AutismKB 2.0

Annotation Detail for METTL14


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Basic Information Top
Gene Symbol:METTL14 ( KIAA1627 )
Gene Full Name: methyltransferase like 14
Band: 4q26
Quick LinksEntrez ID:57721; OMIM: NA; Uniprot ID:MTL14_HUMAN; ENSEMBL ID: ENSG00000145388; HGNC ID: 29330
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst3 / 6231948
fetus6 / 56401210
neonate2 / 3109764
infant0 / 236200 
juvenile2 / 5555635
adult45 / 193912123
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor3 / 9417831
cervical tumor0 / 343660 
chondrosarcoma2 / 8282324
colorectal tumor1 / 1142468
esophageal tumor0 / 172900 
gastrointestinal tumor2 / 11936916
germ cell tumor12 / 26384545
glioma0 / 1068830 
head and neck tumor0 / 1363020 
kidney tumor2 / 6895929
leukemia2 / 9584220
liver tumor0 / 963590 
lung tumor1 / 1031279
lymphoma1 / 7175513
non-neoplasia1 / 9725010
normal88 / 336030726
ovarian tumor3 / 7668239
pancreatic tumor2 / 10461619
primitive neuroectodermal tumor of the CNS4 / 12568031
prostate cancer0 / 1026800 
retinoblastoma3 / 4635664
skin tumor1 / 1249498
soft tissue/muscle tissue tumor12 / 12519195
uterine tumor7 / 9025777
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland1 / 3319730
ascites1 / 4001524
bladder0 / 297570 
blood7 / 12347856
bone2 / 7165527
bone marrow1 / 4880120
brain14 / 110098912
cervix0 / 481710 
connective tissue6 / 14925540
ear0 / 162120 
embryonic tissue6 / 21572227
esophagus0 / 202090 
eye5 / 21105423
heart1 / 8962611
intestine5 / 23447221
kidney14 / 21177766
larynx0 / 241450 
liver3 / 20774314
lung7 / 33697420
lymph1 / 4427022
lymph node3 / 9161032
mammary gland5 / 15327132
mouth0 / 670520 
muscle7 / 10771564
nerve1 / 1576863
ovary2 / 10205119
pancreas11 / 21481251
parathyroid0 / 205390 
pharynx4 / 4132896
pituitary gland0 / 165850 
placenta6 / 28082521
prostate4 / 18934521
salivary gland0 / 201550 
skin2 / 2105749
spleen3 / 5395255
stomach1 / 9661910
testis15 / 33044245
thymus3 / 8113136
thyroid0 / 474730 
tonsil1 / 1699958
trachea1 / 5241319
umbilical cord1 / 1368073
uterus13 / 23287855
vascular2 / 5178038
Microarray in BioGPS Top
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_11647_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.18 ± 0.37
Basal Forebrain5.11 ± 0.22
Basal Part of Pons4.69 ± 0.34
Cerebellar Cortex5.11 ± 0.41
Cerebellar Nuclei4.99 ± 0.57
Claustrum5.19 ± 0.53
Epithalamus5.29 ± 0.61
Frontal Lobe4.75 ± 0.4
Globus Pallidus5.26 ± 0.4
Hypothalamus4.8 ± 0.43
Insula4.77 ± 0.41
Limbic Lobe4.95 ± 0.49
Mesencephalon5 ± 0.52
Myelencephalon5.02 ± 0.55
Occipital Lobe5.48 ± 0.45
Parietal Lobe5 ± 0.48
Pontine Tegmentum5.13 ± 0.52
Striatum5.31 ± 0.48
Subthalamus4.28 ± 0.68
Temporal Lobe4.86 ± 0.5
Thalamus5.02 ± 0.39
White Matter5.44 ± 0.46
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
G430022H21RikCBCerebellum27.75
30.4
G430022H21RikCTXCerebral cortex59.45
45.71
G430022H21RikHIPHippocampal region43.73
46.66
G430022H21RikHPFHippocampal formation46.63
44.03
G430022H21RikHYHypothalamus54.98
49.25
G430022H21RikLSXLateral septal complex23.88
15.97
G430022H21RikMBMidbrain32.34
30.14
G430022H21RikMYMedulla55.92
65.77
G430022H21RikOLFOlfactory bulb82.01
69.87
G430022H21RikPPons45.47
55.66
G430022H21RikPALPallidum36.58
35.43
G430022H21RikRHPRetrohippocampal region55.42
42.07
G430022H21RiksAMYStriatum-like amygdalar nuclei23.47
18.5
G430022H21RikSTRStriatum35.82
29.21
G430022H21RikSTRdStriatum dorsal region28.23
21.33
G430022H21RikSTRvStriatum ventral region75.04
64.87
G430022H21RikTHThalamus36.87
30.7
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018