / 136302366
kidney tumor3 / 6895943
leukemia9 / 9584293
liver tumor10 / 96359103
lung tumor4 / 10312738
lymphoma3 / 7175541
non-neoplasia11 / 97250113
normal271 / 336030780
ovarian tumor2 / 7668226
pancreatic tumor4 / 10461638
primitive neuroectodermal tumor of the CNS1 / 1256807
prostate cancer4 / 10268038
retinoblastoma2 / 4635643
skin tumor7 / 12494956
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor3 / 9025733
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites3 / 4001574
bladder1 / 2975733
blood10 / 12347880
bone4 / 7165555
bone marrow3 / 4880161
brain101 / 110098991
cervix2 / 4817141
connective tissue14 / 14925593
ear0 / 162120 
embryonic tissue11 / 21572250
esophagus1 / 2020949
eye10 / 21105447
heart4 / 8962644
intestine19 / 23447281
kidney32 / 211777151
larynx1 / 2414541
liver16 / 20774377
lung23 / 33697468
lymph3 / 4427067
lymph node8 / 9161087
mammary gland12 / 15327178
mouth35 / 67052521
muscle5 / 10771546
nerve1 / 1576863
ovary2 / 10205119
pancreas7 / 21481232
parathyroid1 / 2053948
pharynx1 / 4132824
pituitary gland0 / 165850 
placenta39 / 280825138
prostate11 / 18934558
salivary gland2 / 2015599
skin11 / 21057452
spleen7 / 53952129
stomach1 / 9661910
testis52 / 330442157
thymus34 / 81131419
thyroid11 / 47473231
tonsil1 / 1699958
trachea15 / 52413286
umbilical cord0 / 136800 
uterus16 / 23287868
vascular4 / 5178077
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 202716_at
Cell line Expression level Expression bar
721_B_lymphoblasts64.7
Adipocyte3.7
AdrenalCortex3.9
Adrenalgland3.15
Amygdala3.95
Appendix3.75
AtrioventricularNode2.85
BDCA4+_DentriticCells116.7
Bonemarrow3.65
BronchialEpithelialCells5.55
CD105+_Endothelial3.8
CD14+_Monocytes13.6
CD19+_BCells(neg._sel.)186.35
CD33+_Myeloid20.95
CD34+13
CD4+_Tcells17.9
CD56+_NKCells58.45
CD71+_EarlyErythroid3.45
CD8+_Tcells36.2
CardiacMyocytes4.6
Caudatenucleus3.35
Cerebellum3.05
CerebellumPeduncles4.2
CiliaryGanglion2.55
CingulateCortex3.75
Colorectaladenocarcinoma4.3
DorsalRootGanglion2.85
FetalThyroid3.65
Fetalbrain3.7
Fetalliver3.25
Fetallung14.95
GlobusPallidus2.65
Heart4.65
Hypothalamus4.1
Kidney3
Leukemia_chronicMyelogenousK-5625.55
Leukemia_promyelocytic-HL-603.3
Leukemialymphoblastic(MOLT-4)5.6
Liver4.85
Lung34.45
Lymphnode10.3
Lymphoma_burkitts(Daudi)4.75
Lymphoma_burkitts(Raji)5.1
MedullaOblongata3.45
OccipitalLobe3.35
OlfactoryBulb3.05
Ovary2.5
Pancreas3
PancreaticIslet6.1
ParietalLobe3.9
Pituitary4.4
Placenta15.25
Pons3.55
PrefrontalCortex4.7
Prostate7.1
Salivarygland3.05
SkeletalMuscle4.15
Skin2.85
SmoothMuscle4.35
Spinalcord5.15
SubthalamicNucleus3.3
SuperiorCervicalGanglion15.3
TemporalLobe3.4
Testis4.6
TestisGermCell3.25
TestisIntersitial3.2
TestisLeydigCell3.7
TestisSeminiferousTubule3.25
Thalamus3.7
Thymus5.3
Thyroid4.7
Tongue3.6
Tonsil10.35
Trachea3.15
TrigeminalGanglion3.6
Uterus3.25
UterusCorpus4.3
WholeBlood6
Wholebrain3.2
colon5.05
pineal_day4.86
pineal_night4.62
retina4.65
small_intestine3.75
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_15135_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.11 ± 0.67
Basal Forebrain4.23 ± 0.41
Basal Part of Pons4.11 ± 0.59
Cerebellar Cortex3.99 ± 0.53
Cerebellar Nuclei3.88 ± 0.41
Claustrum4.2 ± 0.66
Epithalamus3.98 ± 0.22
Frontal Lobe4.15 ± 0.58
Globus Pallidus4.67 ± 0.39
Hypothalamus3.72 ± 0.59
Insula4.05 ± 0.58
Limbic Lobe4.52 ± 0.52
Mesencephalon4.07 ± 0.63
Myelencephalon4.14 ± 0.57
Occipital Lobe4.35 ± 0.47
Parietal Lobe4.28 ± 0.51
Pontine Tegmentum4.34 ± 0.53
Striatum4.46 ± 0.52
Subthalamus3.97 ± 0.37
Temporal Lobe4.12 ± 0.54
Thalamus3.93 ± 0.51
White Matter5.24 ± 0.55
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Ptpn1CBCerebellum1.24
2.38
Ptpn1CTXCerebral cortex1.33
1.37
Ptpn1HIPHippocampal region1.32
1.62
Ptpn1HPFHippocampal formation1.08
1.21
Ptpn1HYHypothalamus0.3
0.19
Ptpn1LSXLateral septal complex0.13
0.17
Ptpn1MBMidbrain0.79
0.78
Ptpn1MYMedulla0.77
0.71
Ptpn1OLFOlfactory bulb3.01
3.93
Ptpn1PPons0.77
0.54
Ptpn1PALPallidum0.88
0.7
Ptpn1RHPRetrohippocampal region0.51
0.43
Ptpn1sAMYStriatum-like amygdalar nuclei1.17
1.06
Ptpn1STRStriatum0.52
0.43
Ptpn1STRdStriatum dorsal region0.5
0.4
Ptpn1STRvStriatum ventral region0.75
0.59
Ptpn1THThalamus1.22
0.88
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00002154 22 293 314 ELSHEDLEPPPEHIPPPPRPPK Peptide Atlas
PTN1_HUMAN_268 11 268 278 FSYLAVIEGAK PRIDE
PTN1_HUMAN_351 21 351 371 GSPLNAAPYGIESMSQDTEVR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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