AutismKB 2.0

Annotation Detail for PTPN9


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Basic Information Top
Gene Symbol:PTPN9 ( MEG2,PTPMEG2 )
Gene Full Name: protein tyrosine phosphatase, non-receptor type 9
Band: 15q24.2
Quick LinksEntrez ID:5780; OMIM: 600768; Uniprot ID:PTN9_HUMAN; ENSEMBL ID: ENSG00000169410; HGNC ID: 9661
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body3 / 7076142
blastocyst2 / 6231932
fetus38 / 56401267
neonate2 / 3109764
infant0 / 236200 
juvenile1 / 5555617
adult88 / 193912145
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor2 / 12794156
bladder carcinoma1 / 1747557
breast (mammary gland) tumor2 / 9417821
cervical tumor0 / 343660 
chondrosarcoma3 / 8282336
colorectal tumor11 / 11424696
esophageal tumor1 / 1729057
gastrointestinal tumor3 / 11936925
germ cell tumor8 / 26384530
glioma10 / 10688393
head and neck tumor5 / 13630236
kidney tumor1 / 6895914
leukemia2 / 9584220
liver tumor1 / 9635910
lung tumor4 / 10312738
lymphoma0 / 717550 
non-neoplasia2 / 9725020
normal115 / 336030734
ovarian tumor4 / 7668252
pancreatic tumor2 / 10461619
primitive neuroectodermal tumor of the CNS3 / 12568023
prostate cancer5 / 10268048
retinoblastoma0 / 463560 
skin tumor2 / 12494916
soft tissue/muscle tissue tumor8 / 12519163
uterine tumor2 / 9025722
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland2 / 3319760
ascites0 / 400150 
bladder0 / 297570 
blood4 / 12347832
bone3 / 7165541
bone marrow0 / 488010 
brain30 / 110098927
cervix0 / 481710 
connective tissue6 / 14925540
ear0 / 162120 
embryonic tissue7 / 21572232
esophagus1 / 2020949
eye2 / 2110549
heart4 / 8962644
intestine15 / 23447263
kidney8 / 21177737
larynx2 / 2414582
liver1 / 2077434
lung31 / 33697491
lymph0 / 442700 
lymph node2 / 9161021
mammary gland2 / 15327113
mouth1 / 6705214
muscle3 / 10771527
nerve0 / 157680 
ovary5 / 10205148
pancreas5 / 21481223
parathyroid1 / 2053948
pharynx1 / 4132824
pituitary gland2 / 16585120
placenta13 / 28082546
prostate10 / 18934552
salivary gland6 / 20155297
skin3 / 21057414
spleen1 / 5395218
stomach1 / 9661910
testis5 / 33044215
thymus6 / 8113173
thyroid3 / 4747363
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord1 / 1368073
uterus11 / 23287847
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 202958_at
Cell line Expression level Expression bar
721_B_lymphoblasts15.95
Adipocyte13.55
AdrenalCortex14.4
Adrenalgland11.9
Amygdala12.55
Appendix37.6
AtrioventricularNode12
BDCA4+_DentriticCells22.6
Bonemarrow15.05
BronchialEpithelialCells18.05
CD105+_Endothelial14.2
CD14+_Monocytes35.7
CD19+_BCells(neg._sel.)15.25
CD33+_Myeloid34.7
CD34+21.05
CD4+_Tcells19.7
CD56+_NKCells53.7
CD71+_EarlyErythroid13.15
CD8+_Tcells13.15
CardiacMyocytes22.65
Caudatenucleus14.2
Cerebellum12.25
CerebellumPeduncles15.65
CiliaryGanglion10.55
CingulateCortex14.4
Colorectaladenocarcinoma13.75
DorsalRootGanglion10.65
FetalThyroid35
Fetalbrain17.85
Fetalliver12.15
Fetallung12.85
GlobusPallidus10.15
Heart17.2
Hypothalamus15.1
Kidney11.25
Leukemia_chronicMyelogenousK-56212.65
Leukemia_promyelocytic-HL-6011.6
Leukemialymphoblastic(MOLT-4)14.45
Liver18.25
Lung15.45
Lymphnode15.35
Lymphoma_burkitts(Daudi)35
Lymphoma_burkitts(Raji)18.8
MedullaOblongata13.15
OccipitalLobe12.35
OlfactoryBulb13.45
Ovary9.3
Pancreas11.1
PancreaticIslet15.1
ParietalLobe14.65
Pituitary16.55
Placenta15.85
Pons13.25
PrefrontalCortex17.45
Prostate16.35
Salivarygland11.25
SkeletalMuscle16
Skin12.3
SmoothMuscle27.15
Spinalcord15.8
SubthalamicNucleus12.7
SuperiorCervicalGanglion19.75
TemporalLobe12.8
Testis13.05
TestisGermCell12.1
TestisIntersitial11.15
TestisLeydigCell13.9
TestisSeminiferousTubule12.25
Thalamus14.1
Thymus17.45
Thyroid33.85
Tongue14.1
Tonsil13.8
Trachea12.85
TrigeminalGanglion17.8
Uterus11.5
UterusCorpus16.1
WholeBlood15.35
Wholebrain12.1
colon12.05
pineal_day17.94
pineal_night16.66
retina21.7
small_intestine13.65
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_7817_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala3.12 ± 1.05
Basal Forebrain2.23 ± 0.3
Basal Part of Pons2.41 ± 0.81
Cerebellar Cortex2.36 ± 0.88
Cerebellar Nuclei2.56 ± 0.6
Claustrum3.2 ± 1
Epithalamus2.44 ± 0.73
Frontal Lobe2.45 ± 0.82
Globus Pallidus2.66 ± 0.51
Hypothalamus2.58 ± 0.76
Insula2.38 ± 0.7
Limbic Lobe2.65 ± 0.68
Mesencephalon2.63 ± 0.8
Myelencephalon2.54 ± 0.74
Occipital Lobe2.57 ± 0.85
Parietal Lobe2.6 ± 0.76
Pontine Tegmentum2.57 ± 0.8
Striatum2.49 ± 0.82
Subthalamus2.46 ± 0.65
Temporal Lobe2.6 ± 0.79
Thalamus2.44 ± 0.74
White Matter2.55 ± 1.13
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Ptpn9CBCerebellum88.6
100
Ptpn9CTXCerebral cortex100
100
Ptpn9HIPHippocampal region83.46
100
Ptpn9HPFHippocampal formation97.17
100
Ptpn9HYHypothalamus76.2
62.65
Ptpn9LSXLateral septal complex54.23
39.92
Ptpn9MBMidbrain64.94
58.15
Ptpn9MYMedulla78.25
81.81
Ptpn9OLFOlfactory bulb100
100
Ptpn9PPons57.95
57.75
Ptpn9PALPallidum67.21
60.94
Ptpn9RHPRetrohippocampal region100
100
Ptpn9sAMYStriatum-like amygdalar nuclei96.21
75.42
Ptpn9STRStriatum89.57
69.7
Ptpn9STRdStriatum dorsal region90.52
70.33
Ptpn9STRvStriatum ventral region99.87
77.28
Ptpn9THThalamus84.41
75.28
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00505599 11 445 455 TTLEIHNTEER Peptide Atlas
PTN9_HUMAN_1 24 1 24 MEPATAPRPDMAPELTPEEEQATK PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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