AutismKB 2.0

Annotation Detail for RGS3


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Basic Information Top
Gene Symbol:RGS3 ( C2PA,FLJ20370,FLJ31516,FLJ90496,PDZ-RGS3,RGP3 )
Gene Full Name: regulator of G-protein signaling 3
Band: 9q32
Quick LinksEntrez ID:5998; OMIM: 602189; Uniprot ID:RGS3_HUMAN; ENSEMBL ID: ENSG00000138835; HGNC ID: 9999
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body5 / 7076170
blastocyst5 / 6231980
fetus29 / 56401251
neonate0 / 310970 
infant0 / 236200 
juvenile3 / 5555653
adult93 / 193912147
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma0 / 174750 
breast (mammary gland) tumor5 / 9417853
cervical tumor1 / 3436629
chondrosarcoma12 / 82823144
colorectal tumor6 / 11424652
esophageal tumor0 / 172900 
gastrointestinal tumor1 / 1193698
germ cell tumor9 / 26384534
glioma8 / 10688374
head and neck tumor11 / 13630280
kidney tumor8 / 68959116
leukemia3 / 9584231
liver tumor1 / 9635910
lung tumor5 / 10312748
lymphoma3 / 7175541
non-neoplasia14 / 97250143
normal224 / 336030766
ovarian tumor1 / 7668213
pancreatic tumor3 / 10461628
primitive neuroectodermal tumor of the CNS10 / 12568079
prostate cancer3 / 10268029
retinoblastoma1 / 4635621
skin tumor14 / 124949112
soft tissue/muscle tissue tumor6 / 12519147
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland2 / 3319760
ascites1 / 4001524
bladder2 / 2975767
blood2 / 12347816
bone10 / 71655139
bone marrow0 / 488010 
brain76 / 110098969
cervix1 / 4817120
connective tissue20 / 149255133
ear1 / 1621261
embryonic tissue13 / 21572260
esophagus0 / 202090 
eye22 / 211054104
heart8 / 8962689
intestine10 / 23447242
kidney18 / 21177784
larynx0 / 241450 
liver4 / 20774319
lung20 / 33697459
lymph3 / 4427067
lymph node8 / 9161087
mammary gland6 / 15327139
mouth3 / 6705244
muscle2 / 10771518
nerve2 / 15768126
ovary4 / 10205139
pancreas5 / 21481223
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland1 / 1658560
placenta7 / 28082524
prostate6 / 18934531
salivary gland7 / 20155347
skin25 / 210574118
spleen10 / 53952185
stomach1 / 9661910
testis25 / 33044275
thymus5 / 8113161
thyroid3 / 4747363
tonsil0 / 169990 
trachea5 / 5241395
umbilical cord0 / 136800 
uterus10 / 23287842
vascular5 / 5178096
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 203823_at
Cell line Expression level Expression bar
721_B_lymphoblasts68.9
Adipocyte39.05
AdrenalCortex42.45
Adrenalgland46
Amygdala12.65
Appendix72.95
AtrioventricularNode29.75
BDCA4+_DentriticCells33.85
Bonemarrow41.05
BronchialEpithelialCells38.2
CD105+_Endothelial37.15
CD14+_Monocytes117
CD19+_BCells(neg._sel.)43.15
CD33+_Myeloid44.8
CD34+46.85
CD4+_Tcells50.9
CD56+_NKCells861.5
CD71+_EarlyErythroid13.7
CD8+_Tcells91.3
CardiacMyocytes99.5
Caudatenucleus36.7
Cerebellum33.1
CerebellumPeduncles40.7
CiliaryGanglion49
CingulateCortex73.35
Colorectaladenocarcinoma29.05
DorsalRootGanglion32.5
FetalThyroid60.15
Fetalbrain35.2
Fetalliver35.8
Fetallung105.3
GlobusPallidus38.8
Heart593.05
Hypothalamus65.15
Kidney39.65
Leukemia_chronicMyelogenousK-56236.05
Leukemia_promyelocytic-HL-6037.45
Leukemialymphoblastic(MOLT-4)32.3
Liver55.3
Lung128.7
Lymphnode43.45
Lymphoma_burkitts(Daudi)52.45
Lymphoma_burkitts(Raji)96.3
MedullaOblongata38.4
OccipitalLobe36.2
OlfactoryBulb31.1
Ovary26.35
Pancreas32.95
PancreaticIslet41.75
ParietalLobe44
Pituitary39.65
Placenta42
Pons46.05
PrefrontalCortex42.25
Prostate40.4
Salivarygland31.45
SkeletalMuscle48.25
Skin32.5
SmoothMuscle85.6
Spinalcord55.05
SubthalamicNucleus38.2
SuperiorCervicalGanglion49.75
TemporalLobe38.7
Testis63
TestisGermCell44.55
TestisIntersitial46.55
TestisLeydigCell57.8
TestisSeminiferousTubule49.8
Thalamus301.1
Thymus31.05
Thyroid48.85
Tongue41
Tonsil40.45
Trachea32.6
TrigeminalGanglion60.65
Uterus36.05
UterusCorpus42.6
WholeBlood75.35
Wholebrain36.85
colon39.25
pineal_day173.04
pineal_night189.7
retina48.65
small_intestine25.35
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_5557_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.24 ± 1.01
Basal Forebrain1.91 ± 0.43
Basal Part of Pons1.92 ± 0.64
Cerebellar Cortex1.85 ± 0.79
Cerebellar Nuclei2.02 ± 0.7
Claustrum2.68 ± 1.06
Epithalamus1.66 ± 0.66
Frontal Lobe1.83 ± 0.72
Globus Pallidus2.12 ± 0.65
Hypothalamus1.83 ± 0.9
Insula1.92 ± 0.83
Limbic Lobe2.05 ± 0.79
Mesencephalon2.13 ± 0.67
Myelencephalon2.01 ± 0.67
Occipital Lobe2.02 ± 0.88
Parietal Lobe2.01 ± 0.73
Pontine Tegmentum1.82 ± 0.75
Striatum2.03 ± 0.68
Subthalamus2.08 ± 0.23
Temporal Lobe1.91 ± 0.71
Thalamus2.06 ± 0.68
White Matter2.87 ± 0.35
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Rgs3CBCerebellum26.84
27.26
Rgs3CTXCerebral cortex4.17
2.69
Rgs3HIPHippocampal region7.83
4.81
Rgs3HPFHippocampal formation10.84
7.9
Rgs3HYHypothalamus3.48
2.27
Rgs3LSXLateral septal complex2.21
1.37
Rgs3MBMidbrain5.45
4.04
Rgs3MYMedulla8.86
6.82
Rgs3OLFOlfactory bulb13.77
8.67
Rgs3PPons5.64
4.62
Rgs3PALPallidum1.44
1.2
Rgs3RHPRetrohippocampal region17.26
12.91
Rgs3sAMYStriatum-like amygdalar nuclei1.09
0.86
Rgs3STRStriatum1.38
0.98
Rgs3STRdStriatum dorsal region1.02
0.8
Rgs3STRvStriatum ventral region2.15
1.25
Rgs3THThalamus31.78
26.85
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp01039315 13 960 972 TTLHCSDGEGAAS Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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