AutismKB 2.0

Annotation Detail for PPP4R4


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Basic Information Top
Gene Symbol:PPP4R4 ( KIAA1622,PP4R4 )
Gene Full Name: protein phosphatase 4, regulatory subunit 4
Band: 14q32.2
Quick LinksEntrez ID:57718; OMIM: NA; Uniprot ID:PP4R4_HUMAN; ENSEMBL ID: ENSG00000119698; HGNC ID: 23788
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst1 / 6231916
fetus4 / 5640127
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult6 / 19391213
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor3 / 9417831
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor0 / 2638450 
glioma0 / 1068830 
head and neck tumor0 / 1363020 
kidney tumor2 / 6895929
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal21 / 33603076
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone0 / 716550 
bone marrow0 / 488010 
brain15 / 110098913
cervix0 / 481710 
connective tissue1 / 1492556
ear0 / 162120 
embryonic tissue1 / 2157224
esophagus0 / 202090 
eye3 / 21105414
heart0 / 896260 
intestine0 / 2344720 
kidney2 / 2117779
larynx0 / 241450 
liver1 / 2077434
lung0 / 3369740 
lymph0 / 442700 
lymph node0 / 916100 
mammary gland3 / 15327119
mouth0 / 670520 
muscle1 / 1077159
nerve0 / 157680 
ovary0 / 1020510 
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate1 / 1893455
salivary gland0 / 201550 
skin0 / 2105740 
spleen0 / 539520 
stomach0 / 966190 
testis2 / 3304426
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord0 / 136800 
uterus2 / 2328788
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 220673_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts5.95
Adipocyte5.05
AdrenalCortex6.15
Adrenalgland4.7
Amygdala5.2
Appendix5.7
AtrioventricularNode4.6
BDCA4+_DentriticCells5.25
Bonemarrow5.3
BronchialEpithelialCells5.05
CD105+_Endothelial5.15
CD14+_Monocytes5.3
CD19+_BCells(neg._sel.)5.15
CD33+_Myeloid6.35
CD34+6.1
CD4+_Tcells5.2
CD56+_NKCells5.65
CD71+_EarlyErythroid5.4
CD8+_Tcells4.5
CardiacMyocytes7.15
Caudatenucleus4.6
Cerebellum4.15
CerebellumPeduncles7.15
CiliaryGanglion4.15
CingulateCortex5.45
Colorectaladenocarcinoma5.15
DorsalRootGanglion4.55
FetalThyroid5
Fetalbrain4.85
Fetalliver4.5
Fetallung3.85
GlobusPallidus3.9
Heart7.6
Hypothalamus5.45
Kidney4.45
Leukemia_chronicMyelogenousK-5624.6
Leukemia_promyelocytic-HL-604.55
Leukemialymphoblastic(MOLT-4)4
Liver7.25
Lung5.4
Lymphnode4.05
Lymphoma_burkitts(Daudi)6.7
Lymphoma_burkitts(Raji)7.5
MedullaOblongata4.6
OccipitalLobe4.5
OlfactoryBulb3.95
Ovary3.6
Pancreas4.25
PancreaticIslet5.4
ParietalLobe5.7
Pituitary5.95
Placenta5
Pons5.05
PrefrontalCortex6.1
Prostate5.8
Salivarygland4.3
SkeletalMuscle7.35
Skin4.3
SmoothMuscle5.7
Spinalcord5.3
SubthalamicNucleus4.85
SuperiorCervicalGanglion6.4
TemporalLobe4.75
Testis4.4
TestisGermCell4.15
TestisIntersitial5.15
TestisLeydigCell5.25
TestisSeminiferousTubule4.35
Thalamus5.25
Thymus3.9
Thyroid6.05
Tongue5.6
Tonsil5
Trachea4.15
TrigeminalGanglion5.65
Uterus4.1
UterusCorpus4.95
WholeBlood5.55
Wholebrain4.1
colon5.15
pineal_day6.16
pineal_night6.04
retina6.05
small_intestine4.75
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_9333_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.39 ± 0.43
Basal Forebrain5.98 ± 0.3
Basal Part of Pons5.82 ± 0.47
Cerebellar Cortex5.78 ± 0.3
Cerebellar Nuclei5.18 ± 0.38
Claustrum5.42 ± 0.45
Epithalamus5.44 ± 0.42
Frontal Lobe5.88 ± 0.56
Globus Pallidus5.04 ± 0.38
Hypothalamus5.61 ± 0.68
Insula6.42 ± 0.51
Limbic Lobe6.46 ± 0.57
Mesencephalon5.64 ± 0.54
Myelencephalon5.84 ± 0.54
Occipital Lobe5.48 ± 0.59
Parietal Lobe5.79 ± 0.58
Pontine Tegmentum5.93 ± 0.69
Striatum6.48 ± 0.39
Subthalamus5.23 ± 0.3
Temporal Lobe6.13 ± 0.54
Thalamus5.89 ± 0.47
White Matter3.62 ± 0.24
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
8430415E04RikCBCerebellum21.7
99.29
8430415E04RikCTXCerebral cortex37.99
29.03
8430415E04RikHIPHippocampal region60.44
95.24
8430415E04RikHPFHippocampal formation52.93
74.13
8430415E04RikHYHypothalamus13.12
10.86
8430415E04RikLSXLateral septal complex51.87
43.2
8430415E04RikMBMidbrain20.73
18.97
8430415E04RikMYMedulla27.03
35.22
8430415E04RikOLFOlfactory bulb51.71
48.51
8430415E04RikPPons20.74
23.68
8430415E04RikPALPallidum23.78
21.98
8430415E04RikRHPRetrohippocampal region42.04
37.71
8430415E04RiksAMYStriatum-like amygdalar nuclei27.02
19.46
8430415E04RikSTRStriatum92.73
78.54
8430415E04RikSTRdStriatum dorsal region100
94.81
8430415E04RikSTRvStriatum ventral region68.15
50.85
8430415E04RikTHThalamus92.59
92.45
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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