AutismKB 2.0

Annotation Detail for PTPN7


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Basic Information Top
Gene Symbol:PTPN7 ( BPTP-4,HEPTP,LC-PTP,LPTP,PTPNI )
Gene Full Name: protein tyrosine phosphatase, non-receptor type 7
Band: 1q32.1
Quick LinksEntrez ID:5778; OMIM: 176889; Uniprot ID:PTN7_HUMAN; ENSEMBL ID: ENSG00000143851; HGNC ID: 9659
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus4 / 5640127
neonate4 / 31097128
infant0 / 236200 
juvenile8 / 55556143
adult39 / 193912120
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor2 / 9417821
cervical tumor0 / 343660 
chondrosarcoma1 / 8282312
colorectal tumor3 / 11424626
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor7 / 26384526
glioma0 / 1068830 
head and neck tumor0 / 1363020 
kidney tumor1 / 6895914
leukemia36 / 95842375
liver tumor3 / 9635931
lung tumor0 / 1031270 
lymphoma9 / 71755125
non-neoplasia3 / 9725030
normal110 / 336030732
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer1 / 1026809
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor3 / 9025733
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland7 / 33197210
ascites0 / 400150 
bladder0 / 297570 
blood44 / 123478356
bone0 / 716550 
bone marrow4 / 4880181
brain9 / 11009898
cervix0 / 481710 
connective tissue4 / 14925526
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus0 / 202090 
eye0 / 2110540 
heart0 / 896260 
intestine7 / 23447229
kidney5 / 21177723
larynx0 / 241450 
liver5 / 20774324
lung2 / 3369745
lymph4 / 4427090
lymph node13 / 91610141
mammary gland2 / 15327113
mouth0 / 670520 
muscle2 / 10771518
nerve0 / 157680 
ovary0 / 1020510 
pancreas2 / 2148129
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate3 / 18934515
salivary gland0 / 201550 
skin0 / 2105740 
spleen23 / 53952426
stomach1 / 9661910
testis24 / 33044272
thymus60 / 81131739
thyroid0 / 474730 
tonsil3 / 16999176
trachea1 / 5241319
umbilical cord0 / 136800 
uterus4 / 23287817
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 204852_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts375.75
Adipocyte18.05
AdrenalCortex29.95
Adrenalgland27.1
Amygdala17.15
Appendix29.6
AtrioventricularNode21.9
BDCA4+_DentriticCells25.3
Bonemarrow113.95
BronchialEpithelialCells9.9
CD105+_Endothelial44.85
CD14+_Monocytes18.25
CD19+_BCells(neg._sel.)41.95
CD33+_Myeloid23
CD34+191.3
CD4+_Tcells132.45
CD56+_NKCells163.45
CD71+_EarlyErythroid14.7
CD8+_Tcells147.55
CardiacMyocytes20
Caudatenucleus25.25
Cerebellum13.55
CerebellumPeduncles22.15
CiliaryGanglion12.45
CingulateCortex17.2
Colorectaladenocarcinoma11.85
DorsalRootGanglion14.4
FetalThyroid16.2
Fetalbrain16.5
Fetalliver14.4
Fetallung13.45
GlobusPallidus12.15
Heart22.25
Hypothalamus14.6
Kidney25.4
Leukemia_chronicMyelogenousK-56215.05
Leukemia_promyelocytic-HL-6016.9
Leukemialymphoblastic(MOLT-4)30.85
Liver21.8
Lung21.65
Lymphnode113.9
Lymphoma_burkitts(Daudi)152.25
Lymphoma_burkitts(Raji)36.4
MedullaOblongata23.8
OccipitalLobe14.9
OlfactoryBulb13.2
Ovary21
Pancreas13.5
PancreaticIslet15.7
ParietalLobe23.1
Pituitary19.6
Placenta11.3
Pons25.25
PrefrontalCortex12.4
Prostate17.9
Salivarygland19.7
SkeletalMuscle30.2
Skin13.7
SmoothMuscle14.55
Spinalcord22
SubthalamicNucleus14.05
SuperiorCervicalGanglion25.05
TemporalLobe18.05
Testis23.8
TestisGermCell37.15
TestisIntersitial23.05
TestisLeydigCell28.1
TestisSeminiferousTubule23.4
Thalamus15.3
Thymus382.85
Thyroid20.6
Tongue16.5
Tonsil89.35
Trachea16.75
TrigeminalGanglion27.85
Uterus8.8
UterusCorpus23.2
WholeBlood58.6
Wholebrain14.15
colon10.4
pineal_day10.86
pineal_night10.94
retina18.1
small_intestine14.5
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P276808
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.54 ± 1.11
Basal Forebrain2.33 ± 0.6
Basal Part of Pons1.67 ± 0.49
Cerebellar Cortex1.65 ± 0.77
Cerebellar Nuclei2.29 ± 0.68
Claustrum2.91 ± 1.05
Epithalamus1.63 ± 0.84
Frontal Lobe1.81 ± 0.73
Globus Pallidus2.38 ± 0.59
Hypothalamus2.06 ± 0.73
Insula1.61 ± 0.69
Limbic Lobe1.98 ± 0.73
Mesencephalon2.36 ± 1.06
Myelencephalon2.13 ± 0.8
Occipital Lobe2.3 ± 0.96
Parietal Lobe2.25 ± 1.01
Pontine Tegmentum2.15 ± 0.84
Striatum3.8 ± 0.72
Subthalamus2.25 ± 0.77
Temporal Lobe1.93 ± 0.87
Thalamus2.03 ± 0.81
White Matter2.09 ± 0.19
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Ptpn7CBCerebellum0.96
1.08
Ptpn7CTXCerebral cortex0.33
0.63
Ptpn7HIPHippocampal region0.27
0.33
Ptpn7HPFHippocampal formation0.28
0.5
Ptpn7HYHypothalamus0.57
0.72
Ptpn7LSXLateral septal complex0
0
Ptpn7MBMidbrain0.21
0.31
Ptpn7MYMedulla3.1
4.46
Ptpn7OLFOlfactory bulb0.83
0.68
Ptpn7PPons0.48
0.67
Ptpn7PALPallidum3.16
5.35
Ptpn7RHPRetrohippocampal region0.3
0.77
Ptpn7sAMYStriatum-like amygdalar nuclei0.42
0.38
Ptpn7STRStriatum0.69
0.78
Ptpn7STRdStriatum dorsal region0.92
1.1
Ptpn7STRvStriatum ventral region0.27
0.16
Ptpn7THThalamus2.43
3.81
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00010883 28 375 402 LVAEVEESPETAAHPGPIVVHCSAGIGR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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