AutismKB 2.0

Annotation Detail for ZFYVE28


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Basic Information Top
Gene Symbol:ZFYVE28 ( LYST2,MGC43699,MGC61592 )
Gene Full Name: zinc finger, FYVE domain containing 28
Band: 4p16.3
Quick LinksEntrez ID:57732; OMIM: NA; Uniprot ID:LST2_HUMAN; ENSEMBL ID: ENSG00000159733; HGNC ID: 29334
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus6 / 56401210
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult24 / 193912112
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma1 / 8282312
colorectal tumor1 / 1142468
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor0 / 2638450 
glioma1 / 1068839
head and neck tumor1 / 1363027
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia1 / 9725010
normal49 / 336030714
ovarian tumor0 / 766820 
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor3 / 12494924
soft tissue/muscle tissue tumor2 / 12519115
uterine tumor4 / 9025744
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone0 / 716550 
bone marrow0 / 488010 
brain31 / 110098928
cervix0 / 481710 
connective tissue2 / 14925513
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus0 / 202090 
eye3 / 21105414
heart0 / 896260 
intestine2 / 2344728
kidney1 / 2117774
larynx0 / 241450 
liver0 / 2077430 
lung3 / 3369748
lymph0 / 442700 
lymph node0 / 916100 
mammary gland0 / 1532710 
mouth0 / 670520 
muscle1 / 1077159
nerve0 / 157680 
ovary2 / 10205119
pancreas8 / 21481237
parathyroid0 / 205390 
pharynx1 / 4132824
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate0 / 1893450 
salivary gland0 / 201550 
skin3 / 21057414
spleen1 / 5395218
stomach0 / 966190 
testis5 / 33044215
thymus3 / 8113136
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus7 / 23287830
vascular0 / 517800 
Microarray in BioGPS Top
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_32_P104746
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala7.49 ± 0.41
Basal Forebrain7.33 ± 0.32
Basal Part of Pons8.11 ± 0.26
Cerebellar Cortex8.3 ± 0.18
Cerebellar Nuclei7.92 ± 0.43
Claustrum7.27 ± 0.44
Epithalamus6.86 ± 0.45
Frontal Lobe7.86 ± 0.4
Globus Pallidus6.54 ± 0.31
Hypothalamus7.35 ± 0.38
Insula7.91 ± 0.24
Limbic Lobe7.82 ± 0.48
Mesencephalon7.55 ± 0.52
Myelencephalon7.68 ± 0.48
Occipital Lobe8.1 ± 0.39
Parietal Lobe7.81 ± 0.49
Pontine Tegmentum7.73 ± 0.55
Striatum7.38 ± 0.39
Subthalamus8.01 ± 0.27
Temporal Lobe7.88 ± 0.36
Thalamus7.91 ± 0.42
White Matter6.31 ± 0.35
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Zfyve28CBCerebellum47.67
58.06
Zfyve28CTXCerebral cortex100
75.2
Zfyve28HIPHippocampal region43.31
57.1
Zfyve28HPFHippocampal formation55.72
53.67
Zfyve28HYHypothalamus12.76
8.7
Zfyve28LSXLateral septal complex11.21
6.41
Zfyve28MBMidbrain23.54
19.49
Zfyve28MYMedulla29.27
27.16
Zfyve28OLFOlfactory bulb97.03
83.63
Zfyve28PPons29.11
27.63
Zfyve28PALPallidum18.99
13.93
Zfyve28RHPRetrohippocampal region70.78
48.96
Zfyve28sAMYStriatum-like amygdalar nuclei27.45
15.19
Zfyve28STRStriatum100
77.6
Zfyve28STRdStriatum dorsal region100
86.4
Zfyve28STRvStriatum ventral region100
77.4
Zfyve28THThalamus65.28
49.97
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
LST2_HUMAN_15 8 15 22 SDPQLLAR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018