AutismKB 2.0

Annotation Detail for PTPRB


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Basic Information Top
Gene Symbol:PTPRB ( DKFZp686E2262,DKFZp686H15164,FLJ44133,HPTP-BETA,HPTPB,MGC142023,MGC59935,PTPB,R-PTP-BETA,VEPTP )
Gene Full Name: protein tyrosine phosphatase, receptor type, B
Band: 12q15
Quick LinksEntrez ID:5787; OMIM: 176882; Uniprot ID:PTPRB_HUMAN; ENSEMBL ID: ENSG00000127329; HGNC ID: 9665
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus16 / 56401228
neonate2 / 3109764
infant0 / 236200 
juvenile0 / 555560 
adult34 / 193912117
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor2 / 9417821
cervical tumor1 / 3436629
chondrosarcoma5 / 8282360
colorectal tumor1 / 1142468
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor2 / 2638457
glioma0 / 1068830 
head and neck tumor1 / 1363027
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia1 / 9725010
normal88 / 336030726
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor1 / 1249498
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor3 / 9025733
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland0 / 331970 
ascites0 / 400150 
bladder2 / 2975767
blood0 / 1234780 
bone0 / 716550 
bone marrow0 / 488010 
brain16 / 110098914
cervix1 / 4817120
connective tissue6 / 14925540
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus0 / 202090 
eye2 / 2110549
heart4 / 8962644
intestine3 / 23447212
kidney15 / 21177770
larynx0 / 241450 
liver3 / 20774314
lung9 / 33697426
lymph0 / 442700 
lymph node0 / 916100 
mammary gland2 / 15327113
mouth0 / 670520 
muscle5 / 10771546
nerve0 / 157680 
ovary0 / 1020510 
pancreas0 / 2148120 
parathyroid1 / 2053948
pharynx1 / 4132824
pituitary gland0 / 165850 
placenta10 / 28082535
prostate1 / 1893455
salivary gland0 / 201550 
skin1 / 2105744
spleen3 / 5395255
stomach0 / 966190 
testis0 / 3304420 
thymus3 / 8113136
thyroid0 / 474730 
tonsil0 / 169990 
trachea2 / 5241338
umbilical cord2 / 13680146
uterus4 / 23287817
vascular2 / 5178038
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 217177_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts8.1
Adipocyte7.65
AdrenalCortex10.8
Adrenalgland7.15
Amygdala7.8
Appendix13.9
AtrioventricularNode11.15
BDCA4+_DentriticCells7.25
Bonemarrow9.2
BronchialEpithelialCells7.35
CD105+_Endothelial7.55
CD14+_Monocytes8.3
CD19+_BCells(neg._sel.)7.7
CD33+_Myeloid9.1
CD34+8.9
CD4+_Tcells7.55
CD56+_NKCells8.3
CD71+_EarlyErythroid7.55
CD8+_Tcells6.65
CardiacMyocytes15
Caudatenucleus7.1
Cerebellum6.6
CerebellumPeduncles10.1
CiliaryGanglion6.4
CingulateCortex8.25
Colorectaladenocarcinoma7.8
DorsalRootGanglion9.2
FetalThyroid8.55
Fetalbrain7.25
Fetalliver7.05
Fetallung5.9
GlobusPallidus6.65
Heart12.45
Hypothalamus8.5
Kidney7.7
Leukemia_chronicMyelogenousK-5627
Leukemia_promyelocytic-HL-606.8
Leukemialymphoblastic(MOLT-4)5.9
Liver13.8
Lung8.5
Lymphnode6.35
Lymphoma_burkitts(Daudi)10.45
Lymphoma_burkitts(Raji)12.75
MedullaOblongata7.1
OccipitalLobe7
OlfactoryBulb6.25
Ovary6.25
Pancreas6.85
PancreaticIslet8.65
ParietalLobe9.5
Pituitary9
Placenta7.65
Pons8.1
PrefrontalCortex9.05
Prostate8.6
Salivarygland6.75
SkeletalMuscle13.7
Skin7.2
SmoothMuscle8.8
Spinalcord8.35
SubthalamicNucleus8.2
SuperiorCervicalGanglion17.7
TemporalLobe7.8
Testis6.75
TestisGermCell6.15
TestisIntersitial6.8
TestisLeydigCell8.4
TestisSeminiferousTubule6.7
Thalamus8.2
Thymus5.85
Thyroid9.35
Tongue9.15
Tonsil7.95
Trachea6.45
TrigeminalGanglion17.9
Uterus7.75
UterusCorpus19.65
WholeBlood8.45
Wholebrain6.2
colon7.7
pineal_day9.6
pineal_night9.38
retina9.375
small_intestine7.1
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P53390
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.11 ± 0.27
Basal Forebrain6.27 ± 0.3
Basal Part of Pons6 ± 0.28
Cerebellar Cortex6.55 ± 0.14
Cerebellar Nuclei7 ± 0.34
Claustrum6.05 ± 0.58
Epithalamus5.9 ± 0.44
Frontal Lobe6.32 ± 0.41
Globus Pallidus7.12 ± 0.16
Hypothalamus6.03 ± 0.4
Insula6.47 ± 0.29
Limbic Lobe6.36 ± 0.45
Mesencephalon6.58 ± 0.41
Myelencephalon6.45 ± 0.47
Occipital Lobe6.58 ± 0.5
Parietal Lobe6.15 ± 0.47
Pontine Tegmentum6.53 ± 0.48
Striatum6.7 ± 0.53
Subthalamus6.76 ± 0.34
Temporal Lobe6.38 ± 0.38
Thalamus6.6 ± 0.35
White Matter6.5 ± 0.53
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
PtprbCBCerebellum68.55
96.34
PtprbCTXCerebral cortex30.55
24.95
PtprbHIPHippocampal region27.84
33.67
PtprbHPFHippocampal formation33.88
36.69
PtprbHYHypothalamus12.58
13.29
PtprbLSXLateral septal complex21.61
19.58
PtprbMBMidbrain16.3
22.42
PtprbMYMedulla23.54
28.23
PtprbOLFOlfactory bulb38.8
33.02
PtprbPPons17.73
21.86
PtprbPALPallidum16.67
18.94
PtprbRHPRetrohippocampal region42.82
39.65
PtprbsAMYStriatum-like amygdalar nuclei20.48
20.28
PtprbSTRStriatum25.18
22.49
PtprbSTRdStriatum dorsal region26.45
23.9
PtprbSTRvStriatum ventral region25
20.08
PtprbTHThalamus13.61
17
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00377217 21 93 113 WTCYDQEGFLEVENASLFLQK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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