AutismKB 2.0

Annotation Detail for PTPRS


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Basic Information Top
Gene Symbol:PTPRS ( PTPSIGMA )
Gene Full Name: protein tyrosine phosphatase, receptor type, S
Band: 19p13.3
Quick LinksEntrez ID:5802; OMIM: 601576; Uniprot ID:PTPRS_HUMAN; ENSEMBL ID: ENSG00000105426; HGNC ID: 9681
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 210823_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts5.85
Adipocyte4.65
AdrenalCortex5.15
Adrenalgland4
Amygdala5
Appendix4.65
AtrioventricularNode3.65
BDCA4+_DentriticCells24.1
Bonemarrow4.75
BronchialEpithelialCells4.6
CD105+_Endothelial4.7
CD14+_Monocytes5
CD19+_BCells(neg._sel.)4.95
CD33+_Myeloid6
CD34+5.95
CD4+_Tcells5.15
CD56+_NKCells5.55
CD71+_EarlyErythroid4.4
CD8+_Tcells4.45
CardiacMyocytes6.15
Caudatenucleus4.2
Cerebellum3.75
CerebellumPeduncles5.35
CiliaryGanglion3.3
CingulateCortex4.8
Colorectaladenocarcinoma4.7
DorsalRootGanglion3.75
FetalThyroid4.5
Fetalbrain4.65
Fetalliver4.05
Fetallung3.75
GlobusPallidus3.85
Heart6.35
Hypothalamus5.1
Kidney3.85
Leukemia_chronicMyelogenousK-5624.25
Leukemia_promyelocytic-HL-604.1
Leukemialymphoblastic(MOLT-4)3.7
Liver6.3
Lung5.1
Lymphnode4
Lymphoma_burkitts(Daudi)6.1
Lymphoma_burkitts(Raji)6.6
MedullaOblongata4.25
OccipitalLobe4.2
OlfactoryBulb3.7
Ovary3.1
Pancreas3.75
PancreaticIslet5
ParietalLobe5.05
Pituitary5.4
Placenta4.8
Pons4.55
PrefrontalCortex5.85
Prostate5.5
Salivarygland3.8
SkeletalMuscle5.5
Skin3.65
SmoothMuscle5.3
Spinalcord4.95
SubthalamicNucleus4.6
SuperiorCervicalGanglion5.35
TemporalLobe4.3
Testis3.95
TestisGermCell3.85
TestisIntersitial3.9
TestisLeydigCell4.6
TestisSeminiferousTubule4
Thalamus4.8
Thymus3.65
Thyroid5.85
Tongue4.65
Tonsil4.55
Trachea3.9
TrigeminalGanglion4.7
Uterus3.8
UterusCorpus4.2
WholeBlood5.1
Wholebrain3.95
colon4.7
pineal_day5.82
pineal_night5.72
retina5.65
small_intestine4.55
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P290856
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala7.51 ± 0.44
Basal Forebrain7.23 ± 0.4
Basal Part of Pons7.73 ± 0.36
Cerebellar Cortex6.91 ± 0.27
Cerebellar Nuclei6.67 ± 0.25
Claustrum7.92 ± 0.56
Epithalamus6.44 ± 0.37
Frontal Lobe7.08 ± 0.45
Globus Pallidus7.32 ± 0.55
Hypothalamus6.74 ± 0.33
Insula7.1 ± 0.43
Limbic Lobe7.58 ± 0.46
Mesencephalon7.01 ± 0.45
Myelencephalon7.17 ± 0.44
Occipital Lobe7.55 ± 0.47
Parietal Lobe7.26 ± 0.49
Pontine Tegmentum7.03 ± 0.43
Striatum6.82 ± 0.53
Subthalamus6.64 ± 0.37
Temporal Lobe7.23 ± 0.42
Thalamus7.31 ± 0.39
White Matter7.36 ± 0.63
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
PtprsCBCerebellum63.57
76.33
PtprsCTXCerebral cortex100
100
PtprsHIPHippocampal region100
100
PtprsHPFHippocampal formation100
100
PtprsHYHypothalamus99.19
96.94
PtprsLSXLateral septal complex100
100
PtprsMBMidbrain100
93.86
PtprsMYMedulla100
98.21
PtprsOLFOlfactory bulb100
100
PtprsPPons100
98.55
PtprsPALPallidum100
100
PtprsRHPRetrohippocampal region100
100
PtprssAMYStriatum-like amygdalar nuclei100
100
PtprsSTRStriatum100
88.38
PtprsSTRdStriatum dorsal region100
76.69
PtprsSTRvStriatum ventral region100
91.3
PtprsTHThalamus100
100
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00039708 20 1301 1320 CLLNNADLAPHHPKDPVEMR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018