AutismKB 2.0

Annotation Detail for RET


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Basic Information Top
Gene Symbol:RET ( CDHF12,CDHR16,HSCR1,MEN2A,MEN2B,MTC1,PTC,RET-ELE1,RET51 )
Gene Full Name: ret proto-oncogene
Band: 10q11.21
Quick LinksEntrez ID:5979; OMIM: 164761; Uniprot ID:RET_HUMAN; ENSEMBL ID: ENSG00000165731; HGNC ID: 9967
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus6 / 56401210
neonate0 / 310970 
infant0 / 236200 
juvenile3 / 5555653
adult12 / 19391216
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma0 / 174750 
breast (mammary gland) tumor4 / 9417842
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor1 / 2638453
glioma0 / 1068830 
head and neck tumor0 / 1363020 
kidney tumor1 / 6895914
leukemia1 / 9584210
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal24 / 33603077
ovarian tumor0 / 766820 
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS49 / 125680389
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites0 / 400150 
bladder0 / 297570 
blood1 / 1234788
bone0 / 716550 
bone marrow0 / 488010 
brain38 / 110098934
cervix0 / 481710 
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus0 / 202090 
eye4 / 21105418
heart1 / 8962611
intestine0 / 2344720 
kidney1 / 2117774
larynx0 / 241450 
liver1 / 2077434
lung0 / 3369740 
lymph0 / 442700 
lymph node0 / 916100 
mammary gland6 / 15327139
mouth0 / 670520 
muscle0 / 1077150 
nerve1 / 1576863
ovary0 / 1020510 
pancreas1 / 2148124
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate2 / 18934510
salivary gland0 / 201550 
skin0 / 2105740 
spleen0 / 539520 
stomach0 / 966190 
testis2 / 3304426
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus0 / 2328780 
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 215771_x_at
Cell line Expression level Expression bar
721_B_lymphoblasts5.25
Adipocyte4.2
AdrenalCortex4.45
Adrenalgland3.75
Amygdala4.45
Appendix6.45
AtrioventricularNode3.4
BDCA4+_DentriticCells4.65
Bonemarrow4.4
BronchialEpithelialCells4.15
CD105+_Endothelial4.35
CD14+_Monocytes4.6
CD19+_BCells(neg._sel.)4.5
CD33+_Myeloid5.35
CD34+5.3
CD4+_Tcells4.55
CD56+_NKCells5.2
CD71+_EarlyErythroid4
CD8+_Tcells4
CardiacMyocytes5.85
Caudatenucleus3.8
Cerebellum3.6
CerebellumPeduncles5
CiliaryGanglion4.4
CingulateCortex4.75
Colorectaladenocarcinoma4.3
DorsalRootGanglion3.55
FetalThyroid4.1
Fetalbrain4.2
Fetalliver3.7
Fetallung3.45
GlobusPallidus3.2
Heart5.4
Hypothalamus4.75
Kidney3.6
Leukemia_chronicMyelogenousK-5623.85
Leukemia_promyelocytic-HL-603.75
Leukemialymphoblastic(MOLT-4)3.45
Liver5.65
Lung4.6
Lymphnode3.6
Lymphoma_burkitts(Daudi)5.4
Lymphoma_burkitts(Raji)5.95
MedullaOblongata5.8
OccipitalLobe3.85
OlfactoryBulb3.35
Ovary2.85
Pancreas3.45
PancreaticIslet4.6
ParietalLobe4.9
Pituitary5.25
Placenta4.4
Pons4.85
PrefrontalCortex5.25
Prostate5.05
Salivarygland3.5
SkeletalMuscle11.25
Skin3.6
SmoothMuscle4.8
Spinalcord4.55
SubthalamicNucleus4.05
SuperiorCervicalGanglion6.7
TemporalLobe3.95
Testis3.75
TestisGermCell3.65
TestisIntersitial3.55
TestisLeydigCell4.2
TestisSeminiferousTubule3.7
Thalamus4.4
Thymus3.4
Thyroid5.25
Tongue4.4
Tonsil4.15
Trachea3.6
TrigeminalGanglion4.4
Uterus3.4
UterusCorpus8.2
WholeBlood4.65
Wholebrain3.5
colon4.25
pineal_day5.28
pineal_night5.14
retina5.325
small_intestine4.1
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_16248_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.28 ± 1.11
Basal Forebrain2.05 ± 0.35
Basal Part of Pons2.82 ± 0.54
Cerebellar Cortex2.72 ± 0.69
Cerebellar Nuclei3.02 ± 0.81
Claustrum2.71 ± 0.89
Epithalamus2.02 ± 1.16
Frontal Lobe2.19 ± 0.87
Globus Pallidus2.38 ± 0.75
Hypothalamus2.86 ± 0.67
Insula1.74 ± 0.91
Limbic Lobe1.93 ± 0.75
Mesencephalon3 ± 1.15
Myelencephalon2.22 ± 0.86
Occipital Lobe2.51 ± 0.99
Parietal Lobe2.49 ± 0.81
Pontine Tegmentum2.05 ± 0.78
Striatum1.45 ± 0.56
Subthalamus2.62 ± 0.34
Temporal Lobe1.99 ± 0.9
Thalamus2.14 ± 0.83
White Matter1.84 ± 0.22
Mouse Brain ISH
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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