AutismKB 2.0

Annotation Detail for TMEM8A


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:TMEM8A ( M83,TMEM6,TMEM8 )
Gene Full Name: transmembrane protein 8A
Band: 16p13.3
Quick LinksEntrez ID:58986; OMIM: NA; Uniprot ID:TMM8A_HUMAN; ENSEMBL ID: ENSG00000129925; HGNC ID: 17205
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body3 / 7076142
blastocyst3 / 6231948
fetus12 / 56401221
neonate0 / 310970 
infant0 / 236200 
juvenile1 / 5555617
adult114 / 193912158
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma2 / 17475114
breast (mammary gland) tumor3 / 9417831
cervical tumor1 / 3436629
chondrosarcoma15 / 82823181
colorectal tumor13 / 114246113
esophageal tumor1 / 1729057
gastrointestinal tumor10 / 11936983
germ cell tumor14 / 26384553
glioma3 / 10688328
head and neck tumor1 / 1363027
kidney tumor5 / 6895972
leukemia2 / 9584220
liver tumor14 / 96359145
lung tumor9 / 10312787
lymphoma1 / 7175513
non-neoplasia5 / 9725051
normal137 / 336030740
ovarian tumor1 / 7668213
pancreatic tumor8 / 10461676
primitive neuroectodermal tumor of the CNS3 / 12568023
prostate cancer3 / 10268029
retinoblastoma2 / 4635643
skin tumor12 / 12494996
soft tissue/muscle tissue tumor7 / 12519155
uterine tumor9 / 9025799
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites3 / 4001574
bladder2 / 2975767
blood5 / 12347840
bone6 / 7165583
bone marrow0 / 488010 
brain13 / 110098911
cervix1 / 4817120
connective tissue2 / 14925513
ear0 / 162120 
embryonic tissue9 / 21572241
esophagus1 / 2020949
eye12 / 21105456
heart7 / 8962678
intestine22 / 23447293
kidney16 / 21177775
larynx0 / 241450 
liver14 / 20774367
lung34 / 336974100
lymph1 / 4427022
lymph node1 / 9161010
mammary gland9 / 15327158
mouth1 / 6705214
muscle3 / 10771527
nerve2 / 15768126
ovary2 / 10205119
pancreas13 / 21481260
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta21 / 28082574
prostate11 / 18934558
salivary gland0 / 201550 
skin14 / 21057466
spleen0 / 539520 
stomach7 / 9661972
testis14 / 33044242
thymus0 / 811310 
thyroid3 / 4747363
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord0 / 136800 
uterus18 / 23287877
vascular2 / 5178038
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 221882_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts35.2
Adipocyte15.4
AdrenalCortex18.75
Adrenalgland15.2
Amygdala18.95
Appendix17.6
AtrioventricularNode13.75
BDCA4+_DentriticCells47.2
Bonemarrow27.95
BronchialEpithelialCells17.8
CD105+_Endothelial18.4
CD14+_Monocytes38.4
CD19+_BCells(neg._sel.)21.8
CD33+_Myeloid25.35
CD34+19.35
CD4+_Tcells44.3
CD56+_NKCells29.45
CD71+_EarlyErythroid20.85
CD8+_Tcells52.45
CardiacMyocytes43.6
Caudatenucleus15.7
Cerebellum13.8
CerebellumPeduncles18.45
CiliaryGanglion11.4
CingulateCortex16.3
Colorectaladenocarcinoma27.85
DorsalRootGanglion12.5
FetalThyroid15.7
Fetalbrain16.9
Fetalliver16.65
Fetallung20.6
GlobusPallidus10.9
Heart67.6
Hypothalamus16.65
Kidney39.65
Leukemia_chronicMyelogenousK-56223.8
Leukemia_promyelocytic-HL-6014.1
Leukemialymphoblastic(MOLT-4)13.65
Liver35.1
Lung99.05
Lymphnode21.7
Lymphoma_burkitts(Daudi)21.65
Lymphoma_burkitts(Raji)26.65
MedullaOblongata15.1
OccipitalLobe15.35
OlfactoryBulb13.4
Ovary11.4
Pancreas35.85
PancreaticIslet31.6
ParietalLobe18.1
Pituitary21
Placenta170.45
Pons15.5
PrefrontalCortex20.45
Prostate86.15
Salivarygland13.3
SkeletalMuscle20.8
Skin12.6
SmoothMuscle27.3
Spinalcord18.15
SubthalamicNucleus13.9
SuperiorCervicalGanglion20.15
TemporalLobe14.9
Testis86.6
TestisGermCell53.8
TestisIntersitial20.3
TestisLeydigCell26.9
TestisSeminiferousTubule29.65
Thalamus16.5
Thymus20.1
Thyroid78.7
Tongue17.6
Tonsil16.55
Trachea21.15
TrigeminalGanglion17.4
Uterus12.95
UterusCorpus16.1
WholeBlood79.3
Wholebrain14.45
colon35.05
pineal_day19.8
pineal_night19.88
retina37.575
small_intestine17.6
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_2093_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.88 ± 0.69
Basal Forebrain5.52 ± 0.61
Basal Part of Pons5.34 ± 0.58
Cerebellar Cortex4.91 ± 0.35
Cerebellar Nuclei5.15 ± 0.52
Claustrum4.51 ± 0.83
Epithalamus5.72 ± 0.56
Frontal Lobe5.53 ± 0.54
Globus Pallidus5.33 ± 0.53
Hypothalamus5.12 ± 0.5
Insula5.65 ± 0.45
Limbic Lobe5.25 ± 0.67
Mesencephalon5.3 ± 0.62
Myelencephalon5.41 ± 0.65
Occipital Lobe4.88 ± 0.53
Parietal Lobe5.32 ± 0.53
Pontine Tegmentum5.32 ± 0.54
Striatum6.26 ± 0.52
Subthalamus5.52 ± 0.5
Temporal Lobe5.45 ± 0.44
Thalamus5.5 ± 0.54
White Matter5.44 ± 0.4
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Tmem8CBCerebellum3.9
4.89
Tmem8CTXCerebral cortex9.78
6.58
Tmem8HIPHippocampal region6.57
5.96
Tmem8HPFHippocampal formation4.81
4
Tmem8HYHypothalamus2.49
1.87
Tmem8LSXLateral septal complex0.03
0
Tmem8MBMidbrain9.03
8.84
Tmem8MYMedulla13.78
12.03
Tmem8OLFOlfactory bulb3.93
3.36
Tmem8PPons9.63
8.31
Tmem8PALPallidum7.31
5.43
Tmem8RHPRetrohippocampal region1.93
1.32
Tmem8sAMYStriatum-like amygdalar nuclei3.42
2.5
Tmem8STRStriatum1.62
1.25
Tmem8STRdStriatum dorsal region1.26
1.05
Tmem8STRvStriatum ventral region2.27
1.39
Tmem8THThalamus5.69
4.04
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00518164 16 40 55 SEVGLVSEHFSQAPQR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved