AutismKB 2.0

Annotation Detail for QDPR


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Basic Information Top
Gene Symbol:QDPR ( DHPR,FLJ42391,PKU2,SDR33C1 )
Gene Full Name: quinoid dihydropteridine reductase
Band: 4p15.32
Quick LinksEntrez ID:5860; OMIM: 612676; Uniprot ID:DHPR_HUMAN; ENSEMBL ID: ENSG00000151552; HGNC ID: 9752
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body4 / 7076156
blastocyst1 / 6231916
fetus25 / 56401244
neonate0 / 310970 
infant1 / 2362042
juvenile3 / 5555653
adult154 / 193912179
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor11 / 94178116
cervical tumor2 / 3436658
chondrosarcoma6 / 8282372
colorectal tumor4 / 11424635
esophageal tumor0 / 172900 
gastrointestinal tumor6 / 11936950
germ cell tumor6 / 26384522
glioma7 / 10688365
head and neck tumor12 / 13630288
kidney tumor5 / 6895972
leukemia6 / 9584262
liver tumor14 / 96359145
lung tumor0 / 1031270 
lymphoma3 / 7175541
non-neoplasia5 / 9725051
normal335 / 336030799
ovarian tumor6 / 7668278
pancreatic tumor23 / 104616219
primitive neuroectodermal tumor of the CNS46 / 125680366
prostate cancer2 / 10268019
retinoblastoma5 / 46356107
skin tumor37 / 124949296
soft tissue/muscle tissue tumor14 / 125191111
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland1 / 3319730
ascites3 / 4001574
bladder0 / 297570 
blood5 / 12347840
bone4 / 7165555
bone marrow1 / 4880120
brain407 / 1100989369
cervix7 / 48171145
connective tissue6 / 14925540
ear2 / 16212123
embryonic tissue12 / 21572255
esophagus0 / 202090 
eye24 / 211054113
heart10 / 89626111
intestine10 / 23447242
kidney14 / 21177766
larynx2 / 2414582
liver24 / 207743115
lung14 / 33697441
lymph0 / 442700 
lymph node2 / 9161021
mammary gland11 / 15327171
mouth0 / 670520 
muscle10 / 10771592
nerve3 / 15768190
ovary12 / 102051117
pancreas36 / 214812167
parathyroid3 / 20539146
pharynx1 / 4132824
pituitary gland0 / 165850 
placenta5 / 28082517
prostate8 / 18934542
salivary gland5 / 20155248
skin39 / 210574185
spleen0 / 539520 
stomach2 / 9661920
testis3 / 3304429
thymus0 / 811310 
thyroid5 / 47473105
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus13 / 23287855
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 209123_at
Cell line Expression level Expression bar
721_B_lymphoblasts72.3
Adipocyte232.2
AdrenalCortex61.65
Adrenalgland104
Amygdala2226.3
Appendix8.2
AtrioventricularNode5.6
BDCA4+_DentriticCells149.05
Bonemarrow10.4
BronchialEpithelialCells124.35
CD105+_Endothelial45.6
CD14+_Monocytes25.5
CD19+_BCells(neg._sel.)18.2
CD33+_Myeloid38.85
CD34+149.15
CD4+_Tcells12.7
CD56+_NKCells27.2
CD71+_EarlyErythroid7.65
CD8+_Tcells10.65
CardiacMyocytes29.2
Caudatenucleus1539.5
Cerebellum508.05
CerebellumPeduncles962.25
CiliaryGanglion7.5
CingulateCortex1375.85
Colorectaladenocarcinoma44.15
DorsalRootGanglion34.9
FetalThyroid15
Fetalbrain45.55
Fetalliver59.15
Fetallung34.65
GlobusPallidus495.1
Heart60.45
Hypothalamus4502.3
Kidney226.05
Leukemia_chronicMyelogenousK-5626.4
Leukemia_promyelocytic-HL-603.9
Leukemialymphoblastic(MOLT-4)45.5
Liver1355.7
Lung205.65
Lymphnode7.2
Lymphoma_burkitts(Daudi)7.7
Lymphoma_burkitts(Raji)6.7
MedullaOblongata2691.4
OccipitalLobe1097.2
OlfactoryBulb270.6
Ovary5.1
Pancreas24.8
PancreaticIslet114.05
ParietalLobe1871.9
Pituitary73.6
Placenta12.4
Pons814.7
PrefrontalCortex2008.35
Prostate202.8
Salivarygland17
SkeletalMuscle15.6
Skin7.7
SmoothMuscle17.05
Spinalcord1600.65
SubthalamicNucleus619.7
SuperiorCervicalGanglion8.45
TemporalLobe590.05
Testis32.95
TestisGermCell20.7
TestisIntersitial13.75
TestisLeydigCell8.2
TestisSeminiferousTubule8.35
Thalamus3463.95
Thymus22.65
Thyroid121.5
Tongue9.85
Tonsil8.55
Trachea22.9
TrigeminalGanglion6.2
Uterus27.15
UterusCorpus5.95
WholeBlood27.55
Wholebrain1838.1
colon40.7
pineal_day200.54
pineal_night233.36
retina865.3
small_intestine44.2
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_1205_PI416573500
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.74 ± 0.58
Basal Forebrain7.92 ± 0.36
Basal Part of Pons7.64 ± 0.59
Cerebellar Cortex7.33 ± 0.62
Cerebellar Nuclei8.65 ± 0.53
Claustrum6.67 ± 0.81
Epithalamus7.2 ± 1.24
Frontal Lobe7.81 ± 0.77
Globus Pallidus9.04 ± 0.32
Hypothalamus7.9 ± 0.35
Insula7.39 ± 0.54
Limbic Lobe6.95 ± 0.67
Mesencephalon7.74 ± 0.67
Myelencephalon7.69 ± 0.69
Occipital Lobe7.23 ± 0.85
Parietal Lobe7.46 ± 0.69
Pontine Tegmentum7.89 ± 0.59
Striatum8.13 ± 0.69
Subthalamus8.27 ± 0.33
Temporal Lobe7.46 ± 0.59
Thalamus8.14 ± 0.52
White Matter9.91 ± 0.59
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
QdprCBCerebellum49.67
50
QdprCTXCerebral cortex50
38.69
QdprHIPHippocampal region42.27
43.83
QdprHPFHippocampal formation47.48
41.73
QdprHYHypothalamus50
50
QdprLSXLateral septal complex50
47.88
QdprMBMidbrain50
50
QdprMYMedulla50
50
QdprOLFOlfactory bulb50
42.68
QdprPPons50
50
QdprPALPallidum50
50
QdprRHPRetrohippocampal region50
38.35
QdprsAMYStriatum-like amygdalar nuclei50
47.97
QdprSTRStriatum49.41
39.86
QdprSTRdStriatum dorsal region49.69
42.43
QdprSTRvStriatum ventral region39.76
27.31
QdprTHThalamus50
50
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
DHPR_HUMAN_138 16 138 153 AALDGTPGMIGYGMAK PRIDE
DHPR_HUMAN_167 24 167 190 NSGMPPGAAAIAVLPVTLDTPMNR PRIDE
DHPR_HUMAN_168 24 168 191 NSGMPPGAAAIAVLPVTLDTPMNR PRIDE
DHPR_HUMAN_2 10 2 11 AAAAAAGEAR PRIDE
DHPR_HUMAN_219 17 219 235 NRPSSGSLIQVVTTEGR PRIDE
PAp00002679 13 155 167 GAVHQLCQSLAGK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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