AutismKB 2.0

Annotation Detail for RGS12


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Basic Information Top
Gene Symbol:RGS12 ( DKFZp761K1617,DKFZp761K1817 )
Gene Full Name: regulator of G-protein signaling 12
Band: 4p16.3
Quick LinksEntrez ID:6002; OMIM: 602512; Uniprot ID:RGS12_HUMAN; ENSEMBL ID: ENSG00000159788; HGNC ID: 9994
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body2 / 7076128
blastocyst3 / 6231948
fetus44 / 56401278
neonate0 / 310970 
infant0 / 236200 
juvenile1 / 5555617
adult79 / 193912140
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor5 / 9417853
cervical tumor0 / 343660 
chondrosarcoma4 / 8282348
colorectal tumor3 / 11424626
esophageal tumor1 / 1729057
gastrointestinal tumor2 / 11936916
germ cell tumor7 / 26384526
glioma17 / 106883159
head and neck tumor0 / 1363020 
kidney tumor2 / 6895929
leukemia2 / 9584220
liver tumor1 / 9635910
lung tumor2 / 10312719
lymphoma0 / 717550 
non-neoplasia6 / 9725061
normal159 / 336030747
ovarian tumor6 / 7668278
pancreatic tumor6 / 10461657
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer3 / 10268029
retinoblastoma0 / 463560 
skin tumor15 / 124949120
soft tissue/muscle tissue tumor3 / 12519123
uterine tumor9 / 9025799
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone3 / 7165541
bone marrow1 / 4880120
brain74 / 110098967
cervix2 / 4817141
connective tissue3 / 14925520
ear0 / 162120 
embryonic tissue8 / 21572237
esophagus1 / 2020949
eye21 / 21105499
heart5 / 8962655
intestine15 / 23447263
kidney18 / 21177784
larynx0 / 241450 
liver2 / 2077439
lung37 / 336974109
lymph0 / 442700 
lymph node4 / 9161043
mammary gland8 / 15327152
mouth1 / 6705214
muscle3 / 10771527
nerve1 / 1576863
ovary6 / 10205158
pancreas9 / 21481241
parathyroid1 / 2053948
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta4 / 28082514
prostate5 / 18934526
salivary gland0 / 201550 
skin17 / 21057480
spleen2 / 5395237
stomach2 / 9661920
testis4 / 33044212
thymus4 / 8113149
thyroid1 / 4747321
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord0 / 136800 
uterus13 / 23287855
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 209639_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts13.3
Adipocyte15.35
AdrenalCortex25.25
Adrenalgland13
Amygdala20.95
Appendix20.65
AtrioventricularNode25.25
BDCA4+_DentriticCells15.3
Bonemarrow18.1
BronchialEpithelialCells14.5
CD105+_Endothelial16.05
CD14+_Monocytes16.2
CD19+_BCells(neg._sel.)15.1
CD33+_Myeloid18.3
CD34+21.6
CD4+_Tcells17.45
CD56+_NKCells17.75
CD71+_EarlyErythroid15.8
CD8+_Tcells15.4
CardiacMyocytes37.55
Caudatenucleus14.2
Cerebellum12.95
CerebellumPeduncles23.85
CiliaryGanglion13.35
CingulateCortex21.65
Colorectaladenocarcinoma20.4
DorsalRootGanglion14.45
FetalThyroid16.05
Fetalbrain15.8
Fetalliver14.85
Fetallung13.1
GlobusPallidus18.75
Heart37.4
Hypothalamus16.3
Kidney13.8
Leukemia_chronicMyelogenousK-56214.55
Leukemia_promyelocytic-HL-6013.1
Leukemialymphoblastic(MOLT-4)12.25
Liver21.45
Lung18
Lymphnode12.7
Lymphoma_burkitts(Daudi)20.65
Lymphoma_burkitts(Raji)27.65
MedullaOblongata16.5
OccipitalLobe14.6
OlfactoryBulb12.6
Ovary14.15
Pancreas12.45
PancreaticIslet17.55
ParietalLobe19.4
Pituitary19.35
Placenta12.9
Pons19.5
PrefrontalCortex23.55
Prostate23.85
Salivarygland15.95
SkeletalMuscle25.75
Skin18.5
SmoothMuscle17.95
Spinalcord16.95
SubthalamicNucleus15.7
SuperiorCervicalGanglion31.4
TemporalLobe21
Testis13.8
TestisGermCell13.25
TestisIntersitial13.75
TestisLeydigCell18.15
TestisSeminiferousTubule14.2
Thalamus16.8
Thymus12.65
Thyroid20.85
Tongue20.9
Tonsil16.45
Trachea13.4
TrigeminalGanglion32.5
Uterus12.95
UterusCorpus14.9
WholeBlood15.95
Wholebrain13.4
colon15.95
pineal_day21.5
pineal_night20.14
retina19.85
small_intestine15.35
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P33705
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.87 ± 0.6
Basal Forebrain5.21 ± 0.18
Basal Part of Pons4.43 ± 0.43
Cerebellar Cortex5.01 ± 0.26
Cerebellar Nuclei4.2 ± 0.39
Claustrum4.42 ± 0.68
Epithalamus5.47 ± 0.4
Frontal Lobe4.36 ± 0.57
Globus Pallidus5.04 ± 0.52
Hypothalamus4.97 ± 0.33
Insula4.36 ± 0.71
Limbic Lobe4.57 ± 0.66
Mesencephalon4.53 ± 0.49
Myelencephalon4.62 ± 0.6
Occipital Lobe4.74 ± 0.52
Parietal Lobe4.42 ± 0.63
Pontine Tegmentum4.52 ± 0.73
Striatum4.63 ± 0.64
Subthalamus4.39 ± 0.25
Temporal Lobe4.5 ± 0.55
Thalamus4.48 ± 0.42
White Matter5.05 ± 0.32
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Rgs12CBCerebellum21.89
48.94
Rgs12CTXCerebral cortex96.69
100
Rgs12HIPHippocampal region29.33
50.14
Rgs12HPFHippocampal formation51.22
77.7
Rgs12HYHypothalamus9.11
6.93
Rgs12LSXLateral septal complex27.61
23.49
Rgs12MBMidbrain9.23
9.49
Rgs12MYMedulla16.58
18.34
Rgs12OLFOlfactory bulb71.15
76.56
Rgs12PPons12.39
12.82
Rgs12PALPallidum19.98
20.61
Rgs12RHPRetrohippocampal region84.16
97.65
Rgs12sAMYStriatum-like amygdalar nuclei31.74
30.22
Rgs12STRStriatum48.81
44.62
Rgs12STRdStriatum dorsal region50.59
45.93
Rgs12STRvStriatum ventral region60.01
54.16
Rgs12THThalamus14.12
13.08
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
RGS12_HUMAN_1037 8 1037 1044 LDLVPINR PRIDE
RGS12_HUMAN_1212 10 1212 1221 EDLVLPEFLR PRIDE
RGS12_HUMAN_128 6 128 133 ALGINR PRIDE
RGS12_HUMAN_1294 25 1294 1318 SPSGPFCTPQSPVSLAQEGTAQIWK PRIDE
RGS12_HUMAN_1380 6 1380 1385 DLPVNR PRIDE
RGS12_HUMAN_438 12 438 449 VLVVDLGGSSSR PRIDE
RGS12_HUMAN_50 10 50 59 GSPADFVGLR PRIDE
RGS12_HUMAN_51 9 51 59 SPADFVGLR PRIDE
RGS12_HUMAN_537 8 537 544 WLPVHVLR PRIDE
RGS12_HUMAN_579 5 579 583 IPADR PRIDE
RGS12_HUMAN_634 10 634 643 GTGLTQPSQR PRIDE
RGS12_HUMAN_768 5 768 772 EIFSK PRIDE
RGS12_HUMAN_825 15 825 839 SPLYQECILAEVEGR PRIDE
RGS12_HUMAN_895 8 895 902 GAFFSWSR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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