AutismKB 2.0

Annotation Detail for REV3L


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Basic Information Top
Gene Symbol:REV3L ( POLZ,REV3 )
Gene Full Name: REV3-like, catalytic subunit of DNA polymerase zeta (yeast)
Band: 6q21
Quick LinksEntrez ID:5980; OMIM: 602776; Uniprot ID:DPOLZ_HUMAN; ENSEMBL ID: ENSG00000009413; HGNC ID: 9968
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body3 / 7076142
blastocyst1 / 6231916
fetus26 / 56401246
neonate2 / 3109764
infant1 / 2362042
juvenile1 / 5555617
adult76 / 193912139
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma2 / 17475114
breast (mammary gland) tumor0 / 941780 
cervical tumor1 / 3436629
chondrosarcoma2 / 8282324
colorectal tumor5 / 11424643
esophageal tumor0 / 172900 
gastrointestinal tumor6 / 11936950
germ cell tumor9 / 26384534
glioma0 / 1068830 
head and neck tumor3 / 13630222
kidney tumor4 / 6895958
leukemia6 / 9584262
liver tumor1 / 9635910
lung tumor1 / 1031279
lymphoma1 / 7175513
non-neoplasia6 / 9725061
normal137 / 336030740
ovarian tumor3 / 7668239
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer1 / 1026809
retinoblastoma2 / 4635643
skin tumor3 / 12494924
soft tissue/muscle tissue tumor11 / 12519187
uterine tumor3 / 9025733
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue2 / 13106152
adrenal gland0 / 331970 
ascites3 / 4001574
bladder3 / 29757100
blood5 / 12347840
bone0 / 716550 
bone marrow2 / 4880140
brain27 / 110098924
cervix1 / 4817120
connective tissue7 / 14925546
ear1 / 1621261
embryonic tissue8 / 21572237
esophagus0 / 202090 
eye17 / 21105480
heart0 / 896260 
intestine8 / 23447234
kidney5 / 21177723
larynx0 / 241450 
liver6 / 20774328
lung6 / 33697417
lymph1 / 4427022
lymph node8 / 9161087
mammary gland4 / 15327126
mouth0 / 670520 
muscle11 / 107715102
nerve0 / 157680 
ovary2 / 10205119
pancreas5 / 21481223
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland1 / 1658560
placenta5 / 28082517
prostate4 / 18934521
salivary gland1 / 2015549
skin3 / 21057414
spleen1 / 5395218
stomach4 / 9661941
testis6 / 33044218
thymus3 / 8113136
thyroid2 / 4747342
tonsil1 / 1699958
trachea3 / 5241357
umbilical cord2 / 13680146
uterus15 / 23287864
vascular6 / 51780115
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 208070_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts63.5
Adipocyte95.4
AdrenalCortex8.5
Adrenalgland7.8
Amygdala35.4
Appendix11.55
AtrioventricularNode7
BDCA4+_DentriticCells11
Bonemarrow7.6
BronchialEpithelialCells7.95
CD105+_Endothelial39.5
CD14+_Monocytes17.45
CD19+_BCells(neg._sel.)11.9
CD33+_Myeloid16.55
CD34+24.05
CD4+_Tcells23.8
CD56+_NKCells26.1
CD71+_EarlyErythroid8.8
CD8+_Tcells24
CardiacMyocytes11.5
Caudatenucleus8.15
Cerebellum7.4
CerebellumPeduncles12.8
CiliaryGanglion6.45
CingulateCortex9.5
Colorectaladenocarcinoma8.8
DorsalRootGanglion7.05
FetalThyroid9.6
Fetalbrain110.95
Fetalliver7.65
Fetallung45.8
GlobusPallidus8
Heart10.15
Hypothalamus18.85
Kidney6.2
Leukemia_chronicMyelogenousK-5627.95
Leukemia_promyelocytic-HL-6014.55
Leukemialymphoblastic(MOLT-4)7.25
Liver10.35
Lung7.95
Lymphnode11.4
Lymphoma_burkitts(Daudi)15.8
Lymphoma_burkitts(Raji)14.85
MedullaOblongata8.2
OccipitalLobe8.4
OlfactoryBulb6.65
Ovary7.75
Pancreas7.35
PancreaticIslet9.95
ParietalLobe10.2
Pituitary11.3
Placenta7.1
Pons8.65
PrefrontalCortex13.95
Prostate10
Salivarygland7.4
SkeletalMuscle9.1
Skin12.1
SmoothMuscle10.6
Spinalcord9.8
SubthalamicNucleus9.2
SuperiorCervicalGanglion10.3
TemporalLobe8.45
Testis6.5
TestisGermCell11.95
TestisIntersitial9.85
TestisLeydigCell10.2
TestisSeminiferousTubule9.15
Thalamus9.5
Thymus6.05
Thyroid15.35
Tongue8.8
Tonsil8.75
Trachea7.6
TrigeminalGanglion9.1
Uterus354.8
UterusCorpus8.35
WholeBlood9.4
Wholebrain6.1
colon11.45
pineal_day46.9
pineal_night33.8
retina13.2
small_intestine8.75
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_14551_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.15 ± 0.39
Basal Forebrain6.05 ± 0.18
Basal Part of Pons5.36 ± 0.24
Cerebellar Cortex6.31 ± 0.28
Cerebellar Nuclei5.67 ± 0.28
Claustrum5.94 ± 0.51
Epithalamus5.69 ± 0.43
Frontal Lobe5.59 ± 0.39
Globus Pallidus5.96 ± 0.53
Hypothalamus5.81 ± 0.34
Insula5.65 ± 0.63
Limbic Lobe6.08 ± 0.46
Mesencephalon5.95 ± 0.43
Myelencephalon5.85 ± 0.41
Occipital Lobe6.29 ± 0.44
Parietal Lobe5.84 ± 0.43
Pontine Tegmentum5.83 ± 0.43
Striatum5.71 ± 0.47
Subthalamus5.3 ± 0.48
Temporal Lobe5.81 ± 0.38
Thalamus5.75 ± 0.42
White Matter5.9 ± 0.39
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Rev3lCBCerebellum22.3
22.73
Rev3lCTXCerebral cortex25.48
17.27
Rev3lHIPHippocampal region31.28
31.19
Rev3lHPFHippocampal formation30.41
27.23
Rev3lHYHypothalamus21.56
16.05
Rev3lLSXLateral septal complex45.93
33.79
Rev3lMBMidbrain16.05
12.65
Rev3lMYMedulla13.92
12.73
Rev3lOLFOlfactory bulb37.11
30.14
Rev3lPPons10.69
9.65
Rev3lPALPallidum15.66
12.21
Rev3lRHPRetrohippocampal region29.48
22.36
Rev3lsAMYStriatum-like amygdalar nuclei21.19
14.62
Rev3lSTRStriatum10.63
7.41
Rev3lSTRdStriatum dorsal region4.6
3.31
Rev3lSTRvStriatum ventral region11.37
7
Rev3lTHThalamus9.1
6.88
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
DPOLZ_HUMAN_1065 8 1065 1072 TNNENIKR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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