AutismKB 2.0

Annotation Detail for RALA


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Basic Information Top
Gene Symbol:RALA ( MGC48949,RAL )
Gene Full Name: v-ral simian leukemia viral oncogene homolog A (ras related)
Band: 7p14.1
Quick LinksEntrez ID:5898; OMIM: 179550; Uniprot ID:RALA_HUMAN; ENSEMBL ID: ENSG00000006451; HGNC ID: 9839
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body5 / 7076170
blastocyst4 / 6231964
fetus52 / 56401292
neonate7 / 31097225
infant0 / 236200 
juvenile3 / 5555653
adult94 / 193912148
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma1 / 1747557
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma6 / 8282372
colorectal tumor4 / 11424635
esophageal tumor0 / 172900 
gastrointestinal tumor6 / 11936950
germ cell tumor30 / 263845113
glioma2 / 10688318
head and neck tumor5 / 13630236
kidney tumor8 / 68959116
leukemia5 / 9584252
liver tumor3 / 9635931
lung tumor1 / 1031279
lymphoma2 / 7175527
non-neoplasia6 / 9725061
normal203 / 336030760
ovarian tumor3 / 7668239
pancreatic tumor4 / 10461638
primitive neuroectodermal tumor of the CNS8 / 12568063
prostate cancer0 / 1026800 
retinoblastoma6 / 46356129
skin tumor6 / 12494948
soft tissue/muscle tissue tumor7 / 12519155
uterine tumor3 / 9025733
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites1 / 4001524
bladder1 / 2975733
blood4 / 12347832
bone6 / 7165583
bone marrow4 / 4880181
brain59 / 110098953
cervix0 / 481710 
connective tissue8 / 14925553
ear0 / 162120 
embryonic tissue18 / 21572283
esophagus0 / 202090 
eye14 / 21105466
heart2 / 8962622
intestine20 / 23447285
kidney13 / 21177761
larynx1 / 2414541
liver4 / 20774319
lung16 / 33697447
lymph1 / 4427022
lymph node3 / 9161032
mammary gland4 / 15327126
mouth6 / 6705289
muscle4 / 10771537
nerve0 / 157680 
ovary2 / 10205119
pancreas10 / 21481246
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta16 / 28082556
prostate3 / 18934515
salivary gland0 / 201550 
skin13 / 21057461
spleen0 / 539520 
stomach7 / 9661972
testis27 / 33044281
thymus4 / 8113149
thyroid0 / 474730 
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord1 / 1368073
uterus9 / 23287838
vascular15 / 51780289
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 214435_x_at
Cell line Expression level Expression bar
721_B_lymphoblasts56.05
Adipocyte4.65
AdrenalCortex5.1
Adrenalgland3.8
Amygdala4.75
Appendix5.75
AtrioventricularNode3.75
BDCA4+_DentriticCells16.2
Bonemarrow4.4
BronchialEpithelialCells33.4
CD105+_Endothelial5.8
CD14+_Monocytes11.95
CD19+_BCells(neg._sel.)41.55
CD33+_Myeloid8.75
CD34+11.6
CD4+_Tcells6.65
CD56+_NKCells15.8
CD71+_EarlyErythroid4.2
CD8+_Tcells8.2
CardiacMyocytes74.2
Caudatenucleus3.9
Cerebellum3.1
CerebellumPeduncles5.05
CiliaryGanglion3.5
CingulateCortex4.55
Colorectaladenocarcinoma5.5
DorsalRootGanglion3.45
FetalThyroid4.4
Fetalbrain4.85
Fetalliver3.7
Fetallung4.4
GlobusPallidus3.2
Heart6.05
Hypothalamus4.8
Kidney3.6
Leukemia_chronicMyelogenousK-56214.2
Leukemia_promyelocytic-HL-6010.6
Leukemialymphoblastic(MOLT-4)3.5
Liver5.75
Lung5.55
Lymphnode3.5
Lymphoma_burkitts(Daudi)7.15
Lymphoma_burkitts(Raji)79.1
MedullaOblongata4
OccipitalLobe4
OlfactoryBulb3.8
Ovary2.95
Pancreas3.75
PancreaticIslet4.8
ParietalLobe4.7
Pituitary4.75
Placenta4.7
Pons4.45
PrefrontalCortex5.5
Prostate5.2
Salivarygland3.6
SkeletalMuscle7.85
Skin3.5
SmoothMuscle186.75
Spinalcord4.7
SubthalamicNucleus4.75
SuperiorCervicalGanglion5.35
TemporalLobe4.05
Testis3.9
TestisGermCell3.75
TestisIntersitial4.15
TestisLeydigCell4.45
TestisSeminiferousTubule3.9
Thalamus4.45
Thymus3.55
Thyroid5.65
Tongue19.85
Tonsil4.4
Trachea3.75
TrigeminalGanglion4.6
Uterus3.65
UterusCorpus4.05
WholeBlood5
Wholebrain3.75
colon46
pineal_day5.6
pineal_night5.46
retina5.35
small_intestine25.9
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_3672_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala8.23 ± 0.4
Basal Forebrain8.3 ± 0.16
Basal Part of Pons8.23 ± 0.24
Cerebellar Cortex8.05 ± 0.17
Cerebellar Nuclei8.38 ± 0.22
Claustrum8.15 ± 0.47
Epithalamus8.14 ± 0.46
Frontal Lobe8.42 ± 0.32
Globus Pallidus8.9 ± 0.21
Hypothalamus8.25 ± 0.35
Insula8.35 ± 0.38
Limbic Lobe8.45 ± 0.39
Mesencephalon8.41 ± 0.32
Myelencephalon8.36 ± 0.41
Occipital Lobe8.2 ± 0.4
Parietal Lobe8.29 ± 0.29
Pontine Tegmentum8.42 ± 0.33
Striatum8.54 ± 0.36
Subthalamus8.58 ± 0.16
Temporal Lobe8.38 ± 0.33
Thalamus8.44 ± 0.27
White Matter9.5 ± 0.16
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
RalaCBCerebellum1.26
1.5
RalaCTXCerebral cortex9.55
7.34
RalaHIPHippocampal region6.59
6.76
RalaHPFHippocampal formation5.29
4.96
RalaHYHypothalamus2.45
2.3
RalaLSXLateral septal complex0.2
0.14
RalaMBMidbrain1.52
1.86
RalaMYMedulla2.95
5.13
RalaOLFOlfactory bulb11.01
8.42
RalaPPons3.7
5.97
RalaPALPallidum8.21
8.18
RalaRHPRetrohippocampal region1.99
1.51
RalasAMYStriatum-like amygdalar nuclei3.79
2.93
RalaSTRStriatum3.65
2.74
RalaSTRdStriatum dorsal region2.38
1.8
RalaSTRvStriatum ventral region9.54
6.63
RalaTHThalamus4.12
3.35
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00000612 12 162 173 ANVDKVFFDLMR Peptide Atlas
RALA_HUMAN_113 15 113 127 VKEDENVPFLLVGNK PRIDE
RALA_HUMAN_136 10 136 145 QVSVEEAKNR PRIDE
RALA_HUMAN_145 14 145 158 AEQWNVNYVETSAK PRIDE
RALA_HUMAN_159 14 159 172 TRANVDKVFFDLMR PRIDE
RALA_HUMAN_16 11 16 26 VIMVGSGGVGK PRIDE
RALA_HUMAN_161 12 161 172 ANVDKVFFDLMR PRIDE
RALA_HUMAN_162 12 162 173 ANVDKVFFDLMR PRIDE
RALA_HUMAN_167 7 167 173 VFFDLMR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018