AutismKB 2.0

Annotation Detail for PTPRZ1


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Basic Information Top
Gene Symbol:PTPRZ1 ( HPTPZ,HPTPzeta,PTP-ZETA,PTP18,PTPRZ,PTPZ,RPTPB,RPTPbeta,phosphacan )
Gene Full Name: protein tyrosine phosphatase, receptor-type, Z polypeptide 1
Band: 7q31.32
Quick LinksEntrez ID:5803; OMIM: 176891; Uniprot ID:PTPRZ_HUMAN; ENSEMBL ID: ENSG00000106278; HGNC ID: 9685
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst21 / 62319336
fetus103 / 564012182
neonate0 / 310970 
infant1 / 2362042
juvenile0 / 555560 
adult73 / 193912137
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor4 / 11424635
esophageal tumor0 / 172900 
gastrointestinal tumor2 / 11936916
germ cell tumor28 / 263845106
glioma30 / 106883280
head and neck tumor22 / 136302161
kidney tumor3 / 6895943
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia4 / 9725041
normal285 / 336030784
ovarian tumor1 / 7668213
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS1 / 1256807
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor4 / 12519131
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone0 / 716550 
bone marrow0 / 488010 
brain241 / 1100989218
cervix0 / 481710 
connective tissue4 / 14925526
ear0 / 162120 
embryonic tissue34 / 215722157
esophagus0 / 202090 
eye8 / 21105437
heart1 / 8962611
intestine6 / 23447225
kidney3 / 21177714
larynx1 / 2414541
liver0 / 2077430 
lung6 / 33697417
lymph0 / 442700 
lymph node0 / 916100 
mammary gland0 / 1532710 
mouth21 / 67052313
muscle8 / 10771574
nerve1 / 1576863
ovary1 / 1020519
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland1 / 1658560
placenta0 / 2808250 
prostate0 / 1893450 
salivary gland0 / 201550 
skin6 / 21057428
spleen0 / 539520 
stomach0 / 966190 
testis11 / 33044233
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea8 / 52413152
umbilical cord0 / 136800 
uterus0 / 2328780 
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 204469_at
Cell line Expression level Expression bar
721_B_lymphoblasts8.15
Adipocyte7.35
AdrenalCortex9.35
Adrenalgland6.75
Amygdala1835.35
Appendix13.1
AtrioventricularNode8.85
BDCA4+_DentriticCells7.2
Bonemarrow8
BronchialEpithelialCells7.15
CD105+_Endothelial7.4
CD14+_Monocytes7.95
CD19+_BCells(neg._sel.)7.7
CD33+_Myeloid8.9
CD34+8.9
CD4+_Tcells7.7
CD56+_NKCells8.4
CD71+_EarlyErythroid7.15
CD8+_Tcells6.8
CardiacMyocytes11.85
Caudatenucleus396.95
Cerebellum100.2
CerebellumPeduncles126.4
CiliaryGanglion10
CingulateCortex222.05
Colorectaladenocarcinoma7.55
DorsalRootGanglion9.35
FetalThyroid7.75
Fetalbrain1710.25
Fetalliver6.65
Fetallung5.75
GlobusPallidus105.1
Heart11.45
Hypothalamus866.9
Kidney6.8
Leukemia_chronicMyelogenousK-5626.7
Leukemia_promyelocytic-HL-606.65
Leukemialymphoblastic(MOLT-4)5.8
Liver11.15
Lung8.15
Lymphnode6.15
Lymphoma_burkitts(Daudi)9.9
Lymphoma_burkitts(Raji)11.55
MedullaOblongata171.35
OccipitalLobe329.7
OlfactoryBulb14.45
Ovary7.65
Pancreas6.3
PancreaticIslet8.4
ParietalLobe94.5
Pituitary8.95
Placenta7.35
Pons95.05
PrefrontalCortex502.9
Prostate8.55
Salivarygland6.3
SkeletalMuscle11.7
Skin11.7
SmoothMuscle8.35
Spinalcord573.65
SubthalamicNucleus83.45
SuperiorCervicalGanglion19.75
TemporalLobe62.85
Testis6.45
TestisGermCell5.95
TestisIntersitial6.45
TestisLeydigCell8.05
TestisSeminiferousTubule6.4
Thalamus284.6
Thymus5.65
Thyroid8.95
Tongue9.45
Tonsil7.45
Trachea57.55
TrigeminalGanglion11.75
Uterus5.95
UterusCorpus8.25
WholeBlood8.15
Wholebrain401.55
colon7.55
pineal_day189.5
pineal_night115.84
retina188.1
small_intestine7.15
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P8474
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.51 ± 0.33
Basal Forebrain6.36 ± 0.21
Basal Part of Pons5.43 ± 0.66
Cerebellar Cortex5.52 ± 0.29
Cerebellar Nuclei5.77 ± 0.61
Claustrum5.3 ± 0.53
Epithalamus5.88 ± 0.49
Frontal Lobe5.92 ± 0.43
Globus Pallidus7.14 ± 0.47
Hypothalamus5.83 ± 0.36
Insula5.96 ± 0.31
Limbic Lobe5.99 ± 0.54
Mesencephalon6.21 ± 0.49
Myelencephalon5.94 ± 0.54
Occipital Lobe6.07 ± 0.49
Parietal Lobe5.83 ± 0.57
Pontine Tegmentum6.08 ± 0.49
Striatum6.77 ± 0.38
Subthalamus5.51 ± 0.54
Temporal Lobe5.93 ± 0.4
Thalamus6.28 ± 0.55
White Matter5.97 ± 0.42
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Ptprz1CBCerebellum22.73
93.48
Ptprz1CTXCerebral cortex15.45
10.97
Ptprz1HIPHippocampal region15.72
14.29
Ptprz1HPFHippocampal formation16.59
13.72
Ptprz1HYHypothalamus13.23
8.97
Ptprz1LSXLateral septal complex20.38
14.9
Ptprz1MBMidbrain8.96
6.51
Ptprz1MYMedulla6.73
5.56
Ptprz1OLFOlfactory bulb45.88
32.78
Ptprz1PPons6.91
4.73
Ptprz1PALPallidum16.94
11.74
Ptprz1RHPRetrohippocampal region18.32
13.19
Ptprz1sAMYStriatum-like amygdalar nuclei21.57
15.11
Ptprz1STRStriatum15.71
11.63
Ptprz1STRdStriatum dorsal region12.6
9.91
Ptprz1STRvStriatum ventral region20.64
13.42
Ptprz1THThalamus7.83
5.37
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00072346 9 52 60 KYPTCNSPK Peptide Atlas
PTPRZ_HUMAN_2 5 2 6 RILKR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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