AutismKB 2.0

Annotation Detail for RAP1GDS1


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Basic Information Top
Gene Symbol:RAP1GDS1 ( GDS1,MGC118859,MGC118861,SmgGDS )
Gene Full Name: RAP1, GTP-GDP dissociation stimulator 1
Band: 4q23
Quick LinksEntrez ID:5910; OMIM: 179502; Uniprot ID:GDS1_HUMAN; ENSEMBL ID: ENSG00000138698; HGNC ID: 9859
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst1 / 6231916
fetus75 / 564012132
neonate6 / 31097192
infant3 / 23620127
juvenile1 / 5555617
adult101 / 193912152
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma1 / 1747557
breast (mammary gland) tumor5 / 9417853
cervical tumor1 / 3436629
chondrosarcoma10 / 82823120
colorectal tumor7 / 11424661
esophageal tumor0 / 172900 
gastrointestinal tumor8 / 11936967
germ cell tumor13 / 26384549
glioma7 / 10688365
head and neck tumor2 / 13630214
kidney tumor14 / 68959203
leukemia4 / 9584241
liver tumor5 / 9635951
lung tumor1 / 1031279
lymphoma4 / 7175555
non-neoplasia6 / 9725061
normal263 / 336030778
ovarian tumor1 / 7668213
pancreatic tumor3 / 10461628
primitive neuroectodermal tumor of the CNS7 / 12568055
prostate cancer3 / 10268029
retinoblastoma2 / 4635643
skin tumor6 / 12494948
soft tissue/muscle tissue tumor21 / 125191167
uterine tumor2 / 9025722
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites3 / 4001574
bladder2 / 2975767
blood2 / 12347816
bone8 / 71655111
bone marrow3 / 4880161
brain158 / 1100989143
cervix3 / 4817162
connective tissue23 / 149255154
ear2 / 16212123
embryonic tissue2 / 2157229
esophagus0 / 202090 
eye8 / 21105437
heart4 / 8962644
intestine14 / 23447259
kidney30 / 211777141
larynx0 / 241450 
liver7 / 20774333
lung10 / 33697429
lymph0 / 442700 
lymph node2 / 9161021
mammary gland6 / 15327139
mouth5 / 6705274
muscle6 / 10771555
nerve0 / 157680 
ovary1 / 1020519
pancreas3 / 21481213
parathyroid7 / 20539340
pharynx1 / 4132824
pituitary gland3 / 16585180
placenta3 / 28082510
prostate3 / 18934515
salivary gland0 / 201550 
skin20 / 21057494
spleen5 / 5395292
stomach5 / 9661951
testis13 / 33044239
thymus4 / 8113149
thyroid0 / 474730 
tonsil0 / 169990 
trachea7 / 52413133
umbilical cord0 / 136800 
uterus10 / 23287842
vascular5 / 5178096
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 217457_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts112.15
Adipocyte39.2
AdrenalCortex30.15
Adrenalgland30
Amygdala163.8
Appendix42.45
AtrioventricularNode32
BDCA4+_DentriticCells224.05
Bonemarrow45.55
BronchialEpithelialCells173.1
CD105+_Endothelial35.55
CD14+_Monocytes38.45
CD19+_BCells(neg._sel.)57.95
CD33+_Myeloid46.3
CD34+75.1
CD4+_Tcells48.95
CD56+_NKCells77.9
CD71+_EarlyErythroid24
CD8+_Tcells42
CardiacMyocytes82.3
Caudatenucleus69.7
Cerebellum32.45
CerebellumPeduncles50.75
CiliaryGanglion28.35
CingulateCortex77.25
Colorectaladenocarcinoma38.1
DorsalRootGanglion43.55
FetalThyroid26.55
Fetalbrain101.35
Fetalliver35.55
Fetallung28.5
GlobusPallidus32.85
Heart61.25
Hypothalamus165.15
Kidney29.15
Leukemia_chronicMyelogenousK-56234.25
Leukemia_promyelocytic-HL-6035.2
Leukemialymphoblastic(MOLT-4)104.6
Liver63.1
Lung31.6
Lymphnode31.2
Lymphoma_burkitts(Daudi)61.8
Lymphoma_burkitts(Raji)47.6
MedullaOblongata56.2
OccipitalLobe80.65
OlfactoryBulb63.6
Ovary27.75
Pancreas29.8
PancreaticIslet42.2
ParietalLobe88.05
Pituitary42.85
Placenta30.5
Pons41.3
PrefrontalCortex69.75
Prostate44.5
Salivarygland31.6
SkeletalMuscle64.6
Skin22.1
SmoothMuscle78.75
Spinalcord84.9
SubthalamicNucleus37.35
SuperiorCervicalGanglion49.05
TemporalLobe42.25
Testis45.1
TestisGermCell53.05
TestisIntersitial74.1
TestisLeydigCell67.55
TestisSeminiferousTubule34.05
Thalamus151.4
Thymus30.7
Thyroid43.35
Tongue33.6
Tonsil46.8
Trachea31.8
TrigeminalGanglion34.1
Uterus23.8
UterusCorpus40.3
WholeBlood41.7
Wholebrain67.45
colon44.7
pineal_day75.34
pineal_night77.02
retina60.425
small_intestine24.85
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P58207
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala8.09 ± 0.5
Basal Forebrain8.2 ± 0.22
Basal Part of Pons9.07 ± 0.15
Cerebellar Cortex8.41 ± 0.31
Cerebellar Nuclei8.66 ± 0.3
Claustrum8.11 ± 0.52
Epithalamus7.94 ± 0.65
Frontal Lobe8.67 ± 0.44
Globus Pallidus8.37 ± 0.37
Hypothalamus8.35 ± 0.5
Insula8.47 ± 0.36
Limbic Lobe8.41 ± 0.65
Mesencephalon8.48 ± 0.56
Myelencephalon8.45 ± 0.59
Occipital Lobe8.13 ± 0.68
Parietal Lobe8.48 ± 0.43
Pontine Tegmentum8.45 ± 0.43
Striatum7.98 ± 0.42
Subthalamus8.77 ± 0.43
Temporal Lobe8.65 ± 0.47
Thalamus8.81 ± 0.33
White Matter9.31 ± 0.17
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Rap1gds1CBCerebellum75.12
100
Rap1gds1CTXCerebral cortex100
100
Rap1gds1HIPHippocampal region100
100
Rap1gds1HPFHippocampal formation100
100
Rap1gds1HYHypothalamus100
100
Rap1gds1LSXLateral septal complex100
100
Rap1gds1MBMidbrain100
100
Rap1gds1MYMedulla100
100
Rap1gds1OLFOlfactory bulb100
100
Rap1gds1PPons100
100
Rap1gds1PALPallidum100
100
Rap1gds1RHPRetrohippocampal region100
100
Rap1gds1sAMYStriatum-like amygdalar nuclei100
100
Rap1gds1STRStriatum100
100
Rap1gds1STRdStriatum dorsal region100
100
Rap1gds1STRvStriatum ventral region100
100
Rap1gds1THThalamus100
100
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
GDS1_HUMAN_242 17 242 258 EMIFEVLAPLAENDAIK PRIDE
GDS1_HUMAN_413 9 413 421 SEMPPVQFK PRIDE
GDS1_HUMAN_458 11 458 468 DHAGVMGESNR PRIDE
PAp00003977 29 84 112 IPCVDAGLISPLVQLLNSKDQEVLLQTGR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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