AutismKB 2.0

Annotation Detail for REST


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Basic Information Top
Gene Symbol:REST ( NRSF,XBR )
Gene Full Name: RE1-silencing transcription factor
Band: 4q12
Quick LinksEntrez ID:5978; OMIM: 600571; Uniprot ID:REST_HUMAN; ENSEMBL ID: ENSG00000084093; HGNC ID: 9966
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body5 / 7076170
blastocyst1 / 6231916
fetus18 / 56401231
neonate1 / 3109732
infant0 / 236200 
juvenile2 / 5555635
adult68 / 193912135
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma4 / 17475228
breast (mammary gland) tumor1 / 9417810
cervical tumor0 / 343660 
chondrosarcoma2 / 8282324
colorectal tumor1 / 1142468
esophageal tumor0 / 172900 
gastrointestinal tumor2 / 11936916
germ cell tumor14 / 26384553
glioma0 / 1068830 
head and neck tumor5 / 13630236
kidney tumor6 / 6895987
leukemia5 / 9584252
liver tumor3 / 9635931
lung tumor2 / 10312719
lymphoma1 / 7175513
non-neoplasia3 / 9725030
normal114 / 336030733
ovarian tumor5 / 7668265
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer1 / 1026809
retinoblastoma0 / 463560 
skin tumor1 / 1249498
soft tissue/muscle tissue tumor2 / 12519115
uterine tumor4 / 9025744
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder2 / 2975767
blood4 / 12347832
bone1 / 7165513
bone marrow1 / 4880120
brain6 / 11009895
cervix0 / 481710 
connective tissue4 / 14925526
ear0 / 162120 
embryonic tissue11 / 21572250
esophagus0 / 202090 
eye6 / 21105428
heart3 / 8962633
intestine2 / 2344728
kidney15 / 21177770
larynx1 / 2414541
liver10 / 20774348
lung12 / 33697435
lymph0 / 442700 
lymph node5 / 9161054
mammary gland7 / 15327145
mouth3 / 6705244
muscle3 / 10771527
nerve2 / 15768126
ovary5 / 10205148
pancreas1 / 2148124
parathyroid2 / 2053997
pharynx2 / 4132848
pituitary gland0 / 165850 
placenta9 / 28082532
prostate3 / 18934515
salivary gland0 / 201550 
skin4 / 21057418
spleen0 / 539520 
stomach2 / 9661920
testis8 / 33044224
thymus2 / 8113124
thyroid1 / 4747321
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord1 / 1368073
uterus8 / 23287834
vascular4 / 5178077
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 204535_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts16.35
Adipocyte12.35
AdrenalCortex16.4
Adrenalgland11.95
Amygdala9.55
Appendix17.45
AtrioventricularNode29.5
BDCA4+_DentriticCells17.4
Bonemarrow13.55
BronchialEpithelialCells12.1
CD105+_Endothelial21.1
CD14+_Monocytes15.05
CD19+_BCells(neg._sel.)14.95
CD33+_Myeloid21.9
CD34+29.25
CD4+_Tcells16.05
CD56+_NKCells22.2
CD71+_EarlyErythroid31.4
CD8+_Tcells13.55
CardiacMyocytes15.75
Caudatenucleus12.45
Cerebellum11.95
CerebellumPeduncles15.55
CiliaryGanglion17.6
CingulateCortex14.4
Colorectaladenocarcinoma11.3
DorsalRootGanglion30.35
FetalThyroid11.3
Fetalbrain13.45
Fetalliver13.65
Fetallung14.25
GlobusPallidus16.9
Heart15.05
Hypothalamus13.8
Kidney10.95
Leukemia_chronicMyelogenousK-56212.55
Leukemia_promyelocytic-HL-6013.65
Leukemialymphoblastic(MOLT-4)11.1
Liver16.4
Lung13.7
Lymphnode11.9
Lymphoma_burkitts(Daudi)17.6
Lymphoma_burkitts(Raji)19.1
MedullaOblongata12.7
OccipitalLobe10.15
OlfactoryBulb20.75
Ovary14.85
Pancreas11.6
PancreaticIslet15.65
ParietalLobe13.4
Pituitary18.05
Placenta14.5
Pons23.95
PrefrontalCortex14
Prostate12.95
Salivarygland14.6
SkeletalMuscle17.45
Skin21.25
SmoothMuscle12.35
Spinalcord15.9
SubthalamicNucleus13.9
SuperiorCervicalGanglion26.35
TemporalLobe12.9
Testis10.7
TestisGermCell11.8
TestisIntersitial12.7
TestisLeydigCell16.05
TestisSeminiferousTubule16
Thalamus13.5
Thymus8.55
Thyroid14.9
Tongue14.15
Tonsil12.15
Trachea11.6
TrigeminalGanglion29.3
Uterus10.4
UterusCorpus12.65
WholeBlood12.5
Wholebrain9.45
colon13.05
pineal_day22.2
pineal_night19.92
retina15.775
small_intestine10.65
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P246787
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.86 ± 0.42
Basal Forebrain6.38 ± 0.28
Basal Part of Pons5.56 ± 0.29
Cerebellar Cortex5.52 ± 0.2
Cerebellar Nuclei6.56 ± 0.31
Claustrum5.63 ± 0.65
Epithalamus6.99 ± 0.36
Frontal Lobe5.95 ± 0.51
Globus Pallidus7.49 ± 0.32
Hypothalamus6.17 ± 0.3
Insula5.88 ± 0.33
Limbic Lobe5.76 ± 0.65
Mesencephalon6.34 ± 0.43
Myelencephalon6.16 ± 0.53
Occipital Lobe6.13 ± 0.6
Parietal Lobe5.97 ± 0.43
Pontine Tegmentum6.17 ± 0.46
Striatum6.93 ± 0.54
Subthalamus5.98 ± 0.23
Temporal Lobe5.88 ± 0.35
Thalamus6.32 ± 0.48
White Matter7.89 ± 0.42
Mouse Brain ISH
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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