AutismKB 2.0

Annotation Detail for PTBP2


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Basic Information Top
Gene Symbol:PTBP2 ( FLJ34897,PTB,PTBLP,brPTB,nPTB,nPTB5,nPTB6,nPTB7,nPTB8 )
Gene Full Name: polypyrimidine tract binding protein 2
Band: 1p21.3
Quick LinksEntrez ID:58155; OMIM: 608449; Uniprot ID:PTBP2_HUMAN; ENSEMBL ID: ENSG00000117569; HGNC ID: 17662
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst3 / 6231948
fetus85 / 564012150
neonate2 / 3109764
infant1 / 2362042
juvenile2 / 5555635
adult52 / 193912126
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor2 / 17290115
gastrointestinal tumor0 / 1193690 
germ cell tumor19 / 26384572
glioma0 / 1068830 
head and neck tumor6 / 13630244
kidney tumor4 / 6895958
leukemia7 / 9584273
liver tumor2 / 9635920
lung tumor1 / 1031279
lymphoma1 / 7175513
non-neoplasia5 / 9725051
normal183 / 336030754
ovarian tumor3 / 7668239
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS2 / 12568015
prostate cancer0 / 1026800 
retinoblastoma2 / 4635643
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor2 / 9025722
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland0 / 331970 
ascites0 / 400150 
bladder1 / 2975733
blood1 / 1234788
bone0 / 716550 
bone marrow1 / 4880120
brain134 / 1100989121
cervix1 / 4817120
connective tissue1 / 1492556
ear0 / 162120 
embryonic tissue7 / 21572232
esophagus2 / 2020998
eye3 / 21105414
heart0 / 896260 
intestine4 / 23447217
kidney8 / 21177737
larynx0 / 241450 
liver4 / 20774319
lung5 / 33697414
lymph0 / 442700 
lymph node8 / 9161087
mammary gland5 / 15327132
mouth4 / 6705259
muscle3 / 10771527
nerve2 / 15768126
ovary3 / 10205129
pancreas2 / 2148129
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate6 / 18934531
salivary gland0 / 201550 
skin4 / 21057418
spleen0 / 539520 
stomach0 / 966190 
testis60 / 330442181
thymus9 / 81131110
thyroid2 / 4747342
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord0 / 136800 
uterus6 / 23287825
vascular2 / 5178038
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 218683_at
Cell line Expression level Expression bar
721_B_lymphoblasts18.2
Adipocyte7.15
AdrenalCortex13.65
Adrenalgland10.35
Amygdala55.7
Appendix24.2
AtrioventricularNode14.15
BDCA4+_DentriticCells8.25
Bonemarrow11.65
BronchialEpithelialCells6.8
CD105+_Endothelial10.85
CD14+_Monocytes8.45
CD19+_BCells(neg._sel.)14
CD33+_Myeloid13.2
CD34+13.6
CD4+_Tcells10.75
CD56+_NKCells10.05
CD71+_EarlyErythroid6.45
CD8+_Tcells9.6
CardiacMyocytes14.8
Caudatenucleus11.65
Cerebellum10.25
CerebellumPeduncles17.35
CiliaryGanglion10.9
CingulateCortex28.8
Colorectaladenocarcinoma10.35
DorsalRootGanglion12.4
FetalThyroid13.6
Fetalbrain126
Fetalliver7.9
Fetallung10.8
GlobusPallidus10.35
Heart16.95
Hypothalamus43.7
Kidney10.75
Leukemia_chronicMyelogenousK-56211.35
Leukemia_promyelocytic-HL-6013.75
Leukemialymphoblastic(MOLT-4)21.3
Liver15.75
Lung8.15
Lymphnode10
Lymphoma_burkitts(Daudi)16.95
Lymphoma_burkitts(Raji)27.1
MedullaOblongata29.85
OccipitalLobe16.1
OlfactoryBulb11.75
Ovary10.65
Pancreas9.4
PancreaticIslet11.05
ParietalLobe15.8
Pituitary13.85
Placenta6.5
Pons12.9
PrefrontalCortex77
Prostate12.55
Salivarygland9.7
SkeletalMuscle17.05
Skin10.5
SmoothMuscle6.95
Spinalcord20
SubthalamicNucleus13.55
SuperiorCervicalGanglion26.85
TemporalLobe12.75
Testis12.35
TestisGermCell16.2
TestisIntersitial12.45
TestisLeydigCell25.25
TestisSeminiferousTubule18.35
Thalamus15.9
Thymus8.45
Thyroid17
Tongue13.4
Tonsil10.1
Trachea10
TrigeminalGanglion14.3
Uterus61.85
UterusCorpus12.75
WholeBlood9.05
Wholebrain21
colon40.95
pineal_day103.64
pineal_night104.94
retina23.05
small_intestine18.3
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_32_P174832
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.07 ± 0.78
Basal Forebrain3.21 ± 0.28
Basal Part of Pons3.62 ± 0.42
Cerebellar Cortex3.91 ± 0.6
Cerebellar Nuclei3.61 ± 0.41
Claustrum3.67 ± 0.73
Epithalamus3.39 ± 0.73
Frontal Lobe3.83 ± 0.55
Globus Pallidus3.71 ± 0.72
Hypothalamus4.12 ± 0.41
Insula3.93 ± 0.57
Limbic Lobe3.77 ± 0.59
Mesencephalon3.95 ± 0.73
Myelencephalon3.7 ± 0.65
Occipital Lobe3.33 ± 0.68
Parietal Lobe3.75 ± 0.64
Pontine Tegmentum3.76 ± 0.67
Striatum3.21 ± 0.68
Subthalamus3.86 ± 0.02
Temporal Lobe3.76 ± 0.63
Thalamus3.53 ± 0.61
White Matter4.79 ± 0.43
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Ptbp2CBCerebellum4.87
5.69
Ptbp2CTXCerebral cortex3.63
2.82
Ptbp2HIPHippocampal region7.41
7.96
Ptbp2HPFHippocampal formation5.17
5.09
Ptbp2HYHypothalamus1.99
1.49
Ptbp2LSXLateral septal complex0.85
0.67
Ptbp2MBMidbrain1.91
1.69
Ptbp2MYMedulla4.93
5.36
Ptbp2OLFOlfactory bulb5.03
5.3
Ptbp2PPons2.7
2.75
Ptbp2PALPallidum1.12
1
Ptbp2RHPRetrohippocampal region0.96
0.71
Ptbp2sAMYStriatum-like amygdalar nuclei0.39
0.27
Ptbp2STRStriatum0.69
0.69
Ptbp2STRdStriatum dorsal region0.8
0.87
Ptbp2STRvStriatum ventral region0.48
0.45
Ptbp2THThalamus3.66
3.02
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00427065 12 192 203 VTLDVLHQIFSK Peptide Atlas
PTBP2_HUMAN_1 14 1 14 MDGIVTEVAVGVKR PRIDE
PTBP2_HUMAN_84 8 84 91 VTNILMLK PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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