AutismKB 2.0

Annotation Detail for SEMA4G


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Basic Information Top
Gene Symbol:SEMA4G ( FLJ20590,KIAA1619,MGC102867 )
Gene Full Name: sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G
Band: 10q24.31
Quick LinksEntrez ID:57715; OMIM: NA; Uniprot ID:SEM4G_HUMAN; ENSEMBL ID: ENSG00000095539; HGNC ID: 10735
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body2 / 7076128
blastocyst0 / 623190 
fetus16 / 56401228
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult33 / 193912117
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma1 / 8282312
colorectal tumor10 / 11424687
esophageal tumor0 / 172900 
gastrointestinal tumor2 / 11936916
germ cell tumor7 / 26384526
glioma1 / 1068839
head and neck tumor0 / 1363020 
kidney tumor0 / 689590 
leukemia2 / 9584220
liver tumor7 / 9635972
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal54 / 336030716
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS1 / 1256807
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood1 / 1234788
bone0 / 716550 
bone marrow0 / 488010 
brain14 / 110098912
cervix1 / 4817120
connective tissue2 / 14925513
ear0 / 162120 
embryonic tissue2 / 2157229
esophagus0 / 202090 
eye1 / 2110544
heart0 / 896260 
intestine12 / 23447251
kidney5 / 21177723
larynx0 / 241450 
liver9 / 20774343
lung2 / 3369745
lymph0 / 442700 
lymph node0 / 916100 
mammary gland0 / 1532710 
mouth0 / 670520 
muscle1 / 1077159
nerve0 / 157680 
ovary0 / 1020510 
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta1 / 2808253
prostate4 / 18934521
salivary gland0 / 201550 
skin0 / 2105740 
spleen2 / 5395237
stomach6 / 9661962
testis5 / 33044215
thymus0 / 811310 
thyroid1 / 4747321
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus0 / 2328780 
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 219194_at
Cell line Expression level Expression bar
721_B_lymphoblasts5.45
Adipocyte4.65
AdrenalCortex4.75
Adrenalgland7.55
Amygdala4.55
Appendix6.3
AtrioventricularNode4.5
BDCA4+_DentriticCells4.45
Bonemarrow4.45
BronchialEpithelialCells4.2
CD105+_Endothelial4.2
CD14+_Monocytes4.1
CD19+_BCells(neg._sel.)4.5
CD33+_Myeloid5.25
CD34+5.35
CD4+_Tcells5.55
CD56+_NKCells4.95
CD71+_EarlyErythroid4
CD8+_Tcells4.1
CardiacMyocytes4.85
Caudatenucleus3.95
Cerebellum8.95
CerebellumPeduncles7.95
CiliaryGanglion3.15
CingulateCortex4.55
Colorectaladenocarcinoma3.9
DorsalRootGanglion3.5
FetalThyroid4.25
Fetalbrain15.4
Fetalliver14.45
Fetallung5.2
GlobusPallidus3.3
Heart5.6
Hypothalamus5.25
Kidney5.05
Leukemia_chronicMyelogenousK-5623.95
Leukemia_promyelocytic-HL-603.85
Leukemialymphoblastic(MOLT-4)3.7
Liver5.9
Lung4.7
Lymphnode3.9
Lymphoma_burkitts(Daudi)5.65
Lymphoma_burkitts(Raji)6.2
MedullaOblongata4.4
OccipitalLobe4.05
OlfactoryBulb6.25
Ovary3.35
Pancreas3.75
PancreaticIslet5.75
ParietalLobe5.45
Pituitary6.4
Placenta4.25
Pons5.2
PrefrontalCortex5.65
Prostate5.4
Salivarygland3.55
SkeletalMuscle5.75
Skin4.4
SmoothMuscle4.8
Spinalcord5.15
SubthalamicNucleus4.05
SuperiorCervicalGanglion11.05
TemporalLobe4.8
Testis3.75
TestisGermCell3.6
TestisIntersitial3.7
TestisLeydigCell4.35
TestisSeminiferousTubule3.85
Thalamus6.65
Thymus3.35
Thyroid5.35
Tongue4.45
Tonsil4.6
Trachea3.7
TrigeminalGanglion5.6
Uterus3.5
UterusCorpus9.7
WholeBlood4.4
Wholebrain3.7
colon4.5
pineal_day5.62
pineal_night5.4
retina5.2
small_intestine4.45
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_9844_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala3.52 ± 1.02
Basal Forebrain3.65 ± 0.57
Basal Part of Pons3.27 ± 0.59
Cerebellar Cortex4.06 ± 0.27
Cerebellar Nuclei3.35 ± 0.74
Claustrum3.65 ± 0.78
Epithalamus3.07 ± 0.49
Frontal Lobe3.2 ± 0.78
Globus Pallidus3.39 ± 0.43
Hypothalamus3.52 ± 0.5
Insula3.36 ± 1.16
Limbic Lobe3.26 ± 0.68
Mesencephalon3.51 ± 0.75
Myelencephalon3.46 ± 0.72
Occipital Lobe3.53 ± 0.65
Parietal Lobe3.5 ± 0.84
Pontine Tegmentum3.44 ± 0.69
Striatum3.07 ± 0.77
Subthalamus3.13 ± 0.24
Temporal Lobe3.36 ± 0.72
Thalamus4.2 ± 0.55
White Matter3.27 ± 0.34
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Sema4gCBCerebellum63.47
94.17
Sema4gCTXCerebral cortex35.23
25.88
Sema4gHIPHippocampal region25.48
28.16
Sema4gHPFHippocampal formation31.76
29.5
Sema4gHYHypothalamus100
87.43
Sema4gLSXLateral septal complex61.96
41.06
Sema4gMBMidbrain81.14
67.53
Sema4gMYMedulla62.96
58.78
Sema4gOLFOlfactory bulb51.08
44.95
Sema4gPPons62.4
53.13
Sema4gPALPallidum74.77
62.06
Sema4gRHPRetrohippocampal region42.66
31.87
Sema4gsAMYStriatum-like amygdalar nuclei73.56
52.07
Sema4gSTRStriatum24.9
17.51
Sema4gSTRdStriatum dorsal region12.36
9.13
Sema4gSTRvStriatum ventral region25.32
16.24
Sema4gTHThalamus100
100
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00042448 11 757 767 SCLQIIPGEGA Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018