AutismKB 2.0

Annotation Detail for BCHE


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Basic Information Top
Gene Symbol:BCHE ( CHE1,E1 )
Gene Full Name: butyrylcholinesterase
Band: 3q26.1
Quick LinksEntrez ID:590; OMIM: 177400; Uniprot ID:CHLE_HUMAN; ENSEMBL ID: ENSG00000114200; HGNC ID: 983
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body2 / 7076128
blastocyst0 / 623190 
fetus18 / 56401231
neonate2 / 3109764
infant0 / 236200 
juvenile0 / 555560 
adult291 / 1939121150
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor4 / 12794312
bladder carcinoma0 / 174750 
breast (mammary gland) tumor2 / 9417821
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor4 / 26384515
glioma4 / 10688337
head and neck tumor11 / 13630280
kidney tumor3 / 6895943
leukemia0 / 958420 
liver tumor2 / 9635920
lung tumor0 / 1031270 
lymphoma1 / 7175513
non-neoplasia1 / 9725010
normal87 / 336030725
ovarian tumor1 / 7668213
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS8 / 12568063
prostate cancer6 / 10268058
retinoblastoma0 / 463560 
skin tumor5 / 12494940
soft tissue/muscle tissue tumor259 / 1251912068
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland4 / 33197120
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone3 / 7165541
bone marrow0 / 488010 
brain61 / 110098955
cervix0 / 481710 
connective tissue256 / 1492551715
ear1 / 1621261
embryonic tissue5 / 21572223
esophagus0 / 202090 
eye1 / 2110544
heart3 / 8962633
intestine5 / 23447221
kidney3 / 21177714
larynx0 / 241450 
liver10 / 20774348
lung2 / 3369745
lymph1 / 4427022
lymph node0 / 916100 
mammary gland3 / 15327119
mouth0 / 670520 
muscle3 / 10771527
nerve1 / 1576863
ovary0 / 1020510 
pancreas1 / 2148124
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate6 / 18934531
salivary gland0 / 201550 
skin5 / 21057423
spleen2 / 5395237
stomach1 / 9661910
testis3 / 3304429
thymus0 / 811310 
thyroid11 / 47473231
tonsil0 / 169990 
trachea2 / 5241338
umbilical cord2 / 13680146
uterus24 / 232878103
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 205433_at
Cell line Expression level Expression bar
721_B_lymphoblasts108.85
Adipocyte6.75
AdrenalCortex8.05
Adrenalgland6.2
Amygdala11.2
Appendix11.15
AtrioventricularNode6.6
BDCA4+_DentriticCells7.05
Bonemarrow7.6
BronchialEpithelialCells6.65
CD105+_Endothelial6.85
CD14+_Monocytes7.35
CD19+_BCells(neg._sel.)7.1
CD33+_Myeloid8.45
CD34+8.35
CD4+_Tcells7.05
CD56+_NKCells7.65
CD71+_EarlyErythroid6.6
CD8+_Tcells6.25
CardiacMyocytes12.55
Caudatenucleus6.25
Cerebellum5.7
CerebellumPeduncles8.2
CiliaryGanglion6.15
CingulateCortex7.3
Colorectaladenocarcinoma6.95
DorsalRootGanglion5.65
FetalThyroid6.8
Fetalbrain7.65
Fetalliver131.35
Fetallung31.45
GlobusPallidus5.5
Heart11.05
Hypothalamus9.45
Kidney6.25
Leukemia_chronicMyelogenousK-5626.2
Leukemia_promyelocytic-HL-606.1
Leukemialymphoblastic(MOLT-4)5.4
Liver21.05
Lung7.5
Lymphnode5.6
Lymphoma_burkitts(Daudi)9.05
Lymphoma_burkitts(Raji)303
MedullaOblongata6.25
OccipitalLobe7.35
OlfactoryBulb5.4
Ovary4.85
Pancreas5.7
PancreaticIslet7.45
ParietalLobe7.65
Pituitary7.95
Placenta6.8
Pons6.9
PrefrontalCortex8.45
Prostate7.8
Salivarygland5.75
SkeletalMuscle9.8
Skin6.45
SmoothMuscle7.75
Spinalcord7.35
SubthalamicNucleus6.5
SuperiorCervicalGanglion10.05
TemporalLobe6.45
Testis5.9
TestisGermCell5.45
TestisIntersitial6.9
TestisLeydigCell7.15
TestisSeminiferousTubule5.9
Thalamus8
Thymus5.2
Thyroid8.2
Tongue7.5
Tonsil6.75
Trachea5.75
TrigeminalGanglion8.1
Uterus106.8
UterusCorpus6.95
WholeBlood7.4
Wholebrain5.6
colon28.3
pineal_day8.84
pineal_night8.56
retina8.4
small_intestine7.5
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_15179_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.31 ± 0.44
Basal Forebrain6.64 ± 0.26
Basal Part of Pons5.67 ± 0.26
Cerebellar Cortex6.03 ± 0.39
Cerebellar Nuclei6.8 ± 0.4
Claustrum5.66 ± 0.62
Epithalamus6.3 ± 0.49
Frontal Lobe6.16 ± 0.55
Globus Pallidus7.35 ± 0.35
Hypothalamus6.3 ± 0.24
Insula6.05 ± 0.4
Limbic Lobe6.1 ± 0.56
Mesencephalon6.25 ± 0.48
Myelencephalon6.33 ± 0.58
Occipital Lobe5.99 ± 0.53
Parietal Lobe6.04 ± 0.48
Pontine Tegmentum6.54 ± 0.48
Striatum7.04 ± 0.5
Subthalamus5.84 ± 0.26
Temporal Lobe6.18 ± 0.48
Thalamus6.9 ± 0.57
White Matter8.14 ± 0.69
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
BcheCBCerebellum1.17
1.43
BcheCTXCerebral cortex1.06
0.92
BcheHIPHippocampal region0.7
0.6
BcheHPFHippocampal formation1.31
1.04
BcheHYHypothalamus0.59
0.39
BcheLSXLateral septal complex0.3
0.24
BcheMBMidbrain1.04
1.27
BcheMYMedulla2.95
3.46
BcheOLFOlfactory bulb2.14
2.46
BchePPons2.83
3.47
BchePALPallidum0.48
0.48
BcheRHPRetrohippocampal region2.84
2.02
BchesAMYStriatum-like amygdalar nuclei0.36
0.29
BcheSTRStriatum0.62
0.54
BcheSTRdStriatum dorsal region0.7
0.52
BcheSTRvStriatum ventral region0.69
0.66
BcheTHThalamus0.49
0.41
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
CHLE_HUMAN_1 11 1 11 MHSKVTIICIR PRIDE
PAp00024117 21 248 268 AILQSGSFNAPWAVTSLYEAR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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