AutismKB 2.0

Annotation Detail for RAB27A


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Basic Information Top
Gene Symbol:RAB27A ( GS2,HsT18676,MGC117246,RAB27,RAM )
Gene Full Name: RAB27A, member RAS oncogene family
Band: 15q21.3
Quick LinksEntrez ID:5873; OMIM: 603868; Uniprot ID:RB27A_HUMAN; ENSEMBL ID: ENSG00000069974; HGNC ID: 9766
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body2 / 7076128
blastocyst2 / 6231932
fetus8 / 56401214
neonate1 / 3109732
infant0 / 236200 
juvenile0 / 555560 
adult59 / 193912130
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor6 / 9417863
cervical tumor1 / 3436629
chondrosarcoma5 / 8282360
colorectal tumor2 / 11424617
esophageal tumor0 / 172900 
gastrointestinal tumor3 / 11936925
germ cell tumor7 / 26384526
glioma1 / 1068839
head and neck tumor2 / 13630214
kidney tumor1 / 6895914
leukemia4 / 9584241
liver tumor0 / 963590 
lung tumor2 / 10312719
lymphoma1 / 7175513
non-neoplasia2 / 9725020
normal98 / 336030729
ovarian tumor0 / 766820 
pancreatic tumor3 / 10461628
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer4 / 10268038
retinoblastoma0 / 463560 
skin tumor20 / 124949160
soft tissue/muscle tissue tumor3 / 12519123
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland2 / 3319760
ascites1 / 4001524
bladder0 / 297570 
blood6 / 12347848
bone3 / 7165541
bone marrow4 / 4880181
brain5 / 11009894
cervix1 / 4817120
connective tissue8 / 14925553
ear0 / 162120 
embryonic tissue5 / 21572223
esophagus0 / 202090 
eye5 / 21105423
heart0 / 896260 
intestine10 / 23447242
kidney4 / 21177718
larynx0 / 241450 
liver6 / 20774328
lung6 / 33697417
lymph1 / 4427022
lymph node9 / 9161098
mammary gland9 / 15327158
mouth1 / 6705214
muscle2 / 10771518
nerve0 / 157680 
ovary0 / 1020510 
pancreas5 / 21481223
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland1 / 1658560
placenta10 / 28082535
prostate16 / 18934584
salivary gland5 / 20155248
skin28 / 210574132
spleen3 / 5395255
stomach4 / 9661941
testis1 / 3304423
thymus2 / 8113124
thyroid1 / 4747321
tonsil0 / 169990 
trachea2 / 5241338
umbilical cord0 / 136800 
uterus2 / 2328788
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 209515_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts93.25
Adipocyte5.9
AdrenalCortex7.25
Adrenalgland5.8
Amygdala5.85
Appendix8
AtrioventricularNode6.2
BDCA4+_DentriticCells24.2
Bonemarrow43.9
BronchialEpithelialCells6.7
CD105+_Endothelial9.55
CD14+_Monocytes352.3
CD19+_BCells(neg._sel.)27.35
CD33+_Myeloid511.9
CD34+46.8
CD4+_Tcells148.5
CD56+_NKCells476.35
CD71+_EarlyErythroid6.25
CD8+_Tcells314.05
CardiacMyocytes15.15
Caudatenucleus5.3
Cerebellum5.1
CerebellumPeduncles7.1
CiliaryGanglion4.6
CingulateCortex6.5
Colorectaladenocarcinoma5.85
DorsalRootGanglion5.6
FetalThyroid6.45
Fetalbrain5.9
Fetalliver5.4
Fetallung15.9
GlobusPallidus4.6
Heart8.35
Hypothalamus6
Kidney5.3
Leukemia_chronicMyelogenousK-56252.5
Leukemia_promyelocytic-HL-605.15
Leukemialymphoblastic(MOLT-4)5.45
Liver8.65
Lung7.8
Lymphnode13.8
Lymphoma_burkitts(Daudi)7.9
Lymphoma_burkitts(Raji)9
MedullaOblongata5.55
OccipitalLobe5.3
OlfactoryBulb5.3
Ovary4.7
Pancreas5.5
PancreaticIslet15.1
ParietalLobe6.95
Pituitary150.75
Placenta6.85
Pons5.9
PrefrontalCortex6.95
Prostate149.45
Salivarygland5.75
SkeletalMuscle8.45
Skin9.8
SmoothMuscle7.65
Spinalcord6.35
SubthalamicNucleus5.7
SuperiorCervicalGanglion9
TemporalLobe5.7
Testis5
TestisGermCell9.7
TestisIntersitial5.35
TestisLeydigCell6.45
TestisSeminiferousTubule5.25
Thalamus6.2
Thymus4.8
Thyroid24.25
Tongue6.95
Tonsil7.65
Trachea10.4
TrigeminalGanglion6.4
Uterus6.4
UterusCorpus6.4
WholeBlood452.2
Wholebrain4.6
colon46
pineal_day7.44
pineal_night7.28
retina23.625
small_intestine8.4
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P54373
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala3.65 ± 0.71
Basal Forebrain3.47 ± 0.67
Basal Part of Pons3.28 ± 0.72
Cerebellar Cortex4.21 ± 0.4
Cerebellar Nuclei3.85 ± 0.55
Claustrum3.61 ± 0.95
Epithalamus3.94 ± 0.75
Frontal Lobe3.4 ± 0.69
Globus Pallidus4 ± 0.59
Hypothalamus3.7 ± 0.62
Insula3.32 ± 0.78
Limbic Lobe3.26 ± 0.71
Mesencephalon3.76 ± 0.65
Myelencephalon3.53 ± 0.67
Occipital Lobe3.65 ± 0.74
Parietal Lobe3.54 ± 0.8
Pontine Tegmentum3.59 ± 0.78
Striatum3.62 ± 0.75
Subthalamus3.52 ± 0.96
Temporal Lobe3.35 ± 0.73
Thalamus3.46 ± 0.7
White Matter3.47 ± 1.05
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Rab27aCBCerebellum4.17
6.4
Rab27aCTXCerebral cortex6.8
5.65
Rab27aHIPHippocampal region31.76
37.4
Rab27aHPFHippocampal formation31.79
33.98
Rab27aHYHypothalamus24.21
21.19
Rab27aLSXLateral septal complex0.79
0.7
Rab27aMBMidbrain4.21
5.12
Rab27aMYMedulla4.96
7.7
Rab27aOLFOlfactory bulb23.47
22.41
Rab27aPPons14.97
20.11
Rab27aPALPallidum10.08
10.21
Rab27aRHPRetrohippocampal region31.53
28.92
Rab27asAMYStriatum-like amygdalar nuclei40.09
32.39
Rab27aSTRStriatum8.13
6.66
Rab27aSTRdStriatum dorsal region1.2
0.88
Rab27aSTRvStriatum ventral region17.5
14.1
Rab27aTHThalamus4.89
3.81
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00038975 13 142 154 VVKEEEAIALAEK Peptide Atlas
RB27A_HUMAN_11 11 11 21 FLALGDSGVGK PRIDE
RB27A_HUMAN_37 10 37 46 FITTVGIDFR PRIDE
RB27A_HUMAN_67 13 67 79 IHLQLWDTAGQER PRIDE
RB27A_HUMAN_82 8 82 89 SLTTAFFR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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