AutismKB 2.0

Annotation Detail for MLL3


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Basic Information Top
Gene Symbol:MLL3 ( DKFZp686C08112,FLJ12625,FLJ38309,HALR,KIAA1506,KMT2C,MGC119851,MGC119852,MGC119853 )
Gene Full Name: myeloid/lymphoid or mixed-lineage leukemia 3
Band: 7q36.1
Quick LinksEntrez ID:58508; OMIM: 606833; Uniprot ID:MLL3_HUMAN; ENSEMBL ID: ENSG00000055609; HGNC ID:
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body6 / 7076184
blastocyst4 / 6231964
fetus64 / 564012113
neonate0 / 310970 
infant0 / 236200 
juvenile1 / 5555617
adult247 / 1939121127
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma1 / 1747557
breast (mammary gland) tumor9 / 9417895
cervical tumor0 / 343660 
chondrosarcoma3 / 8282336
colorectal tumor19 / 114246166
esophageal tumor0 / 172900 
gastrointestinal tumor11 / 11936992
germ cell tumor16 / 26384560
glioma9 / 10688384
head and neck tumor15 / 136302110
kidney tumor6 / 6895987
leukemia20 / 95842208
liver tumor2 / 9635920
lung tumor4 / 10312738
lymphoma4 / 7175555
non-neoplasia5 / 9725051
normal280 / 336030783
ovarian tumor7 / 7668291
pancreatic tumor5 / 10461647
primitive neuroectodermal tumor of the CNS4 / 12568031
prostate cancer2 / 10268019
retinoblastoma6 / 46356129
skin tumor7 / 12494956
soft tissue/muscle tissue tumor8 / 12519163
uterine tumor11 / 90257121
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland4 / 33197120
ascites1 / 4001524
bladder1 / 2975733
blood17 / 123478137
bone1 / 7165513
bone marrow6 / 48801122
brain72 / 110098965
cervix0 / 481710 
connective tissue5 / 14925533
ear0 / 162120 
embryonic tissue14 / 21572264
esophagus0 / 202090 
eye18 / 21105485
heart4 / 8962644
intestine23 / 23447298
kidney15 / 21177770
larynx7 / 24145289
liver12 / 20774357
lung26 / 33697477
lymph4 / 4427090
lymph node11 / 91610120
mammary gland28 / 153271182
mouth5 / 6705274
muscle2 / 10771518
nerve2 / 15768126
ovary7 / 10205168
pancreas16 / 21481274
parathyroid0 / 205390 
pharynx4 / 4132896
pituitary gland3 / 16585180
placenta43 / 280825153
prostate3 / 18934515
salivary gland0 / 201550 
skin12 / 21057456
spleen3 / 5395255
stomach15 / 96619155
testis16 / 33044248
thymus3 / 8113136
thyroid2 / 4747342
tonsil0 / 169990 
trachea3 / 5241357
umbilical cord0 / 136800 
uterus21 / 23287890
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: Primary tumors (U95A)
  • Affymatrix Probe ID: 1037_at
Cell line Expression level Expression bar
Pr1T4.723
Pr4T6.161
Pr5T5.382
Pr7T5.983
Pr1N6.104
Pr5N6.005
Pr6T7.067
Pr3N5.81
Pr3T6.221
Pr4N5.557
Pr2N5.32
Pr8N5.723
Pr8T6.496
Pr9N5.754
Pr10N6.266
Pr10T6.293
Pr9T5.566
Pr11T5.894
Pr12T5.858
Pr13AT6.369
Pr13BT6.223
Pr21T5.905
Pr22T6.122
Pr30T7.151
Pr23T6.766
Pr19T6.472
Pr26T6.315
Pr31T6.329
Pr16T6.777
Pr17T6.295
Pr24T6.174
Pr27T5.451
Pr29T5.105
OVR1025.99
HUOVR6.017
G26.953
G36.56
G57.706
G66.361
G85.773
G96.191
CO7T7.56
CO8T6.112
CO15T13.165
CO27T12.356
CO30T8.204
CO32T6.377
CO40T6.295
CO52N9.01
CO62N7.42
K15.959
K26.1
K35.225
K417.751
K14N7.686
K169.381
K177.575
K196.627
K2010.975
K226.242
CO9T9.402
CO20T23.735
CO24T46.24
CO36N8.304
K185.952
P1N5.79
P2N6.671
P5N6.972
P85.964
P115.686
P176.469
K216.827
K25N7.129
K28N8.634
CO42T6.876
P225.568
P13N5.997
LU11T6.363
LU16T6.793
LU7T6.122
LU8T6.198
LU12T6.4
LU13T27.433
LU5T6.881
LU6T15.31
LU14T6.535
LU17T6.734
LU50N5.689
LU52N6.577
LU18T6.473
LU55N7.091
LU3N7.166
P16B8.965
P237.536
OVR165.722
OVR195.747
OVR275.949
OVR285.977
OVR278E6.529
OVR26.063
OVR55.885
OVR86.583
OVR116.456
OVR126.375
OVR135.927
OVR226.588
OVR268.058
OVR107.83
OVR278S7.113
OVR16.235
LU19T6.169
LU20T6.357
LU24T7.768
LU25T6.505
LU31T7.656
LU34T6.99
LU39T5.799
CO14T6.823
CO21T7.614
CO23T6.825
CO41N6.189
LU40T7.392
LU41T5.891
LU44T6.551
LU46T6.485
LU49T6.449
L5N6.866
LU42T6.512
LU30T8.684
LU43T8.048
CO5T24.003
CO44T6.113
CO49T6.648
CO51T6.772
CO56T6.315
CO61T6.185
LU26T16.409
LU33T7.598
LU36T6.196
CO43T6.995
G187.083
G466.123
L11T52.364
L13N7.059
L30T7.259
L31T7.66
L32T7.867
L34T7.492
L35T9.574
B1N7.451
B5N6.391
B8T6.62
B10T6.608
B14T7.316
B16T6.385
B17T6.553
B1NR7.72
B20T9.106
B51NR7.415
B6T8.801
B15T15.763
B21T9.377
B29T6.68
B31T7.508
B32T7.777
B24T6.357
B46T6.603
B34T6.946
B36T6.653
B37T7.272
B38T6.63
B39T5.921
X1026.544
X116_026.543
G2805.774
X465.908
X585.876
G1866.847
G2966.379
L38T6.522
L31T.26.256
L26N6.948
N257ANTR6.74
N285BODY6.16
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_32_P209472
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala7.1 ± 0.22
Basal Forebrain7.39 ± 0.11
Basal Part of Pons6.83 ± 0.32
Cerebellar Cortex7.48 ± 0.19
Cerebellar Nuclei7.09 ± 0.29
Claustrum6.97 ± 0.41
Epithalamus7.17 ± 0.44
Frontal Lobe7.02 ± 0.32
Globus Pallidus7.72 ± 0.38
Hypothalamus7.1 ± 0.25
Insula7.03 ± 0.28
Limbic Lobe7.04 ± 0.35
Mesencephalon7.25 ± 0.36
Myelencephalon7.1 ± 0.38
Occipital Lobe7.15 ± 0.26
Parietal Lobe7.13 ± 0.4
Pontine Tegmentum7.14 ± 0.36
Striatum7.22 ± 0.49
Subthalamus7.16 ± 0.39
Temporal Lobe7.08 ± 0.26
Thalamus7.15 ± 0.37
White Matter8.17 ± 0.41
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Mll3CBCerebellum37.16
47.88
Mll3CTXCerebral cortex33.3
23.03
Mll3HIPHippocampal region35.02
41.25
Mll3HPFHippocampal formation34.78
34.17
Mll3HYHypothalamus9.65
7.99
Mll3LSXLateral septal complex16.3
12.72
Mll3MBMidbrain17.11
15.78
Mll3MYMedulla15.68
15
Mll3OLFOlfactory bulb34.63
26.35
Mll3PPons13.41
14.62
Mll3PALPallidum11.56
9.6
Mll3RHPRetrohippocampal region35.33
26.27
Mll3sAMYStriatum-like amygdalar nuclei23.49
16.35
Mll3STRStriatum17.53
12.78
Mll3STRdStriatum dorsal region18.32
13.68
Mll3STRvStriatum ventral region11.07
7.63
Mll3THThalamus16.42
13.53
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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