AutismKB 2.0

Annotation Detail for SCUBE2


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Basic Information Top
Gene Symbol:SCUBE2 ( CEGB1,CEGF1,CEGP1,FLJ16792,FLJ35234,MGC133057 )
Gene Full Name: signal peptide, CUB domain, EGF-like 2
Band: 11p15.4
Quick LinksEntrez ID:57758; OMIM: 611747; Uniprot ID:SCUB2_HUMAN; ENSEMBL ID: ENSG00000175356; HGNC ID: 30425
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus22 / 56401239
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult89 / 193912145
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma2 / 17475114
breast (mammary gland) tumor31 / 94178329
cervical tumor0 / 343660 
chondrosarcoma1 / 8282312
colorectal tumor1 / 1142468
esophageal tumor0 / 172900 
gastrointestinal tumor1 / 1193698
germ cell tumor8 / 26384530
glioma6 / 10688356
head and neck tumor0 / 1363020 
kidney tumor1 / 6895914
leukemia1 / 9584210
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal73 / 336030721
ovarian tumor0 / 766820 
pancreatic tumor3 / 10461628
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer1 / 1026809
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone0 / 716550 
bone marrow1 / 4880120
brain13 / 110098911
cervix0 / 481710 
connective tissue1 / 1492556
ear0 / 162120 
embryonic tissue1 / 2157224
esophagus0 / 202090 
eye5 / 21105423
heart6 / 8962666
intestine2 / 2344728
kidney1 / 2117774
larynx0 / 241450 
liver0 / 2077430 
lung4 / 33697411
lymph0 / 442700 
lymph node0 / 916100 
mammary gland39 / 153271254
mouth0 / 670520 
muscle0 / 1077150 
nerve0 / 157680 
ovary2 / 10205119
pancreas7 / 21481232
parathyroid0 / 205390 
pharynx1 / 4132824
pituitary gland0 / 165850 
placenta6 / 28082521
prostate24 / 189345126
salivary gland0 / 201550 
skin0 / 2105740 
spleen0 / 539520 
stomach2 / 9661920
testis3 / 3304429
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus0 / 2328780 
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 219197_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts4.65
Adipocyte4.05
AdrenalCortex4.4
Adrenalgland3.6
Amygdala4.15
Appendix4.15
AtrioventricularNode3.25
BDCA4+_DentriticCells4.4
Bonemarrow4.1
BronchialEpithelialCells4.05
CD105+_Endothelial4
CD14+_Monocytes4.2
CD19+_BCells(neg._sel.)4.15
CD33+_Myeloid4.8
CD34+5.1
CD4+_Tcells4.4
CD56+_NKCells4.8
CD71+_EarlyErythroid3.8
CD8+_Tcells3.75
CardiacMyocytes5.3
Caudatenucleus3.7
Cerebellum3.45
CerebellumPeduncles4.65
CiliaryGanglion2.95
CingulateCortex4.2
Colorectaladenocarcinoma4
DorsalRootGanglion3.2
FetalThyroid4
Fetalbrain4.1
Fetalliver3.5
Fetallung3.7
GlobusPallidus3
Heart5.15
Hypothalamus4.45
Kidney3.35
Leukemia_chronicMyelogenousK-5623.75
Leukemia_promyelocytic-HL-603.55
Leukemialymphoblastic(MOLT-4)3.35
Liver5.4
Lung4.65
Lymphnode3.8
Lymphoma_burkitts(Daudi)5.2
Lymphoma_burkitts(Raji)5.75
MedullaOblongata3.75
OccipitalLobe3.7
OlfactoryBulb3.3
Ovary2.8
Pancreas3.6
PancreaticIslet4.4
ParietalLobe4.35
Pituitary5.4
Placenta9.55
Pons3.9
PrefrontalCortex4.95
Prostate25.85
Salivarygland3.7
SkeletalMuscle6.95
Skin3.35
SmoothMuscle4.65
Spinalcord4.4
SubthalamicNucleus3.75
SuperiorCervicalGanglion4.85
TemporalLobe3.75
Testis4.1
TestisGermCell3.45
TestisIntersitial3.5
TestisLeydigCell4.95
TestisSeminiferousTubule3.5
Thalamus4.15
Thymus3.2
Thyroid5.05
Tongue5.5
Tonsil4.35
Trachea3.85
TrigeminalGanglion4.15
Uterus4.1
UterusCorpus3.7
WholeBlood4.5
Wholebrain3.45
colon4.15
pineal_day5.46
pineal_night5
retina6.825
small_intestine19.95
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_7156_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.98 ± 0.7
Basal Forebrain2.7 ± 0.6
Basal Part of Pons2.14 ± 0.54
Cerebellar Cortex3.25 ± 0.29
Cerebellar Nuclei2.51 ± 0.7
Claustrum2.95 ± 0.87
Epithalamus2.65 ± 0.99
Frontal Lobe2.55 ± 0.7
Globus Pallidus2.8 ± 0.72
Hypothalamus3.01 ± 0.27
Insula2.43 ± 0.82
Limbic Lobe2.62 ± 0.61
Mesencephalon2.81 ± 0.65
Myelencephalon2.65 ± 0.62
Occipital Lobe2.57 ± 0.65
Parietal Lobe2.44 ± 0.76
Pontine Tegmentum2.82 ± 0.69
Striatum2.47 ± 0.69
Subthalamus3.3 ± 0.61
Temporal Lobe2.62 ± 0.71
Thalamus2.87 ± 0.62
White Matter3.09 ± 0.13
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Scube2CBCerebellum1.66
2.59
Scube2CTXCerebral cortex1.71
1.64
Scube2HIPHippocampal region1.16
1.33
Scube2HPFHippocampal formation0.95
1.02
Scube2HYHypothalamus0.32
0.3
Scube2LSXLateral septal complex0.34
0.6
Scube2MBMidbrain0.52
0.66
Scube2MYMedulla1.19
1.86
Scube2OLFOlfactory bulb6.25
6.35
Scube2PPons0.36
0.44
Scube2PALPallidum0.85
0.65
Scube2RHPRetrohippocampal region0.52
0.55
Scube2sAMYStriatum-like amygdalar nuclei1.37
1.11
Scube2STRStriatum0.75
0.7
Scube2STRdStriatum dorsal region0.76
0.77
Scube2STRvStriatum ventral region0.64
0.47
Scube2THThalamus8.55
6.45
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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