AutismKB 2.0

Annotation Detail for RAP1A


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Basic Information Top
Gene Symbol:RAP1A ( KREV-1,KREV1,RAP1,SMGP21 )
Gene Full Name: RAP1A, member of RAS oncogene family
Band: 1p13.2
Quick LinksEntrez ID:5906; OMIM: 179520; Uniprot ID:RAP1A_HUMAN; ENSEMBL ID: ENSG00000116473; HGNC ID: 9855
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body5 / 7076170
blastocyst1 / 6231916
fetus40 / 56401270
neonate2 / 3109764
infant0 / 236200 
juvenile4 / 5555671
adult118 / 193912160
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma0 / 174750 
breast (mammary gland) tumor4 / 9417842
cervical tumor4 / 34366116
chondrosarcoma11 / 82823132
colorectal tumor4 / 11424635
esophageal tumor0 / 172900 
gastrointestinal tumor2 / 11936916
germ cell tumor18 / 26384568
glioma4 / 10688337
head and neck tumor4 / 13630229
kidney tumor3 / 6895943
leukemia3 / 9584231
liver tumor3 / 9635931
lung tumor2 / 10312719
lymphoma5 / 7175569
non-neoplasia2 / 9725020
normal221 / 336030765
ovarian tumor3 / 7668239
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS1 / 1256807
prostate cancer4 / 10268038
retinoblastoma2 / 4635643
skin tumor7 / 12494956
soft tissue/muscle tissue tumor7 / 12519155
uterine tumor3 / 9025733
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland1 / 3319730
ascites1 / 4001524
bladder0 / 297570 
blood9 / 12347872
bone8 / 71655111
bone marrow1 / 4880120
brain32 / 110098929
cervix4 / 4817183
connective tissue10 / 14925566
ear3 / 16212185
embryonic tissue11 / 21572250
esophagus0 / 202090 
eye8 / 21105437
heart1 / 8962611
intestine9 / 23447238
kidney16 / 21177775
larynx0 / 241450 
liver13 / 20774362
lung26 / 33697477
lymph2 / 4427045
lymph node8 / 9161087
mammary gland5 / 15327132
mouth0 / 670520 
muscle4 / 10771537
nerve2 / 15768126
ovary3 / 10205129
pancreas15 / 21481269
parathyroid4 / 20539194
pharynx1 / 4132824
pituitary gland3 / 16585180
placenta31 / 280825110
prostate11 / 18934558
salivary gland1 / 2015549
skin11 / 21057452
spleen1 / 5395218
stomach1 / 9661910
testis14 / 33044242
thymus0 / 811310 
thyroid3 / 4747363
tonsil0 / 169990 
trachea2 / 5241338
umbilical cord2 / 13680146
uterus13 / 23287855
vascular12 / 51780231
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 202362_at
Cell line Expression level Expression bar
721_B_lymphoblasts582.4
Adipocyte95.45
AdrenalCortex36.45
Adrenalgland144.05
Amygdala226.45
Appendix121.8
AtrioventricularNode46.65
BDCA4+_DentriticCells710
Bonemarrow348.7
BronchialEpithelialCells231.45
CD105+_Endothelial702.3
CD14+_Monocytes521.15
CD19+_BCells(neg._sel.)353.9
CD33+_Myeloid1057.6
CD34+459.05
CD4+_Tcells365.4
CD56+_NKCells946.1
CD71+_EarlyErythroid560.9
CD8+_Tcells229.95
CardiacMyocytes92.65
Caudatenucleus101.6
Cerebellum59.45
CerebellumPeduncles34.4
CiliaryGanglion44.2
CingulateCortex62.75
Colorectaladenocarcinoma99.6
DorsalRootGanglion50.8
FetalThyroid70.65
Fetalbrain82.4
Fetalliver194.45
Fetallung154.75
GlobusPallidus36.3
Heart42.2
Hypothalamus149.05
Kidney67.45
Leukemia_chronicMyelogenousK-562145.75
Leukemia_promyelocytic-HL-60359.05
Leukemialymphoblastic(MOLT-4)87.4
Liver81.3
Lung226.2
Lymphnode324.5
Lymphoma_burkitts(Daudi)190.55
Lymphoma_burkitts(Raji)287.8
MedullaOblongata57.8
OccipitalLobe85.2
OlfactoryBulb94.6
Ovary73
Pancreas86.8
PancreaticIslet124.9
ParietalLobe45.8
Pituitary148.75
Placenta174.2
Pons36.75
PrefrontalCortex130.15
Prostate340.25
Salivarygland161.2
SkeletalMuscle43.65
Skin63.6
SmoothMuscle130.35
Spinalcord394.1
SubthalamicNucleus44.85
SuperiorCervicalGanglion81.55
TemporalLobe41.35
Testis47.85
TestisGermCell55.1
TestisIntersitial24.95
TestisLeydigCell34.75
TestisSeminiferousTubule39.2
Thalamus90.6
Thymus113.85
Thyroid381.75
Tongue73.15
Tonsil203.3
Trachea235.1
TrigeminalGanglion23.75
Uterus234.6
UterusCorpus24.45
WholeBlood1200.75
Wholebrain99.1
colon741.85
pineal_day101.68
pineal_night98.84
retina193.425
small_intestine582.1
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_15175_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.6 ± 0.52
Basal Forebrain7.05 ± 0.33
Basal Part of Pons7.05 ± 0.49
Cerebellar Cortex7.19 ± 0.24
Cerebellar Nuclei7.57 ± 0.41
Claustrum6.67 ± 0.49
Epithalamus7.11 ± 0.76
Frontal Lobe7.16 ± 0.43
Globus Pallidus8.04 ± 0.23
Hypothalamus7.23 ± 0.25
Insula6.96 ± 0.17
Limbic Lobe6.77 ± 0.33
Mesencephalon7.12 ± 0.46
Myelencephalon7.05 ± 0.46
Occipital Lobe6.86 ± 0.38
Parietal Lobe6.93 ± 0.41
Pontine Tegmentum7.16 ± 0.3
Striatum7.06 ± 0.42
Subthalamus7.14 ± 0.37
Temporal Lobe7.01 ± 0.3
Thalamus7.18 ± 0.38
White Matter8.62 ± 0.49
Mouse Brain ISH
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00000894 7 118 124 CDLEDER Peptide Atlas
RAP1A_HUMAN_0 0 0 0 INVNEIFYDLVR PRIDE
RAP1A_HUMAN_0 0 0 0 LVVLGSGGVGK PRIDE
RAP1A_HUMAN_0 0 0 0 SKINVNEIFYDLVR PRIDE
RAP1A_HUMAN_0 0 0 0 YDPTIEDSYR PRIDE
RAP1A_HUMAN_102 15 102 116 VKDTEDVPMILVGNK PRIDE
RAP1A_HUMAN_117 11 117 127 CDLEDERVVGK PRIDE
RAP1A_HUMAN_117 19 117 135 CDLEDERVVGKEQGQNLAR PRIDE
RAP1A_HUMAN_149 14 149 162 SKINVNEIFYDLVR PRIDE
RAP1A_HUMAN_151 12 151 162 INVNEIFYDLVR PRIDE
RAP1A_HUMAN_16 15 16 30 SALTVQFVQGIFVEK PRIDE
RAP1A_HUMAN_16 25 16 40 SALTVQFVQGIFVEKYDPTIEDSYR PRIDE
RAP1A_HUMAN_16 26 16 41 SALTVQFVQGIFVEKYDPTIEDSYRK PRIDE
RAP1A_HUMAN_31 10 31 40 YDPTIEDSYR PRIDE
RAP1A_HUMAN_31 11 31 41 YDPTIEDSYRK PRIDE
RAP1A_HUMAN_5 11 5 15 LVVLGSGGVGK PRIDE
RAP1A_HUMAN_73 24 73 96 NGQGFALVYSITAQSTFNDLQDLR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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