AutismKB 2.0

Annotation Detail for RAN


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Basic Information Top
Gene Symbol:RAN ( ARA24,Gsp1,TC4 )
Gene Full Name: RAN, member RAS oncogene family
Band: 12q24.33
Quick LinksEntrez ID:5901; OMIM: 601179; Uniprot ID:RAN_HUMAN; ENSEMBL ID: ENSG00000132341; HGNC ID: 9846
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body48 / 70761678
blastocyst42 / 62319673
fetus195 / 564012345
neonate14 / 31097450
infant12 / 23620508
juvenile26 / 55556467
adult445 / 1939121229
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor7 / 12794547
bladder carcinoma12 / 17475686
breast (mammary gland) tumor37 / 94178392
cervical tumor16 / 34366465
chondrosarcoma16 / 82823193
colorectal tumor43 / 114246376
esophageal tumor2 / 17290115
gastrointestinal tumor31 / 119369259
germ cell tumor172 / 263845651
glioma18 / 106883168
head and neck tumor23 / 136302168
kidney tumor34 / 68959493
leukemia36 / 95842375
liver tumor82 / 96359850
lung tumor112 / 1031271086
lymphoma57 / 71755794
non-neoplasia7 / 9725071
normal1066 / 3360307317
ovarian tumor30 / 76682391
pancreatic tumor41 / 104616391
primitive neuroectodermal tumor of the CNS83 / 125680660
prostate cancer57 / 102680555
retinoblastoma32 / 46356690
skin tumor91 / 124949728
soft tissue/muscle tissue tumor58 / 125191463
uterine tumor24 / 90257265
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue7 / 13106534
adrenal gland12 / 33197361
ascites7 / 40015174
bladder18 / 29757604
blood45 / 123478364
bone27 / 71655376
bone marrow23 / 48801471
brain422 / 1100989383
cervix17 / 48171352
connective tissue14 / 14925593
ear2 / 16212123
embryonic tissue136 / 215722630
esophagus2 / 2020998
eye67 / 211054317
heart24 / 89626267
intestine66 / 234472281
kidney60 / 211777283
larynx0 / 241450 
liver115 / 207743553
lung159 / 336974471
lymph51 / 442701152
lymph node14 / 91610152
mammary gland45 / 153271293
mouth16 / 67052238
muscle22 / 107715204
nerve2 / 15768126
ovary41 / 102051401
pancreas75 / 214812349
parathyroid2 / 2053997
pharynx17 / 41328411
pituitary gland2 / 16585120
placenta72 / 280825256
prostate77 / 189345406
salivary gland25 / 201551240
skin124 / 210574588
spleen20 / 53952370
stomach41 / 96619424
testis98 / 330442296
thymus16 / 81131197
thyroid5 / 47473105
tonsil28 / 169991647
trachea4 / 5241376
umbilical cord7 / 13680511
uterus91 / 232878390
vascular27 / 51780521
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 200749_at
Cell line Expression level Expression bar
721_B_lymphoblasts370.8
Adipocyte57.7
AdrenalCortex47.9
Adrenalgland58.9
Amygdala445.65
Appendix17.25
AtrioventricularNode7.95
BDCA4+_DentriticCells82.4
Bonemarrow19.85
BronchialEpithelialCells286.05
CD105+_Endothelial68.6
CD14+_Monocytes60.9
CD19+_BCells(neg._sel.)79.9
CD33+_Myeloid86.5
CD34+123.9
CD4+_Tcells29.15
CD56+_NKCells98.9
CD71+_EarlyErythroid39.85
CD8+_Tcells31.25
CardiacMyocytes89.45
Caudatenucleus111.55
Cerebellum73.15
CerebellumPeduncles119.8
CiliaryGanglion23.45
CingulateCortex171.75
Colorectaladenocarcinoma62.15
DorsalRootGanglion36
FetalThyroid29.45
Fetalbrain152.7
Fetalliver61.85
Fetallung53.35
GlobusPallidus70.8
Heart13
Hypothalamus446.4
Kidney8.6
Leukemia_chronicMyelogenousK-56234.8
Leukemia_promyelocytic-HL-60112.65
Leukemialymphoblastic(MOLT-4)68.4
Liver8.55
Lung32.2
Lymphnode21.65
Lymphoma_burkitts(Daudi)129.9
Lymphoma_burkitts(Raji)67.45
MedullaOblongata130.25
OccipitalLobe251.5
OlfactoryBulb60.4
Ovary9.15
Pancreas64.8
PancreaticIslet61.7
ParietalLobe158.4
Pituitary134.1
Placenta55.45
Pons74
PrefrontalCortex386.5
Prostate53.35
Salivarygland10
SkeletalMuscle22.95
Skin12
SmoothMuscle74.45
Spinalcord102.75
SubthalamicNucleus89
SuperiorCervicalGanglion16.75
TemporalLobe123.95
Testis80.55
TestisGermCell137.55
TestisIntersitial27
TestisLeydigCell35.75
TestisSeminiferousTubule37.15
Thalamus131.35
Thymus27.9
Thyroid107.2
Tongue11.05
Tonsil14.65
Trachea22.25
TrigeminalGanglion59.5
Uterus65.9
UterusCorpus24.7
WholeBlood48
Wholebrain270.45
colon109.65
pineal_day247.44
pineal_night222.6
retina128.325
small_intestine170.85
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P47547
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala8.96 ± 0.43
Basal Forebrain8.84 ± 0.36
Basal Part of Pons8.97 ± 0.38
Cerebellar Cortex8.87 ± 0.33
Cerebellar Nuclei8.87 ± 0.39
Claustrum8.69 ± 0.56
Epithalamus9.04 ± 0.46
Frontal Lobe9.1 ± 0.38
Globus Pallidus8.44 ± 0.58
Hypothalamus9.54 ± 0.27
Insula9.19 ± 0.4
Limbic Lobe8.83 ± 0.61
Mesencephalon8.87 ± 0.46
Myelencephalon8.83 ± 0.54
Occipital Lobe8.41 ± 0.6
Parietal Lobe8.94 ± 0.41
Pontine Tegmentum8.98 ± 0.54
Striatum8.39 ± 0.53
Subthalamus9.12 ± 0.49
Temporal Lobe9.06 ± 0.38
Thalamus8.81 ± 0.33
White Matter8.04 ± 0.24
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
RanCBCerebellum91.34
100
RanCTXCerebral cortex100
100
RanHIPHippocampal region100
100
RanHPFHippocampal formation100
100
RanHYHypothalamus100
100
RanLSXLateral septal complex100
100
RanMBMidbrain100
100
RanMYMedulla100
100
RanOLFOlfactory bulb100
100
RanPPons100
100
RanPALPallidum100
100
RanRHPRetrohippocampal region100
100
RansAMYStriatum-like amygdalar nuclei100
100
RanSTRStriatum100
97.61
RanSTRdStriatum dorsal region100
89.87
RanSTRvStriatum ventral region100
100
RanTHThalamus100
100
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00004662 19 58 76 KYVATLGVEVHPLVFHTNR Peptide Atlas
RAN_HUMAN_0 0 0 0 FNVWDTAGQEK PRIDE
RAN_HUMAN_0 0 0 0 LVLVGDGGTGK PRIDE
RAN_HUMAN_0 0 0 0 NLQYYDISAK PRIDE
RAN_HUMAN_1 28 1 28 AAQGEPQVQFKLVLVGDGGTGKTTFVKR PRIDE
RAN_HUMAN_110 13 110 122 VCENIPIVLCGNK PRIDE
RAN_HUMAN_110 17 110 126 VCENIPIVLCGNKVDIK PRIDE
RAN_HUMAN_110 19 110 128 VCENIPIVLCGNKVDIKDR PRIDE
RAN_HUMAN_12 11 12 22 LVLVGDGGTGK PRIDE
RAN_HUMAN_12 16 12 27 LVLVGDGGTGKTTFVK PRIDE
RAN_HUMAN_12 17 12 28 LVLVGDGGTGKTTFVKR PRIDE
RAN_HUMAN_134 6 134 139 SIVFHR PRIDE
RAN_HUMAN_140 12 140 151 KKNLQYYDISAK PRIDE
RAN_HUMAN_141 11 141 151 KNLQYYDISAK PRIDE
RAN_HUMAN_142 10 142 151 NLQYYDISAK PRIDE
RAN_HUMAN_152 14 152 165 SNYNFEKPFLWLAR PRIDE
RAN_HUMAN_28 10 28 37 RHLTGEFEKK PRIDE
RAN_HUMAN_30 8 30 37 HLTGEFEK PRIDE
RAN_HUMAN_37 19 37 55 KYVATLGVEVHPLVFHTNR PRIDE
RAN_HUMAN_38 18 38 55 YVATLGVEVHPLVFHTNR PRIDE
RAN_HUMAN_38 22 38 59 YVATLGVEVHPLVFHTNRGPIK PRIDE
RAN_HUMAN_56 15 56 70 GPIKFNVWDTAGQEK PRIDE
RAN_HUMAN_60 11 60 70 FNVWDTAGQEK PRIDE
RAN_HUMAN_64 12 64 75 DTAGQEKFGGLR PRIDE
RAN_HUMAN_65 11 65 75 TAGQEKFGGLR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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