AutismKB 2.0

Annotation Detail for RAF1


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Basic Information Top
Gene Symbol:RAF1 ( CRAF,NS5,Raf-1,c-Raf )
Gene Full Name: v-raf-1 murine leukemia viral oncogene homolog 1
Band: 3p25.2
Quick LinksEntrez ID:5894; OMIM: 164760; Uniprot ID:RAF1_HUMAN; ENSEMBL ID: ENSG00000132155; HGNC ID: 9829
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body7 / 7076198
blastocyst15 / 62319240
fetus123 / 564012218
neonate8 / 31097257
infant5 / 23620211
juvenile10 / 55556179
adult247 / 1939121127
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor2 / 12794156
bladder carcinoma0 / 174750 
breast (mammary gland) tumor9 / 9417895
cervical tumor6 / 34366174
chondrosarcoma18 / 82823217
colorectal tumor4 / 11424635
esophageal tumor2 / 17290115
gastrointestinal tumor18 / 119369150
germ cell tumor49 / 263845185
glioma9 / 10688384
head and neck tumor24 / 136302176
kidney tumor5 / 6895972
leukemia27 / 95842281
liver tumor12 / 96359124
lung tumor20 / 103127193
lymphoma6 / 7175583
non-neoplasia11 / 97250113
normal424 / 3360307126
ovarian tumor4 / 7668252
pancreatic tumor6 / 10461657
primitive neuroectodermal tumor of the CNS15 / 125680119
prostate cancer20 / 102680194
retinoblastoma4 / 4635686
skin tumor36 / 124949288
soft tissue/muscle tissue tumor8 / 12519163
uterine tumor4 / 9025744
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue2 / 13106152
adrenal gland3 / 3319790
ascites7 / 40015174
bladder0 / 297570 
blood27 / 123478218
bone12 / 71655167
bone marrow5 / 48801102
brain135 / 1100989122
cervix6 / 48171124
connective tissue17 / 149255113
ear4 / 16212246
embryonic tissue38 / 215722176
esophagus2 / 2020998
eye24 / 211054113
heart16 / 89626178
intestine18 / 23447276
kidney17 / 21177780
larynx4 / 24145165
liver17 / 20774381
lung65 / 336974192
lymph1 / 4427022
lymph node14 / 91610152
mammary gland15 / 15327197
mouth19 / 67052283
muscle9 / 10771583
nerve4 / 15768253
ovary7 / 10205168
pancreas21 / 21481297
parathyroid2 / 2053997
pharynx2 / 4132848
pituitary gland1 / 1658560
placenta35 / 280825124
prostate23 / 189345121
salivary gland0 / 201550 
skin55 / 210574261
spleen1 / 5395218
stomach8 / 9661982
testis55 / 330442166
thymus38 / 81131468
thyroid4 / 4747384
tonsil0 / 169990 
trachea14 / 52413267
umbilical cord1 / 1368073
uterus14 / 23287860
vascular4 / 5178077
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 201244_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts389.4
Adipocyte61.6
AdrenalCortex23.6
Adrenalgland45.8
Amygdala83.55
Appendix11.05
AtrioventricularNode27.1
BDCA4+_DentriticCells315.65
Bonemarrow106.55
BronchialEpithelialCells116.25
CD105+_Endothelial202.75
CD14+_Monocytes359.1
CD19+_BCells(neg._sel.)282.5
CD33+_Myeloid647.4
CD34+405.4
CD4+_Tcells360.6
CD56+_NKCells395.65
CD71+_EarlyErythroid172.05
CD8+_Tcells374.95
CardiacMyocytes61.7
Caudatenucleus60.3
Cerebellum78.7
CerebellumPeduncles85.45
CiliaryGanglion26.25
CingulateCortex72.9
Colorectaladenocarcinoma109.85
DorsalRootGanglion28.05
FetalThyroid250.3
Fetalbrain221.65
Fetalliver100.05
Fetallung197.2
GlobusPallidus11.2
Heart140.6
Hypothalamus87.35
Kidney71.75
Leukemia_chronicMyelogenousK-56244.3
Leukemia_promyelocytic-HL-60118.2
Leukemialymphoblastic(MOLT-4)206
Liver80.3
Lung127.4
Lymphnode115.65
Lymphoma_burkitts(Daudi)179.6
Lymphoma_burkitts(Raji)73.95
MedullaOblongata29.4
OccipitalLobe67.55
OlfactoryBulb61.1
Ovary45.6
Pancreas41.45
PancreaticIslet81.75
ParietalLobe33.4
Pituitary21.2
Placenta200.65
Pons17.9
PrefrontalCortex180.5
Prostate131.3
Salivarygland60.7
SkeletalMuscle36.95
Skin46.6
SmoothMuscle110.1
Spinalcord61.2
SubthalamicNucleus26.7
SuperiorCervicalGanglion27.6
TemporalLobe27.5
Testis80.5
TestisGermCell157.7
TestisIntersitial61.4
TestisLeydigCell23.75
TestisSeminiferousTubule44.9
Thalamus42.65
Thymus175.9
Thyroid184.85
Tongue75.45
Tonsil99.85
Trachea64.1
TrigeminalGanglion15.15
Uterus115.95
UterusCorpus31.65
WholeBlood892.7
Wholebrain65.85
colon88.65
pineal_day297.76
pineal_night331.44
retina258.825
small_intestine147.6
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_12786_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala3.87 ± 0.97
Basal Forebrain3.37 ± 0.31
Basal Part of Pons3.77 ± 0.48
Cerebellar Cortex3.98 ± 0.43
Cerebellar Nuclei3.57 ± 0.46
Claustrum3.68 ± 0.59
Epithalamus3.35 ± 0.66
Frontal Lobe3.53 ± 0.71
Globus Pallidus3.62 ± 0.59
Hypothalamus3.13 ± 0.85
Insula3.42 ± 0.41
Limbic Lobe3.68 ± 0.57
Mesencephalon3.61 ± 0.6
Myelencephalon3.51 ± 0.68
Occipital Lobe3.52 ± 0.62
Parietal Lobe3.56 ± 0.59
Pontine Tegmentum3.49 ± 0.68
Striatum3.5 ± 0.63
Subthalamus3.3 ± 0.29
Temporal Lobe3.54 ± 0.64
Thalamus3.59 ± 0.56
White Matter3.87 ± 0.18
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Raf1CBCerebellum15.59
17.95
Raf1CTXCerebral cortex2.17
1.37
Raf1HIPHippocampal region19.86
8.92
Raf1HPFHippocampal formation13.97
6.11
Raf1HYHypothalamus2.01
1.15
Raf1LSXLateral septal complex1.03
0.58
Raf1MBMidbrain3.28
2.56
Raf1MYMedulla8.1
7.1
Raf1OLFOlfactory bulb15.17
9.7
Raf1PPons8.98
7.4
Raf1PALPallidum1.92
1.37
Raf1RHPRetrohippocampal region4.36
2.36
Raf1sAMYStriatum-like amygdalar nuclei0.86
0.49
Raf1STRStriatum1.08
0.53
Raf1STRdStriatum dorsal region0.59
0.32
Raf1STRvStriatum ventral region3.46
1.39
Raf1THThalamus4.59
2.64
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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