AutismKB 2.0

Annotation Detail for PTPRM


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Basic Information Top
Gene Symbol:PTPRM ( MGC166994,PTPRL1,R-PTP-MU,RPTPM,RPTPU,hR-PTPu )
Gene Full Name: protein tyrosine phosphatase, receptor type, M
Band: 18p11.23
Quick LinksEntrez ID:5797; OMIM: 176888; Uniprot ID:PTPRM_HUMAN; ENSEMBL ID: ENSG00000173482; HGNC ID: 9675
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst2 / 6231932
fetus20 / 56401235
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult151 / 193912177
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma2 / 17475114
breast (mammary gland) tumor5 / 9417853
cervical tumor4 / 34366116
chondrosarcoma13 / 82823156
colorectal tumor1 / 1142468
esophageal tumor0 / 172900 
gastrointestinal tumor2 / 11936916
germ cell tumor4 / 26384515
glioma0 / 1068830 
head and neck tumor24 / 136302176
kidney tumor5 / 6895972
leukemia0 / 958420 
liver tumor1 / 9635910
lung tumor1 / 1031279
lymphoma0 / 717550 
non-neoplasia2 / 9725020
normal196 / 336030758
ovarian tumor0 / 766820 
pancreatic tumor2 / 10461619
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer2 / 10268019
retinoblastoma0 / 463560 
skin tumor3 / 12494924
soft tissue/muscle tissue tumor16 / 125191127
uterine tumor6 / 9025766
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites2 / 4001549
bladder2 / 2975767
blood0 / 1234780 
bone11 / 71655153
bone marrow0 / 488010 
brain71 / 110098964
cervix4 / 4817183
connective tissue8 / 14925553
ear0 / 162120 
embryonic tissue4 / 21572218
esophagus0 / 202090 
eye15 / 21105471
heart4 / 8962644
intestine2 / 2344728
kidney12 / 21177756
larynx0 / 241450 
liver1 / 2077434
lung11 / 33697432
lymph0 / 442700 
lymph node2 / 9161021
mammary gland8 / 15327152
mouth0 / 670520 
muscle6 / 10771555
nerve2 / 15768126
ovary1 / 1020519
pancreas6 / 21481227
parathyroid1 / 2053948
pharynx1 / 4132824
pituitary gland2 / 16585120
placenta17 / 28082560
prostate10 / 18934552
salivary gland0 / 201550 
skin12 / 21057456
spleen0 / 539520 
stomach0 / 966190 
testis35 / 330442105
thymus13 / 81131160
thyroid29 / 47473610
tonsil0 / 169990 
trachea3 / 5241357
umbilical cord0 / 136800 
uterus14 / 23287860
vascular2 / 5178038
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 203329_at
Cell line Expression level Expression bar
721_B_lymphoblasts14.2
Adipocyte58
AdrenalCortex15.65
Adrenalgland22.25
Amygdala33.85
Appendix15
AtrioventricularNode10.4
BDCA4+_DentriticCells15.15
Bonemarrow13.5
BronchialEpithelialCells16.5
CD105+_Endothelial13.25
CD14+_Monocytes13.1
CD19+_BCells(neg._sel.)13.2
CD33+_Myeloid12.4
CD34+10.5
CD4+_Tcells13.5
CD56+_NKCells14.35
CD71+_EarlyErythroid12.25
CD8+_Tcells12.6
CardiacMyocytes16.55
Caudatenucleus35.55
Cerebellum13.35
CerebellumPeduncles15.6
CiliaryGanglion10
CingulateCortex26.75
Colorectaladenocarcinoma12.7
DorsalRootGanglion11.35
FetalThyroid87.15
Fetalbrain17.35
Fetalliver12.1
Fetallung44.1
GlobusPallidus10.75
Heart23.8
Hypothalamus68.9
Kidney15.8
Leukemia_chronicMyelogenousK-56211.7
Leukemia_promyelocytic-HL-6010.9
Leukemialymphoblastic(MOLT-4)9.65
Liver18.3
Lung34.45
Lymphnode29.25
Lymphoma_burkitts(Daudi)16.15
Lymphoma_burkitts(Raji)17.5
MedullaOblongata12.85
OccipitalLobe20.2
OlfactoryBulb10.5
Ovary10
Pancreas10.65
PancreaticIslet14.95
ParietalLobe14.35
Pituitary26.75
Placenta34.6
Pons12.9
PrefrontalCortex47.45
Prostate17.65
Salivarygland11.05
SkeletalMuscle14.95
Skin9.9
SmoothMuscle21.1
Spinalcord18.95
SubthalamicNucleus15.45
SuperiorCervicalGanglion13.85
TemporalLobe12.85
Testis13.5
TestisGermCell30.05
TestisIntersitial22.75
TestisLeydigCell15.55
TestisSeminiferousTubule14.3
Thalamus78.25
Thymus26.95
Thyroid97
Tongue12.65
Tonsil13
Trachea11
TrigeminalGanglion14.15
Uterus27.95
UterusCorpus12.4
WholeBlood13.55
Wholebrain20.1
colon13
pineal_day18.46
pineal_night16.48
retina42.725
small_intestine12.8
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_9774_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.27 ± 0.49
Basal Forebrain3.82 ± 0.7
Basal Part of Pons4.16 ± 0.4
Cerebellar Cortex4.04 ± 0.5
Cerebellar Nuclei4.37 ± 0.45
Claustrum4.26 ± 0.55
Epithalamus3.87 ± 0.47
Frontal Lobe4.17 ± 0.48
Globus Pallidus4.12 ± 0.55
Hypothalamus4.46 ± 0.46
Insula4.16 ± 0.42
Limbic Lobe4.07 ± 0.52
Mesencephalon4.37 ± 0.61
Myelencephalon4.21 ± 0.47
Occipital Lobe4.04 ± 0.58
Parietal Lobe4.31 ± 0.49
Pontine Tegmentum4.3 ± 0.58
Striatum4.96 ± 0.4
Subthalamus4.76 ± 0.69
Temporal Lobe4.11 ± 0.4
Thalamus4.49 ± 0.5
White Matter3.01 ± 0.27
Mouse Brain ISH
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00139597 8 700 707 IYFQAASR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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