Annotation Detail for BCL2
Basic Information Top
| Gene Symbol: | BCL2 ( Bcl-2 ) |
|---|---|
| Gene Full Name: | B-cell CLL/lymphoma 2 |
| Band: | 18q21.33 |
| Quick Links | Entrez ID:596; OMIM: 151430; Uniprot ID:BCL2_HUMAN; ENSEMBL ID: ENSG00000171791; HGNC ID: 990 |
| Relate to Another Database: | SFARIGene; denovo-db |
- Unigene ID: Hs.150749
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
 | |||
| embryoid body | 0 / 70761 | 0 | |
| blastocyst | 0 / 62319 | 0 | |
| fetus | 15 / 564012 | 26 |  |
| neonate | 0 / 31097 | 0 | |
| infant | 0 / 23620 | 0 | |
| juvenile | 1 / 55556 | 17 | |
| adult | 56 / 1939121 | 28 | |
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
| |||
| adrenal tumor | 0 / 12794 | 0 | |
| bladder carcinoma | 0 / 17475 | 0 | |
| breast (mammary gland) tumor | 3 / 94178 | 31 | |
| cervical tumor | 0 / 34366 | 0 | |
| chondrosarcoma | 2 / 82823 | 24 | |
| colorectal tumor | 1 / 114246 | 8 |  |
| esophageal tumor | 0 / 17290 | 0 | |
| gastrointestinal tumor | 1 / 119369 | 8 | |
| germ cell tumor | 17 / 263845 | 64 |  |
| glioma | 1 / 106883 | 9 | |
| head and neck tumor | 3 / 136302 | 22 | |
| kidney tumor | 1 / 68959 | 14 | |
| leukemia | 10 / 95842 | 104 | |
| liver tumor | 0 / 96359 | 0 | |
| lung tumor | 0 / 103127 | 0 | |
| lymphoma | 10 / 71755 | 139 | |
| non-neoplasia | 5 / 97250 | 51 | |
| normal | 87 / 3360307 | 25 | |
| ovarian tumor | 6 / 76682 | 78 | |
| pancreatic tumor | 0 / 104616 | 0 | |
| primitive neuroectodermal tumor of the CNS | 0 / 125680 | 0 | |
| prostate cancer | 1 / 102680 | 9 | |
| retinoblastoma | 2 / 46356 | 43 | |
| skin tumor | 3 / 124949 | 24 | |
| soft tissue/muscle tissue tumor | 2 / 125191 | 15 | |
| uterine tumor | 1 / 90257 | 11 | |
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
| |||
| adipose tissue | 0 / 13106 | 0 | |
| adrenal gland | 0 / 33197 | 0 | |
| ascites | 0 / 40015 | 0 | |
| bladder | 0 / 29757 | 0 | |
| blood | 7 / 123478 | 56 | |
| bone | 1 / 71655 | 13 | |
| bone marrow | 1 / 48801 | 20 | |
| brain | 16 / 1100989 | 14 | |
| cervix | 0 / 48171 | 0 | |
| connective tissue | 3 / 149255 | 20 | |
| ear | 0 / 16212 | 0 | |
| embryonic tissue | 1 / 215722 | 4 | |
| esophagus | 0 / 20209 | 0 | |
| eye | 3 / 211054 | 14 | |
| heart | 4 / 89626 | 44 | |
| intestine | 2 / 234472 | 8 | |
| kidney | 12 / 211777 | 56 | |
| larynx | 0 / 24145 | 0 | |
| liver | 0 / 207743 | 0 | |
| lung | 8 / 336974 | 23 | |
| lymph | 10 / 44270 | 225 |  |
| lymph node | 5 / 91610 | 54 | |
| mammary gland | 3 / 153271 | 19 | |
| mouth | 1 / 67052 | 14 | |
| muscle | 2 / 107715 | 18 | |
| nerve | 1 / 15768 | 63 | |
| ovary | 6 / 102051 | 58 | |
| pancreas | 0 / 214812 | 0 | |
| parathyroid | 2 / 20539 | 97 | |
| pharynx | 0 / 41328 | 0 | |
| pituitary gland | 1 / 16585 | 60 | |
| placenta | 16 / 280825 | 56 | |
| prostate | 4 / 189345 | 21 | |
| salivary gland | 0 / 20155 | 0 | |
| skin | 10 / 210574 | 47 | |
| spleen | 0 / 53952 | 0 | |
| stomach | 7 / 96619 | 72 | |
| testis | 5 / 330442 | 15 | |
| thymus | 1 / 81131 | 12 | |
| thyroid | 3 / 47473 | 63 | |
| tonsil | 0 / 16999 | 0 | |
| trachea | 0 / 52413 | 0 | |
| umbilical cord | 0 / 13680 | 0 | |
| uterus | 2 / 232878 | 8 | |
| vascular | 2 / 51780 | 38 | |
- Microarray Platform: GeneAtlas U133A, gcrma
- Affymatrix Probe ID: 207005_s_at
| Cell line | Expression level | Expression bar |
|---|---|---|
| ||
| 721_B_lymphoblasts | 8.1 | |
| Adipocyte | 5.55 | |
| AdrenalCortex | 6.25 | |
| Adrenalgland | 4.7 | |
| Amygdala | 5.15 | |
| Appendix | 5.55 | |
| AtrioventricularNode | 11.25 | |
| BDCA4+_DentriticCells | 6.4 | |
| Bonemarrow | 6.55 | |
| BronchialEpithelialCells | 5.2 | |
| CD105+_Endothelial | 9.3 | |
| CD14+_Monocytes | 6.3 | |
| CD19+_BCells(neg._sel.) | 21.2 | |
| CD33+_Myeloid | 7.3 | |
| CD34+ | 11.25 | |
| CD4+_Tcells | 6.6 | |
| CD56+_NKCells | 8.2 | |
| CD71+_EarlyErythroid | 9.95 | |
| CD8+_Tcells | 5.55 | |
| CardiacMyocytes | 6.9 | |
| Caudatenucleus | 4.9 | |
| Cerebellum | 4.45 | |
| CerebellumPeduncles | 12.7 | |
| CiliaryGanglion | 6.5 | |
| CingulateCortex | 9.9 | |
| Colorectaladenocarcinoma | 5.3 | |
| DorsalRootGanglion | 4.45 | |
| FetalThyroid | 5.4 | |
| Fetalbrain | 5.4 | |
| Fetalliver | 4.9 | |
| Fetallung | 4.05 | |
| GlobusPallidus | 7.85 | |
| Heart | 6.95 | |
| Hypothalamus | 6.05 | |
| Kidney | 4.7 | |
| Leukemia_chronicMyelogenousK-562 | 5.1 | |
| Leukemia_promyelocytic-HL-60 | 4.9 | |
| Leukemialymphoblastic(MOLT-4) | 4.5 | |
| Liver | 7.4 | |
| Lung | 5.9 | |
| Lymphnode | 4.7 | |
| Lymphoma_burkitts(Daudi) | 7.1 | |
| Lymphoma_burkitts(Raji) | 7.65 | |
| MedullaOblongata | 4.8 | |
| OccipitalLobe | 5.05 | |
| OlfactoryBulb | 4.4 | |
| Ovary | 4.05 | |
| Pancreas | 4.6 | |
| PancreaticIslet | 5.95 | |
| ParietalLobe | 5.8 | |
| Pituitary | 6.55 | |
| Placenta | 5.15 | |
| Pons | 5.35 | |
| PrefrontalCortex | 6.5 | |
| Prostate | 6.1 | |
| Salivarygland | 4.4 | |
| SkeletalMuscle | 9.2 | |
| Skin | 4.6 | |
| SmoothMuscle | 6.05 | |
| Spinalcord | 5.95 | |
| SubthalamicNucleus | 8 | |
| SuperiorCervicalGanglion | 6.3 | |
| TemporalLobe | 6.05 | |
| Testis | 4.55 | |
| TestisGermCell | 4.35 | |
| TestisIntersitial | 4.65 | |
| TestisLeydigCell | 5.5 | |
| TestisSeminiferousTubule | 7.55 | |
| Thalamus | 10.9 | |
| Thymus | 4.1 | |
| Thyroid | 6.15 | |
| Tongue | 5.45 | |
| Tonsil | 5.4 | |
| Trachea | 6.05 | |
| TrigeminalGanglion | 6.05 | |
| Uterus | 4.3 | |
| UterusCorpus | 4.9 | |
| WholeBlood | 5.7 | |
| Wholebrain | 4.2 | |
| colon | 5.25 | |
| pineal_day | 9.18 | |
| pineal_night | 7.34 | |
| retina | 6.625 | |
| small_intestine | 4.8 | |
- Probe name: CUST_110_PI416408490
- Donor H0351.2001
- Sex: Male Age: 24 years Race/Ethnicity: African American Handedness: Left
- Tissue Receipt Date: 7/29/2009 Serology: Pass Tissue pH :6.72 Additional Medical Information :History of asthma
- Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
- Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
| Tissue | Expression(mean ± stddev) | Expression Bar |
|---|---|---|
| Amygdala | 5.47 ± 0.45 | ![](../"images/bar_3.png"){kind=small}   |
| Basal Forebrain | 5.71 ± 0.25 | |
| Basal Part of Pons | 4 ± 0.49 | |
| Cerebellar Cortex | 4.5 ± 0.42 | |
| Cerebellar Nuclei | 4.39 ± 0.93 | |
| Claustrum | 4.33 ± 0.82 | |
| Epithalamus | 5.68 ± 0.19 | |
| Frontal Lobe | 4.94 ± 0.6 | |
| Globus Pallidus | 6.78 ± 0.5 | |
| Hypothalamus | 5.53 ± 0.37 | |
| Insula | 5.38 ± 0.45 | |
| Limbic Lobe | 4.86 ± 0.71 | |
| Mesencephalon | 5.49 ± 0.57 | |
| Myelencephalon | 5.32 ± 0.78 | |
| Occipital Lobe | 5.43 ± 0.56 | |
| Parietal Lobe | 5.2 ± 0.61 | |
| Pontine Tegmentum | 5.37 ± 0.52 | |
| Striatum | 5.78 ± 0.41 | |
| Subthalamus | 4.86 ± 0.73 | |
| Temporal Lobe | 5.26 ± 0.51 | |
| Thalamus | 5.64 ± 0.55 | |
| White Matter | 4.52 ± 0.3 | |
Mouse Brain ISH 
| Gene Symbol | Brain Structure ID | Brain Structure Name | Express Desity/Level (Meatured by ISH) | Express Bar |
|---|---|---|---|---|
| Bcl2 | CB | Cerebellum | 3.01 | |
| 3.56 | | |||
| Bcl2 | CTX | Cerebral cortex | 5.83 | |
| 4.31 | | |||
| Bcl2 | HIP | Hippocampal region | 2.19 | |
| 1.84 | | |||
| Bcl2 | HPF | Hippocampal formation | 2.08 | |
| 1.6 | | |||
| Bcl2 | HY | Hypothalamus | 3.11 | |
| 2.31 | | |||
| Bcl2 | LSX | Lateral septal complex | 0.98 | |
| 0.69 | | |||
| Bcl2 | MB | Midbrain | 6.03 | |
| 5.37 | | |||
| Bcl2 | MY | Medulla | 11.32 | |
| 11.96 | | |||
| Bcl2 | OLF | Olfactory bulb | 13.71 | |
| 11.53 | | |||
| Bcl2 | P | Pons | 9.76 | |
| 10.22 | | |||
| Bcl2 | PAL | Pallidum | 4.7 | |
| 3.91 | | |||
| Bcl2 | RHP | Retrohippocampal region | 1.75 | |
| 1.12 | | |||
| Bcl2 | sAMY | Striatum-like amygdalar nuclei | 6.28 | |
| 4.15 | | |||
| Bcl2 | STR | Striatum | 3.55 | |
| 2.39 | | |||
| Bcl2 | STRd | Striatum dorsal region | 3.36 | |
| 2.28 | | |||
| Bcl2 | STRv | Striatum ventral region | 3.68 | |
| 2.31 | | |||
| Bcl2 | TH | Thalamus | 7.67 | |
| 6.44 | |
| Peptide Name | Peptide Lengh | Peptide Start | Peptide End | Peptide Sequence | Source |
|---|---|---|---|---|---|
| BCL2_HUMAN_129 | 10 | 129 | 138 | FATVVEELFR | PRIDE |
| PAp00487312 | 30 | 69 | 98 | TSPLQTPAAPGAAAGPALSPVPPVVHLTLR | Peptide Atlas |