AutismKB 2.0

Annotation Detail for PTPRK


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Basic Information Top
Gene Symbol:PTPRK ( DKFZp686C2268,DKFZp779N1045,R-PTP-kappa )
Gene Full Name: protein tyrosine phosphatase, receptor type, K
Band: 6q22.33
Quick LinksEntrez ID:5796; OMIM: 602545; Uniprot ID:PTPRK_HUMAN; ENSEMBL ID: ENSG00000152894; HGNC ID: 9674
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body5 / 7076170
blastocyst6 / 6231996
fetus41 / 56401272
neonate0 / 310970 
infant0 / 236200 
juvenile1 / 5555617
adult94 / 193912148
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma1 / 1747557
breast (mammary gland) tumor3 / 9417831
cervical tumor0 / 343660 
chondrosarcoma3 / 8282336
colorectal tumor12 / 114246105
esophageal tumor1 / 1729057
gastrointestinal tumor4 / 11936933
germ cell tumor11 / 26384541
glioma8 / 10688374
head and neck tumor19 / 136302139
kidney tumor1 / 6895914
leukemia0 / 958420 
liver tumor1 / 9635910
lung tumor3 / 10312729
lymphoma0 / 717550 
non-neoplasia2 / 9725020
normal148 / 336030744
ovarian tumor2 / 7668226
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS2 / 12568015
prostate cancer1 / 1026809
retinoblastoma0 / 463560 
skin tumor1 / 1249498
soft tissue/muscle tissue tumor4 / 12519131
uterine tumor6 / 9025766
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland1 / 3319730
ascites0 / 400150 
bladder2 / 2975767
blood0 / 1234780 
bone3 / 7165541
bone marrow0 / 488010 
brain48 / 110098943
cervix0 / 481710 
connective tissue4 / 14925526
ear0 / 162120 
embryonic tissue18 / 21572283
esophagus1 / 2020949
eye3 / 21105414
heart4 / 8962644
intestine21 / 23447289
kidney14 / 21177766
larynx2 / 2414582
liver7 / 20774333
lung17 / 33697450
lymph0 / 442700 
lymph node0 / 916100 
mammary gland8 / 15327152
mouth6 / 6705289
muscle2 / 10771518
nerve0 / 157680 
ovary3 / 10205129
pancreas9 / 21481241
parathyroid0 / 205390 
pharynx11 / 41328266
pituitary gland1 / 1658560
placenta9 / 28082532
prostate3 / 18934515
salivary gland0 / 201550 
skin5 / 21057423
spleen0 / 539520 
stomach4 / 9661941
testis4 / 33044212
thymus1 / 8113112
thyroid1 / 4747321
tonsil1 / 1699958
trachea0 / 524130 
umbilical cord0 / 136800 
uterus9 / 23287838
vascular3 / 5178057
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 203038_at
Cell line Expression level Expression bar
721_B_lymphoblasts24.65
Adipocyte5.1
AdrenalCortex3.9
Adrenalgland3.2
Amygdala100.05
Appendix4.55
AtrioventricularNode3.45
BDCA4+_DentriticCells3.9
Bonemarrow3.4
BronchialEpithelialCells275.7
CD105+_Endothelial3.8
CD14+_Monocytes3.75
CD19+_BCells(neg._sel.)94.25
CD33+_Myeloid4.6
CD34+5.25
CD4+_Tcells3.9
CD56+_NKCells4.05
CD71+_EarlyErythroid3.45
CD8+_Tcells4.4
CardiacMyocytes15.75
Caudatenucleus21.65
Cerebellum3.4
CerebellumPeduncles7.1
CiliaryGanglion4.8
CingulateCortex75.6
Colorectaladenocarcinoma4.2
DorsalRootGanglion3.3
FetalThyroid4.9
Fetalbrain317.85
Fetalliver16.2
Fetallung151.85
GlobusPallidus53.85
Heart4.25
Hypothalamus116.1
Kidney3.65
Leukemia_chronicMyelogenousK-5623.25
Leukemia_promyelocytic-HL-603.2
Leukemialymphoblastic(MOLT-4)44.75
Liver5.5
Lung10.6
Lymphnode7.65
Lymphoma_burkitts(Daudi)4.4
Lymphoma_burkitts(Raji)5.6
MedullaOblongata61.65
OccipitalLobe98.75
OlfactoryBulb4.1
Ovary4.25
Pancreas38.7
PancreaticIslet65.5
ParietalLobe81
Pituitary11.8
Placenta14
Pons21.25
PrefrontalCortex336.5
Prostate46.4
Salivarygland45.25
SkeletalMuscle3.95
Skin4.2
SmoothMuscle75.7
Spinalcord49
SubthalamicNucleus55.4
SuperiorCervicalGanglion4.4
TemporalLobe37.15
Testis3.15
TestisGermCell3.4
TestisIntersitial3.2
TestisLeydigCell3.55
TestisSeminiferousTubule3.15
Thalamus31.8
Thymus3.65
Thyroid8.85
Tongue4.25
Tonsil4.45
Trachea20.2
TrigeminalGanglion3.9
Uterus30.95
UterusCorpus4.05
WholeBlood3.85
Wholebrain48.65
colon95.45
pineal_day4.84
pineal_night4.5
retina36.075
small_intestine51
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_32_P99100
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala10.12 ± 0.42
Basal Forebrain9.64 ± 0.25
Basal Part of Pons9.91 ± 0.33
Cerebellar Cortex9.64 ± 0.24
Cerebellar Nuclei10.54 ± 0.19
Claustrum10.36 ± 0.29
Epithalamus10 ± 0.37
Frontal Lobe10.36 ± 0.33
Globus Pallidus10.25 ± 0.51
Hypothalamus9.86 ± 0.34
Insula10.2 ± 0.31
Limbic Lobe10.11 ± 0.64
Mesencephalon9.96 ± 0.51
Myelencephalon10.03 ± 0.5
Occipital Lobe9.83 ± 0.5
Parietal Lobe10.23 ± 0.47
Pontine Tegmentum10.32 ± 0.35
Striatum9.31 ± 0.79
Subthalamus10.49 ± 0.4
Temporal Lobe10.15 ± 0.3
Thalamus9.78 ± 0.37
White Matter11.18 ± 0.17
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
PtprkCBCerebellum12.34
12.74
PtprkCTXCerebral cortex64.05
54.44
PtprkHIPHippocampal region30.29
43.17
PtprkHPFHippocampal formation42.36
53.34
PtprkHYHypothalamus13.09
10.56
PtprkLSXLateral septal complex9.31
7.99
PtprkMBMidbrain12.9
12.01
PtprkMYMedulla12.42
12.3
PtprkOLFOlfactory bulb56.12
51.44
PtprkPPons9.67
9.09
PtprkPALPallidum8.27
7.03
PtprkRHPRetrohippocampal region58.86
63.96
PtprksAMYStriatum-like amygdalar nuclei9.62
6.74
PtprkSTRStriatum4.94
4.39
PtprkSTRdStriatum dorsal region3.63
3.41
PtprkSTRvStriatum ventral region5.22
5.14
PtprkTHThalamus6.34
6.47
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00040148 37 290 326 EPPRPIAPPQLLGVGPTYLLIQLNANSIIGDGPIILK Peptide Atlas
PTPRK_HUMAN_792 12 792 803 QEMTHMVNAMDR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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