AutismKB 2.0

Annotation Detail for RGS1


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Basic Information Top
Gene Symbol:RGS1 ( 1R20,BL34,IER1,IR20 )
Gene Full Name: regulator of G-protein signaling 1
Band: 1q31.2
Quick LinksEntrez ID:5996; OMIM: 600323; Uniprot ID:RGS1_HUMAN; ENSEMBL ID: ENSG00000090104; HGNC ID: 9991
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus8 / 56401214
neonate0 / 310970 
infant0 / 236200 
juvenile3 / 5555653
adult92 / 193912147
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma0 / 174750 
breast (mammary gland) tumor1 / 9417810
cervical tumor0 / 343660 
chondrosarcoma5 / 8282360
colorectal tumor3 / 11424626
esophageal tumor0 / 172900 
gastrointestinal tumor3 / 11936925
germ cell tumor6 / 26384522
glioma1 / 1068839
head and neck tumor5 / 13630236
kidney tumor3 / 6895943
leukemia0 / 958420 
liver tumor2 / 9635920
lung tumor2 / 10312719
lymphoma4 / 7175555
non-neoplasia12 / 97250123
normal205 / 336030761
ovarian tumor3 / 7668239
pancreatic tumor7 / 10461666
primitive neuroectodermal tumor of the CNS1 / 1256807
prostate cancer1 / 1026809
retinoblastoma0 / 463560 
skin tumor11 / 12494988
soft tissue/muscle tissue tumor6 / 12519147
uterine tumor7 / 9025777
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland4 / 33197120
ascites0 / 400150 
bladder7 / 29757235
blood9 / 12347872
bone2 / 7165527
bone marrow10 / 48801204
brain98 / 110098989
cervix0 / 481710 
connective tissue9 / 14925560
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus0 / 202090 
eye11 / 21105452
heart1 / 8962611
intestine14 / 23447259
kidney15 / 21177770
larynx3 / 24145124
liver6 / 20774328
lung20 / 33697459
lymph0 / 442700 
lymph node5 / 9161054
mammary gland1 / 1532716
mouth2 / 6705229
muscle1 / 1077159
nerve3 / 15768190
ovary4 / 10205139
pancreas25 / 214812116
parathyroid0 / 205390 
pharynx1 / 4132824
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate7 / 18934536
salivary gland0 / 201550 
skin11 / 21057452
spleen2 / 5395237
stomach4 / 9661941
testis7 / 33044221
thymus32 / 81131394
thyroid0 / 474730 
tonsil0 / 169990 
trachea45 / 52413858
umbilical cord0 / 136800 
uterus19 / 23287881
vascular4 / 5178077
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 216834_at
Cell line Expression level Expression bar
721_B_lymphoblasts1412.4
Adipocyte7.15
AdrenalCortex21.5
Adrenalgland7.15
Amygdala8.5
Appendix45
AtrioventricularNode13.1
BDCA4+_DentriticCells2125.5
Bonemarrow8.2
BronchialEpithelialCells6.45
CD105+_Endothelial8.5
CD14+_Monocytes8.65
CD19+_BCells(neg._sel.)54.4
CD33+_Myeloid79.25
CD34+73.25
CD4+_Tcells82.05
CD56+_NKCells425.1
CD71+_EarlyErythroid7.7
CD8+_Tcells61.55
CardiacMyocytes10.8
Caudatenucleus7.4
Cerebellum6.15
CerebellumPeduncles9.3
CiliaryGanglion22.95
CingulateCortex7.85
Colorectaladenocarcinoma6.4
DorsalRootGanglion56.1
FetalThyroid7.95
Fetalbrain79.35
Fetalliver6.45
Fetallung27.25
GlobusPallidus6.05
Heart10.7
Hypothalamus221.6
Kidney6.65
Leukemia_chronicMyelogenousK-5626.55
Leukemia_promyelocytic-HL-60112.85
Leukemialymphoblastic(MOLT-4)4.65
Liver10.9
Lung48.6
Lymphnode723.9
Lymphoma_burkitts(Daudi)10.5
Lymphoma_burkitts(Raji)475.25
MedullaOblongata6.35
OccipitalLobe6.7
OlfactoryBulb2985.75
Ovary5.5
Pancreas19.7
PancreaticIslet437.05
ParietalLobe8.7
Pituitary15.35
Placenta6.2
Pons7.85
PrefrontalCortex8.7
Prostate9.4
Salivarygland491.45
SkeletalMuscle9.65
Skin6.75
SmoothMuscle8.8
Spinalcord823.8
SubthalamicNucleus7.5
SuperiorCervicalGanglion24.85
TemporalLobe7.5
Testis5.85
TestisGermCell5.9
TestisIntersitial6.5
TestisLeydigCell8.1
TestisSeminiferousTubule6.8
Thalamus9.1
Thymus50
Thyroid22.15
Tongue8.05
Tonsil228
Trachea131.9
TrigeminalGanglion26.2
Uterus6.8
UterusCorpus7.5
WholeBlood7.5
Wholebrain4.8
colon112.9
pineal_day9.7
pineal_night9.18
retina280.7
small_intestine485.1
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_9828_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.47 ± 1.03
Basal Forebrain2.2 ± 0.31
Basal Part of Pons2.46 ± 1.17
Cerebellar Cortex1.92 ± 0.78
Cerebellar Nuclei3.39 ± 1.04
Claustrum3.16 ± 0.93
Epithalamus4.53 ± 1.22
Frontal Lobe2.1 ± 0.91
Globus Pallidus3.9 ± 0.74
Hypothalamus2.86 ± 2.03
Insula2.11 ± 0.79
Limbic Lobe2.09 ± 0.65
Mesencephalon2.28 ± 0.74
Myelencephalon2.32 ± 0.99
Occipital Lobe2.15 ± 0.57
Parietal Lobe2.24 ± 0.85
Pontine Tegmentum2.12 ± 0.81
Striatum2.71 ± 1.03
Subthalamus2.34 ± 0.32
Temporal Lobe2.13 ± 0.99
Thalamus2.01 ± 0.62
White Matter6.02 ± 1.13
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Rgs1CBCerebellum2.98
3.45
Rgs1CTXCerebral cortex2.06
1.59
Rgs1HIPHippocampal region2.11
1.76
Rgs1HPFHippocampal formation3.54
3
Rgs1HYHypothalamus0.44
0.49
Rgs1LSXLateral septal complex0.57
0.95
Rgs1MBMidbrain1.34
1.85
Rgs1MYMedulla3.84
5.09
Rgs1OLFOlfactory bulb10.24
7.93
Rgs1PPons2.35
3.95
Rgs1PALPallidum0.83
1.1
Rgs1RHPRetrohippocampal region6.82
5.38
Rgs1sAMYStriatum-like amygdalar nuclei3.3
2.23
Rgs1STRStriatum1.93
1.44
Rgs1STRdStriatum dorsal region2.07
1.59
Rgs1STRvStriatum ventral region1.57
0.98
Rgs1THThalamus0.97
0.84
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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