AutismKB 2.0

Annotation Detail for RGS4


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Basic Information Top
Gene Symbol:RGS4 ( DKFZp761F1924,MGC2124,MGC60244,RGP4,SCZD9 )
Gene Full Name: regulator of G-protein signaling 4
Band: 1q23.3
Quick LinksEntrez ID:5999; OMIM: 602516; Uniprot ID:RGS4_HUMAN; ENSEMBL ID: ENSG00000117152; HGNC ID: 10000
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body11 / 70761155
blastocyst1 / 6231916
fetus8 / 56401214
neonate10 / 31097321
infant3 / 23620127
juvenile17 / 55556305
adult63 / 193912132
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma0 / 174750 
breast (mammary gland) tumor1 / 9417810
cervical tumor0 / 343660 
chondrosarcoma4 / 8282348
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor28 / 263845106
glioma9 / 10688384
head and neck tumor6 / 13630244
kidney tumor13 / 68959188
leukemia1 / 9584210
liver tumor1 / 9635910
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia7 / 9725071
normal1162 / 3360307345
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS44 / 125680350
prostate cancer1 / 1026809
retinoblastoma0 / 463560 
skin tumor5 / 12494940
soft tissue/muscle tissue tumor21 / 125191167
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites0 / 400150 
bladder1 / 2975733
blood0 / 1234780 
bone2 / 7165527
bone marrow3 / 4880161
brain535 / 1100989485
cervix0 / 481710 
connective tissue15 / 149255100
ear0 / 162120 
embryonic tissue13 / 21572260
esophagus0 / 202090 
eye16 / 21105475
heart0 / 896260 
intestine2 / 2344728
kidney519 / 2117772450
larynx0 / 241450 
liver2 / 2077439
lung2 / 3369745
lymph0 / 442700 
lymph node0 / 916100 
mammary gland1 / 1532716
mouth1 / 6705214
muscle0 / 1077150 
nerve5 / 15768317
ovary1 / 1020519
pancreas12 / 21481255
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate3 / 18934515
salivary gland0 / 201550 
skin12 / 21057456
spleen1 / 5395218
stomach1 / 9661910
testis4 / 33044212
thymus1 / 8113112
thyroid5 / 47473105
tonsil0 / 169990 
trachea6 / 52413114
umbilical cord3 / 13680219
uterus25 / 232878107
vascular160 / 517803089
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 204337_at
Cell line Expression level Expression bar
721_B_lymphoblasts4.1
Adipocyte3.25
AdrenalCortex4.05
Adrenalgland5.4
Amygdala590.95
Appendix4.25
AtrioventricularNode2.7
BDCA4+_DentriticCells3.65
Bonemarrow3.25
BronchialEpithelialCells3.25
CD105+_Endothelial3.35
CD14+_Monocytes3.5
CD19+_BCells(neg._sel.)3.5
CD33+_Myeloid4.25
CD34+4.2
CD4+_Tcells3.6
CD56+_NKCells3.9
CD71+_EarlyErythroid3.1
CD8+_Tcells3.25
CardiacMyocytes402.75
Caudatenucleus270.8
Cerebellum2.7
CerebellumPeduncles3.75
CiliaryGanglion55.65
CingulateCortex888.55
Colorectaladenocarcinoma3.3
DorsalRootGanglion47.7
FetalThyroid4.45
Fetalbrain3.3
Fetalliver2.85
Fetallung2.75
GlobusPallidus640.65
Heart4.25
Hypothalamus117.5
Kidney2.7
Leukemia_chronicMyelogenousK-5622.95
Leukemia_promyelocytic-HL-602.9
Leukemialymphoblastic(MOLT-4)2.65
Liver4.35
Lung3.6
Lymphnode2.9
Lymphoma_burkitts(Daudi)4.2
Lymphoma_burkitts(Raji)4.6
MedullaOblongata890.45
OccipitalLobe1276.3
OlfactoryBulb2.6
Ovary2.2
Pancreas2.65
PancreaticIslet129.25
ParietalLobe766.7
Pituitary52.1
Placenta3.4
Pons450
PrefrontalCortex1207.1
Prostate3.9
Salivarygland2.65
SkeletalMuscle3.85
Skin2.55
SmoothMuscle528.95
Spinalcord6.05
SubthalamicNucleus852.3
SuperiorCervicalGanglion9.2
TemporalLobe735.55
Testis2.85
TestisGermCell2.75
TestisIntersitial2.8
TestisLeydigCell3.3
TestisSeminiferousTubule2.85
Thalamus43.95
Thymus2.6
Thyroid4.2
Tongue3.35
Tonsil3.2
Trachea2.8
TrigeminalGanglion44.1
Uterus2.8
UterusCorpus3.05
WholeBlood3.6
Wholebrain729.05
colon3.35
pineal_day4.2
pineal_night4.06
retina11.05
small_intestine3.25
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_537_PI416408490
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala8.12 ± 0.78
Basal Forebrain7.37 ± 0.52
Basal Part of Pons9.54 ± 0.48
Cerebellar Cortex7.17 ± 0.55
Cerebellar Nuclei9.09 ± 0.79
Claustrum8.14 ± 1.33
Epithalamus7.58 ± 1.07
Frontal Lobe9.2 ± 0.67
Globus Pallidus6.65 ± 1.88
Hypothalamus9.06 ± 0.62
Insula8.88 ± 0.44
Limbic Lobe8.33 ± 1.3
Mesencephalon8.37 ± 1.16
Myelencephalon8.35 ± 1.16
Occipital Lobe7.59 ± 1.37
Parietal Lobe8.86 ± 1
Pontine Tegmentum8.4 ± 0.76
Striatum7.61 ± 1.93
Subthalamus8.97 ± 0.45
Temporal Lobe8.82 ± 0.74
Thalamus7.82 ± 0.66
White Matter6 ± 1.75
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Rgs4CBCerebellum9.17
10.8
Rgs4CTXCerebral cortex100
100
Rgs4HIPHippocampal region41.78
55.82
Rgs4HPFHippocampal formation58.06
64.75
Rgs4HYHypothalamus34.89
38.42
Rgs4LSXLateral septal complex21.92
22.47
Rgs4MBMidbrain22.62
25.73
Rgs4MYMedulla35.77
57.82
Rgs4OLFOlfactory bulb85.36
87
Rgs4PPons33.31
52.88
Rgs4PALPallidum41.94
52.29
Rgs4RHPRetrohippocampal region83.28
79.33
Rgs4sAMYStriatum-like amygdalar nuclei60.7
58.99
Rgs4STRStriatum100
100
Rgs4STRdStriatum dorsal region100
100
Rgs4STRvStriatum ventral region92.38
89.09
Rgs4THThalamus81.58
100
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
RGS4_HUMAN_156 7 156 162 IFNLMEK PRIDE
RGS4_HUMAN_173 15 173 187 FYLDLVNPSSCGAEK PRIDE
RGS4_HUMAN_4 11 4 14 GLAGLPASCLR PRIDE
RGS4_HUMAN_51 7 51 57 VSQEEVK PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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