AutismKB 2.0

Annotation Detail for RALGDS


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Basic Information Top
Gene Symbol:RALGDS ( FLJ20922,RGDS,RGF,RalGEF )
Gene Full Name: ral guanine nucleotide dissociation stimulator
Band: 9q34.13-q34.2
Quick LinksEntrez ID:5900; OMIM: 601619; Uniprot ID:GNDS_HUMAN; ENSEMBL ID: ENSG00000160271; HGNC ID: 9842
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body8 / 70761113
blastocyst2 / 6231932
fetus33 / 56401258
neonate1 / 3109732
infant0 / 236200 
juvenile3 / 5555653
adult138 / 193912171
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor3 / 12794234
bladder carcinoma0 / 174750 
breast (mammary gland) tumor7 / 9417874
cervical tumor1 / 3436629
chondrosarcoma4 / 8282348
colorectal tumor11 / 11424696
esophageal tumor0 / 172900 
gastrointestinal tumor11 / 11936992
germ cell tumor17 / 26384564
glioma18 / 106883168
head and neck tumor15 / 136302110
kidney tumor7 / 68959101
leukemia2 / 9584220
liver tumor1 / 9635910
lung tumor6 / 10312758
lymphoma4 / 7175555
non-neoplasia5 / 9725051
normal224 / 336030766
ovarian tumor3 / 7668239
pancreatic tumor15 / 104616143
primitive neuroectodermal tumor of the CNS11 / 12568087
prostate cancer4 / 10268038
retinoblastoma0 / 463560 
skin tumor2 / 12494916
soft tissue/muscle tissue tumor3 / 12519123
uterine tumor6 / 9025766
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue2 / 13106152
adrenal gland5 / 33197150
ascites8 / 40015199
bladder4 / 29757134
blood2 / 12347816
bone1 / 7165513
bone marrow3 / 4880161
brain114 / 1100989103
cervix1 / 4817120
connective tissue8 / 14925553
ear2 / 16212123
embryonic tissue16 / 21572274
esophagus0 / 202090 
eye11 / 21105452
heart3 / 8962633
intestine14 / 23447259
kidney10 / 21177747
larynx4 / 24145165
liver2 / 2077439
lung29 / 33697486
lymph2 / 4427045
lymph node5 / 9161054
mammary gland10 / 15327165
mouth6 / 6705289
muscle5 / 10771546
nerve4 / 15768253
ovary5 / 10205148
pancreas21 / 21481297
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland4 / 16585241
placenta24 / 28082585
prostate6 / 18934531
salivary gland1 / 2015549
skin5 / 21057423
spleen1 / 5395218
stomach6 / 9661962
testis7 / 33044221
thymus4 / 8113149
thyroid6 / 47473126
tonsil5 / 16999294
trachea5 / 5241395
umbilical cord1 / 1368073
uterus10 / 23287842
vascular3 / 5178057
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 209050_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts91.15
Adipocyte27.2
AdrenalCortex84.65
Adrenalgland121.75
Amygdala182.4
Appendix46.65
AtrioventricularNode50.3
BDCA4+_DentriticCells98.75
Bonemarrow55.75
BronchialEpithelialCells26.3
CD105+_Endothelial64.1
CD14+_Monocytes47.35
CD19+_BCells(neg._sel.)76.05
CD33+_Myeloid61.7
CD34+79.6
CD4+_Tcells252.65
CD56+_NKCells312.55
CD71+_EarlyErythroid236.25
CD8+_Tcells255.75
CardiacMyocytes39.4
Caudatenucleus176
Cerebellum167.95
CerebellumPeduncles289.65
CiliaryGanglion89.1
CingulateCortex167.8
Colorectaladenocarcinoma31.15
DorsalRootGanglion32.65
FetalThyroid70.1
Fetalbrain529.9
Fetalliver24.15
Fetallung99.85
GlobusPallidus84.55
Heart70.9
Hypothalamus159.35
Kidney35.1
Leukemia_chronicMyelogenousK-56274.9
Leukemia_promyelocytic-HL-6027.7
Leukemialymphoblastic(MOLT-4)44.05
Liver33.5
Lung192.25
Lymphnode202.4
Lymphoma_burkitts(Daudi)36.6
Lymphoma_burkitts(Raji)28.9
MedullaOblongata144.4
OccipitalLobe127.55
OlfactoryBulb45.55
Ovary26.5
Pancreas55.1
PancreaticIslet118.55
ParietalLobe150.9
Pituitary212.9
Placenta73.15
Pons92.5
PrefrontalCortex422.4
Prostate136.7
Salivarygland33.85
SkeletalMuscle37.7
Skin63.9
SmoothMuscle31.5
Spinalcord322.2
SubthalamicNucleus173.05
SuperiorCervicalGanglion62.65
TemporalLobe87.6
Testis29.15
TestisGermCell17.3
TestisIntersitial27.1
TestisLeydigCell31.6
TestisSeminiferousTubule26.4
Thalamus203.8
Thymus92.35
Thyroid91.75
Tongue108.35
Tonsil71.35
Trachea93.2
TrigeminalGanglion47.6
Uterus39.7
UterusCorpus21.35
WholeBlood54.75
Wholebrain174
colon25.2
pineal_day85.86
pineal_night58.52
retina111.9
small_intestine25.25
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P135190
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.31 ± 0.55
Basal Forebrain4.3 ± 0.51
Basal Part of Pons4.01 ± 0.48
Cerebellar Cortex4.72 ± 0.44
Cerebellar Nuclei4.24 ± 0.69
Claustrum3.7 ± 0.72
Epithalamus4.25 ± 0.93
Frontal Lobe4.29 ± 0.61
Globus Pallidus4.52 ± 0.56
Hypothalamus4.07 ± 0.51
Insula4.2 ± 0.67
Limbic Lobe4.33 ± 0.59
Mesencephalon4.28 ± 0.64
Myelencephalon4.32 ± 0.68
Occipital Lobe4.3 ± 0.59
Parietal Lobe4.13 ± 0.6
Pontine Tegmentum4.34 ± 0.55
Striatum4.42 ± 0.54
Subthalamus3.83 ± 0.65
Temporal Lobe4.34 ± 0.55
Thalamus4.56 ± 0.43
White Matter5.97 ± 0.25
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
RalgdsCBCerebellum61.21
51.02
RalgdsCTXCerebral cortex100
70.84
RalgdsHIPHippocampal region72.99
94.63
RalgdsHPFHippocampal formation86.72
79.69
RalgdsHYHypothalamus100
53.51
RalgdsLSXLateral septal complex100
57.42
RalgdsMBMidbrain100
51.52
RalgdsMYMedulla100
52.03
RalgdsOLFOlfactory bulb100
63.45
RalgdsPPons100
52.69
RalgdsPALPallidum100
61.97
RalgdsRHPRetrohippocampal region100
62.86
RalgdssAMYStriatum-like amygdalar nuclei100
79.78
RalgdsSTRStriatum100
62.68
RalgdsSTRdStriatum dorsal region100
62.36
RalgdsSTRvStriatum ventral region100
61.81
RalgdsTHThalamus87.22
39.84
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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