AutismKB 2.0

Annotation Detail for PTPRN2


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Basic Information Top
Gene Symbol:PTPRN2 ( IA-2beta,IAR,ICAAR,PTPRP )
Gene Full Name: protein tyrosine phosphatase, receptor type, N polypeptide 2
Band: 7q36.3
Quick LinksEntrez ID:5799; OMIM: 601698; Uniprot ID:PTPR2_HUMAN; ENSEMBL ID: ENSG00000155093; HGNC ID: 9677
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst1 / 6231916
fetus36 / 56401263
neonate0 / 310970 
infant2 / 2362084
juvenile4 / 5555671
adult130 / 193912167
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma0 / 174750 
breast (mammary gland) tumor4 / 9417842
cervical tumor0 / 343660 
chondrosarcoma1 / 8282312
colorectal tumor3 / 11424626
esophageal tumor1 / 1729057
gastrointestinal tumor4 / 11936933
germ cell tumor5 / 26384518
glioma10 / 10688393
head and neck tumor3 / 13630222
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia10 / 97250102
normal287 / 336030785
ovarian tumor0 / 766820 
pancreatic tumor4 / 10461638
primitive neuroectodermal tumor of the CNS7 / 12568055
prostate cancer2 / 10268019
retinoblastoma0 / 463560 
skin tumor2 / 12494916
soft tissue/muscle tissue tumor4 / 12519131
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland4 / 33197120
ascites0 / 400150 
bladder1 / 2975733
blood3 / 12347824
bone0 / 716550 
bone marrow1 / 4880120
brain182 / 1100989165
cervix1 / 4817120
connective tissue6 / 14925540
ear0 / 162120 
embryonic tissue4 / 21572218
esophagus1 / 2020949
eye10 / 21105447
heart0 / 896260 
intestine9 / 23447238
kidney8 / 21177737
larynx0 / 241450 
liver1 / 2077434
lung17 / 33697450
lymph0 / 442700 
lymph node3 / 9161032
mammary gland4 / 15327126
mouth1 / 6705214
muscle0 / 1077150 
nerve2 / 15768126
ovary1 / 1020519
pancreas31 / 214812144
parathyroid1 / 2053948
pharynx2 / 4132848
pituitary gland5 / 16585301
placenta9 / 28082532
prostate9 / 18934547
salivary gland0 / 201550 
skin2 / 2105749
spleen7 / 53952129
stomach5 / 9661951
testis17 / 33044251
thymus1 / 8113112
thyroid2 / 4747342
tonsil0 / 169990 
trachea2 / 5241338
umbilical cord0 / 136800 
uterus3 / 23287812
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 203029_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts9.25
Adipocyte8.6
AdrenalCortex10.85
Adrenalgland8.8
Amygdala422.85
Appendix12.15
AtrioventricularNode9.45
BDCA4+_DentriticCells7
Bonemarrow10.5
BronchialEpithelialCells9.35
CD105+_Endothelial8.4
CD14+_Monocytes10.8
CD19+_BCells(neg._sel.)22.65
CD33+_Myeloid9.75
CD34+9.3
CD4+_Tcells7.85
CD56+_NKCells15.4
CD71+_EarlyErythroid7.35
CD8+_Tcells6.9
CardiacMyocytes11.15
Caudatenucleus273.55
Cerebellum36.2
CerebellumPeduncles73.1
CiliaryGanglion8
CingulateCortex178.9
Colorectaladenocarcinoma123.4
DorsalRootGanglion9.25
FetalThyroid11
Fetalbrain162.6
Fetalliver8.05
Fetallung8.45
GlobusPallidus85.9
Heart11.7
Hypothalamus298.5
Kidney7.25
Leukemia_chronicMyelogenousK-5628.1
Leukemia_promyelocytic-HL-607.75
Leukemialymphoblastic(MOLT-4)53.75
Liver13.15
Lung26.65
Lymphnode9.4
Lymphoma_burkitts(Daudi)10.35
Lymphoma_burkitts(Raji)12.85
MedullaOblongata128.35
OccipitalLobe258.6
OlfactoryBulb14.65
Ovary8.15
Pancreas19.25
PancreaticIslet126.05
ParietalLobe190
Pituitary168.55
Placenta8.5
Pons35.8
PrefrontalCortex322.35
Prostate71.3
Salivarygland7.7
SkeletalMuscle9.85
Skin7.8
SmoothMuscle10.3
Spinalcord46.95
SubthalamicNucleus228.9
SuperiorCervicalGanglion15.35
TemporalLobe144.6
Testis8.15
TestisGermCell9.1
TestisIntersitial7
TestisLeydigCell10.7
TestisSeminiferousTubule8.25
Thalamus214.7
Thymus7
Thyroid38.7
Tongue9.75
Tonsil8.8
Trachea38.35
TrigeminalGanglion11.85
Uterus7.75
UterusCorpus10.55
WholeBlood10.85
Wholebrain526.65
colon12.2
pineal_day85.3
pineal_night106.44
retina51.125
small_intestine10.4
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_32_P66804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala10.48 ± 0.47
Basal Forebrain9.83 ± 0.27
Basal Part of Pons9.71 ± 0.47
Cerebellar Cortex9.03 ± 0.29
Cerebellar Nuclei8.79 ± 0.78
Claustrum10.52 ± 0.59
Epithalamus8.08 ± 1.02
Frontal Lobe9.59 ± 0.67
Globus Pallidus8.91 ± 0.98
Hypothalamus9.45 ± 0.5
Insula9.67 ± 0.39
Limbic Lobe10.33 ± 0.52
Mesencephalon9.58 ± 0.71
Myelencephalon9.68 ± 0.71
Occipital Lobe10.13 ± 0.62
Parietal Lobe9.8 ± 0.73
Pontine Tegmentum9.62 ± 0.59
Striatum10.61 ± 0.41
Subthalamus9.3 ± 0.02
Temporal Lobe9.76 ± 0.54
Thalamus9.74 ± 0.44
White Matter7.51 ± 1.01
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Ptprn2CBCerebellum31.4
46.07
Ptprn2CTXCerebral cortex72.25
57.24
Ptprn2HIPHippocampal region43.3
60.46
Ptprn2HPFHippocampal formation58.64
65.94
Ptprn2HYHypothalamus29.53
23.66
Ptprn2LSXLateral septal complex34.45
25.33
Ptprn2MBMidbrain38.03
33.09
Ptprn2MYMedulla13.12
12.46
Ptprn2OLFOlfactory bulb56.69
47.42
Ptprn2PPons23.7
20.97
Ptprn2PALPallidum26.84
22.59
Ptprn2RHPRetrohippocampal region85.69
75.91
Ptprn2sAMYStriatum-like amygdalar nuclei38.82
28.47
Ptprn2STRStriatum35.74
26.97
Ptprn2STRdStriatum dorsal region31.37
24.71
Ptprn2STRvStriatum ventral region46.38
31.37
Ptprn2THThalamus57.27
49
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PTPR2_HUMAN_673 35 673 707 MATRPPDRPEGPHTSRISSVSSQFSDGPIPSPSAR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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