AutismKB 2.0

Annotation Detail for PTPN13


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Basic Information Top
Gene Symbol:PTPN13 ( DKFZp686J1497,FAP-1,PNP1,PTP-BAS,PTP-BL,PTP1E,PTPL1,PTPLE )
Gene Full Name: protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
Band: 4q21.3
Quick LinksEntrez ID:5783; OMIM: 600267; Uniprot ID:PTN13_HUMAN; ENSEMBL ID: ENSG00000163629; HGNC ID: 9646
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body11 / 70761155
blastocyst7 / 62319112
fetus22 / 56401239
neonate0 / 310970 
infant1 / 2362042
juvenile0 / 555560 
adult78 / 193912140
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma5 / 17475286
breast (mammary gland) tumor0 / 941780 
cervical tumor1 / 3436629
chondrosarcoma4 / 8282348
colorectal tumor1 / 1142468
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor6 / 26384522
glioma3 / 10688328
head and neck tumor7 / 13630251
kidney tumor2 / 6895929
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma1 / 7175513
non-neoplasia4 / 9725041
normal131 / 336030738
ovarian tumor0 / 766820 
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS4 / 12568031
prostate cancer1 / 1026809
retinoblastoma8 / 46356172
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor16 / 125191127
uterine tumor2 / 9025722
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder2 / 2975767
blood0 / 1234780 
bone9 / 71655125
bone marrow0 / 488010 
brain28 / 110098925
cervix1 / 4817120
connective tissue16 / 149255107
ear3 / 16212185
embryonic tissue28 / 215722129
esophagus0 / 202090 
eye24 / 211054113
heart0 / 896260 
intestine2 / 2344728
kidney17 / 21177780
larynx3 / 24145124
liver0 / 2077430 
lung5 / 33697414
lymph0 / 442700 
lymph node1 / 9161010
mammary gland2 / 15327113
mouth4 / 6705259
muscle8 / 10771574
nerve0 / 157680 
ovary0 / 1020510 
pancreas7 / 21481232
parathyroid0 / 205390 
pharynx1 / 4132824
pituitary gland4 / 16585241
placenta3 / 28082510
prostate4 / 18934521
salivary gland0 / 201550 
skin1 / 2105744
spleen0 / 539520 
stomach0 / 966190 
testis14 / 33044242
thymus0 / 811310 
thyroid1 / 4747321
tonsil0 / 169990 
trachea2 / 5241338
umbilical cord0 / 136800 
uterus8 / 23287834
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 204201_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts92.6
Adipocyte58.75
AdrenalCortex43.9
Adrenalgland26.95
Amygdala182.75
Appendix42.5
AtrioventricularNode63.15
BDCA4+_DentriticCells13.65
Bonemarrow31
BronchialEpithelialCells102.65
CD105+_Endothelial18.75
CD14+_Monocytes26.35
CD19+_BCells(neg._sel.)23.2
CD33+_Myeloid26.15
CD34+23.75
CD4+_Tcells18.9
CD56+_NKCells19.15
CD71+_EarlyErythroid19.95
CD8+_Tcells13.45
CardiacMyocytes57.55
Caudatenucleus45.8
Cerebellum22.95
CerebellumPeduncles36.55
CiliaryGanglion38.5
CingulateCortex30.3
Colorectaladenocarcinoma22.95
DorsalRootGanglion30.45
FetalThyroid68.8
Fetalbrain95.5
Fetalliver25.1
Fetallung37.5
GlobusPallidus26.05
Heart56.7
Hypothalamus55.75
Kidney26.3
Leukemia_chronicMyelogenousK-56217.25
Leukemia_promyelocytic-HL-6020.45
Leukemialymphoblastic(MOLT-4)20.15
Liver46.4
Lung30.35
Lymphnode18.4
Lymphoma_burkitts(Daudi)31.35
Lymphoma_burkitts(Raji)38.45
MedullaOblongata23.6
OccipitalLobe59
OlfactoryBulb51.2
Ovary24.35
Pancreas24.4
PancreaticIslet29.1
ParietalLobe32.6
Pituitary104.3
Placenta16.9
Pons31.1
PrefrontalCortex36.65
Prostate47.75
Salivarygland23.7
SkeletalMuscle52.45
Skin117.85
SmoothMuscle32.25
Spinalcord36.25
SubthalamicNucleus30.75
SuperiorCervicalGanglion55.95
TemporalLobe24.75
Testis21.35
TestisGermCell28.4
TestisIntersitial26.3
TestisLeydigCell27
TestisSeminiferousTubule23.85
Thalamus45.65
Thymus18.7
Thyroid289.75
Tongue47.8
Tonsil65.95
Trachea37.3
TrigeminalGanglion47.65
Uterus143.3
UterusCorpus35.1
WholeBlood18.05
Wholebrain17.1
colon18
pineal_day835.72
pineal_night593.44
retina121.175
small_intestine16.6
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_13919_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala7.6 ± 0.25
Basal Forebrain7.53 ± 0.18
Basal Part of Pons6.74 ± 0.28
Cerebellar Cortex7.16 ± 0.49
Cerebellar Nuclei7.1 ± 0.28
Claustrum7.22 ± 0.33
Epithalamus7.64 ± 0.25
Frontal Lobe7.48 ± 0.38
Globus Pallidus8.61 ± 0.42
Hypothalamus7.02 ± 0.28
Insula7.27 ± 0.44
Limbic Lobe7.78 ± 0.52
Mesencephalon7.62 ± 0.48
Myelencephalon7.56 ± 0.49
Occipital Lobe7.59 ± 0.38
Parietal Lobe7.51 ± 0.39
Pontine Tegmentum7.63 ± 0.29
Striatum8.07 ± 0.38
Subthalamus7.08 ± 0.14
Temporal Lobe7.55 ± 0.33
Thalamus7.49 ± 0.31
White Matter9.02 ± 0.26
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Ptpn13CBCerebellum16.2
19.09
Ptpn13CTXCerebral cortex2.05
1.65
Ptpn13HIPHippocampal region2.21
3.48
Ptpn13HPFHippocampal formation1.6
2.46
Ptpn13HYHypothalamus1.11
1.29
Ptpn13LSXLateral septal complex1.08
0.81
Ptpn13MBMidbrain3.5
4.45
Ptpn13MYMedulla3.05
3.05
Ptpn13OLFOlfactory bulb10.63
7.48
Ptpn13PPons3.1
3.27
Ptpn13PALPallidum0.36
0.58
Ptpn13RHPRetrohippocampal region0.36
0.77
Ptpn13sAMYStriatum-like amygdalar nuclei0.73
0.95
Ptpn13STRStriatum0.91
0.77
Ptpn13STRdStriatum dorsal region0.43
0.44
Ptpn13STRvStriatum ventral region2.42
1.57
Ptpn13THThalamus0.89
0.95
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00095720 23 1268 1290 EHVPVTPQCTLSDQNAQGQGPEK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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