AutismKB 2.0

Annotation Detail for PYGB


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Basic Information Top
Gene Symbol:PYGB ( MGC9213 )
Gene Full Name: phosphorylase, glycogen; brain
Band: 20p11.21
Quick LinksEntrez ID:5834; OMIM: 138550; Uniprot ID:PYGB_HUMAN; ENSEMBL ID: ENSG00000100994; HGNC ID: 9723
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body10 / 70761141
blastocyst14 / 62319224
fetus30 / 56401253
neonate0 / 310970 
infant0 / 236200 
juvenile7 / 55556125
adult177 / 193912191
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor3 / 12794234
bladder carcinoma1 / 1747557
breast (mammary gland) tumor9 / 9417895
cervical tumor1 / 3436629
chondrosarcoma11 / 82823132
colorectal tumor72 / 114246630
esophageal tumor2 / 17290115
gastrointestinal tumor17 / 119369142
germ cell tumor7 / 26384526
glioma18 / 106883168
head and neck tumor8 / 13630258
kidney tumor5 / 6895972
leukemia3 / 9584231
liver tumor1 / 9635910
lung tumor21 / 103127203
lymphoma9 / 71755125
non-neoplasia6 / 9725061
normal145 / 336030743
ovarian tumor4 / 7668252
pancreatic tumor13 / 104616124
primitive neuroectodermal tumor of the CNS18 / 125680143
prostate cancer6 / 10268058
retinoblastoma2 / 4635643
skin tumor47 / 124949376
soft tissue/muscle tissue tumor7 / 12519155
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland3 / 3319790
ascites7 / 40015174
bladder1 / 2975733
blood4 / 12347832
bone7 / 7165597
bone marrow1 / 4880120
brain62 / 110098956
cervix4 / 4817183
connective tissue6 / 14925540
ear0 / 162120 
embryonic tissue30 / 215722139
esophagus2 / 2020998
eye24 / 211054113
heart0 / 896260 
intestine85 / 234472362
kidney5 / 21177723
larynx2 / 2414582
liver1 / 2077434
lung44 / 336974130
lymph3 / 4427067
lymph node0 / 916100 
mammary gland13 / 15327184
mouth3 / 6705244
muscle1 / 1077159
nerve4 / 15768253
ovary6 / 10205158
pancreas13 / 21481260
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta4 / 28082514
prostate12 / 18934563
salivary gland0 / 201550 
skin50 / 210574237
spleen1 / 5395218
stomach9 / 9661993
testis4 / 33044212
thymus0 / 811310 
thyroid4 / 4747384
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus9 / 23287838
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 201481_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts16.6
Adipocyte21.75
AdrenalCortex14.45
Adrenalgland12.05
Amygdala49.15
Appendix14.2
AtrioventricularNode10.3
BDCA4+_DentriticCells16.85
Bonemarrow13.75
BronchialEpithelialCells144.25
CD105+_Endothelial6.55
CD14+_Monocytes15.15
CD19+_BCells(neg._sel.)13.9
CD33+_Myeloid20.05
CD34+16.2
CD4+_Tcells15.95
CD56+_NKCells17
CD71+_EarlyErythroid11.7
CD8+_Tcells13.1
CardiacMyocytes24.15
Caudatenucleus18.3
Cerebellum35.1
CerebellumPeduncles29.75
CiliaryGanglion7.65
CingulateCortex22.75
Colorectaladenocarcinoma33.5
DorsalRootGanglion10.45
FetalThyroid13.8
Fetalbrain15.5
Fetalliver12
Fetallung11.75
GlobusPallidus10.15
Heart94.8
Hypothalamus36.6
Kidney11.5
Leukemia_chronicMyelogenousK-56212.4
Leukemia_promyelocytic-HL-6012.25
Leukemialymphoblastic(MOLT-4)10.9
Liver18.1
Lung39.2
Lymphnode11.95
Lymphoma_burkitts(Daudi)17.7
Lymphoma_burkitts(Raji)19.35
MedullaOblongata15.3
OccipitalLobe19.65
OlfactoryBulb10.8
Ovary9.2
Pancreas11.85
PancreaticIslet15.1
ParietalLobe15.4
Pituitary16.5
Placenta14.75
Pons13.6
PrefrontalCortex36.3
Prostate129.55
Salivarygland11.15
SkeletalMuscle15.5
Skin10.6
SmoothMuscle16.1
Spinalcord26.6
SubthalamicNucleus18.65
SuperiorCervicalGanglion15.55
TemporalLobe12.85
Testis16.35
TestisGermCell11.95
TestisIntersitial11.45
TestisLeydigCell13.9
TestisSeminiferousTubule12.05
Thalamus17.7
Thymus11.95
Thyroid80.1
Tongue13.5
Tonsil13.55
Trachea21.15
TrigeminalGanglion13.5
Uterus13.8
UterusCorpus12.35
WholeBlood15.55
Wholebrain54.85
colon42.35
pineal_day16.8
pineal_night16.7
retina18.95
small_intestine13.75
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P210849
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.44 ± 0.44
Basal Forebrain6.64 ± 0.41
Basal Part of Pons6.59 ± 0.2
Cerebellar Cortex6.83 ± 0.26
Cerebellar Nuclei6.36 ± 0.25
Claustrum6.13 ± 0.39
Epithalamus6.48 ± 0.41
Frontal Lobe6.56 ± 0.32
Globus Pallidus6.54 ± 0.27
Hypothalamus6.63 ± 0.37
Insula6.67 ± 0.2
Limbic Lobe6.55 ± 0.34
Mesencephalon6.41 ± 0.44
Myelencephalon6.49 ± 0.4
Occipital Lobe6.26 ± 0.4
Parietal Lobe6.52 ± 0.37
Pontine Tegmentum6.44 ± 0.51
Striatum5.88 ± 0.33
Subthalamus5.97 ± 0.69
Temporal Lobe6.63 ± 0.31
Thalamus6.5 ± 0.36
White Matter5.55 ± 0.32
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
PygbCBCerebellum32.58
83.26
PygbCTXCerebral cortex93.89
84.23
PygbHIPHippocampal region100
100
PygbHPFHippocampal formation100
100
PygbHYHypothalamus85.27
89.48
PygbLSXLateral septal complex71.7
72.98
PygbMBMidbrain84.49
100
PygbMYMedulla90.58
100
PygbOLFOlfactory bulb82.78
76.19
PygbPPons79.65
100
PygbPALPallidum72.83
85.47
PygbRHPRetrohippocampal region95.73
100
PygbsAMYStriatum-like amygdalar nuclei84.83
84.01
PygbSTRStriatum58.52
54.42
PygbSTRdStriatum dorsal region51.76
46.66
PygbSTRvStriatum ventral region54.4
48.02
PygbTHThalamus67.42
72.42
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00003405 15 411 425 HLDHVAALFPGDVDR Peptide Atlas
PYGB_HUMAN_1 10 1 10 AKPLTDSEKR PRIDE
PYGB_HUMAN_139 22 139 160 LAACFLDSMATLGLAAYGYGIR PRIDE
PYGB_HUMAN_17 12 17 28 GLAGLGDVAEVR PRIDE
PYGB_HUMAN_170 15 170 184 IVNGWQVEEADDWLR PRIDE
PYGB_HUMAN_192 14 192 205 ARPEYMLPVHFYGR PRIDE
PYGB_HUMAN_2 10 2 11 AKPLTDSEKR PRIDE
PYGB_HUMAN_20 9 20 28 GLGDVAEVR PRIDE
PYGB_HUMAN_248 22 248 269 APNDFKLQDFNVGDYIEAVLDR PRIDE
PYGB_HUMAN_248 30 248 277 APNDFKLQDFNVGDYIEAVLDRNLAENISR PRIDE
PYGB_HUMAN_254 16 254 269 LQDFNVGDYIEAVLDR PRIDE
PYGB_HUMAN_278 12 278 289 VLYPNDNFFEGK PRIDE
PYGB_HUMAN_278 15 278 292 VLYPNDNFFEGKELR PRIDE
PYGB_HUMAN_293 17 293 309 LKQEYFVVAATLQDIIR PRIDE
PYGB_HUMAN_293 18 293 310 LKQEYFVVAATLQDIIRR PRIDE
PYGB_HUMAN_333 19 333 351 VAIQLNDTHPALSIPELMR PRIDE
PYGB_HUMAN_352 18 352 369 ILVDVEKVDWDKAWEITK PRIDE
PYGB_HUMAN_371 24 371 394 TCAYTNHTVLPEALERWPVSMFEK PRIDE
PYGB_HUMAN_399 11 399 409 HLEIIYAINQR PRIDE
PYGB_HUMAN_410 15 410 424 HLDHVAALFPGDVDR PRIDE
PYGB_HUMAN_465 18 465 482 QSVFKDFYELEPEKFQNK PRIDE
PYGB_HUMAN_490 17 490 506 RWLLLCNPGLADTIVEK PRIDE
PYGB_HUMAN_491 16 491 506 WLLLCNPGLADTIVEK PRIDE
PYGB_HUMAN_50 11 50 60 DYFFALAHTVR PRIDE
PYGB_HUMAN_50 17 50 66 DYFFALAHTVRDHLVGR PRIDE
PYGB_HUMAN_507 13 507 519 IGEEFLTDLSQLK PRIDE
PYGB_HUMAN_507 14 507 520 IGEEFLTDLSQLKK PRIDE
PYGB_HUMAN_521 12 521 532 LLPLVSDEVFIR PRIDE
PYGB_HUMAN_522 12 522 533 LLPLVSDEVFIR PRIDE
PYGB_HUMAN_576 14 576 589 QLLNCLHVVTLYNR PRIDE
PYGB_HUMAN_622 18 622 639 LVTSIGDVVNHDPVVGDR PRIDE
PYGB_HUMAN_622 20 622 641 LVTSIGDVVNHDPVVGDRLK PRIDE
PYGB_HUMAN_642 8 642 649 VIFLENYR PRIDE
PYGB_HUMAN_643 8 643 650 VIFLENYR PRIDE
PYGB_HUMAN_656 25 656 680 VIPAADLSQQISTAGTEASGTGNMK PRIDE
PYGB_HUMAN_715 9 715 723 VEDVEALDR PRIDE
PYGB_HUMAN_730 10 730 739 EYYDHLPELK PRIDE
PYGB_HUMAN_740 14 740 753 QAVDQISSGFFSPK PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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