AutismKB 2.0

Annotation Detail for RHEB


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Basic Information Top
Gene Symbol:RHEB ( MGC111559,RHEB2 )
Gene Full Name: Ras homolog enriched in brain
Band: 7q36.1
Quick LinksEntrez ID:6009; OMIM: 601293; Uniprot ID:RHEB_HUMAN; ENSEMBL ID: ENSG00000106615; HGNC ID: 10011
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst0 / 623190 
fetus12 / 56401221
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult55 / 193912128
embryoid body3 / 7076142
blastocyst4 / 6231964
fetus67 / 564012118
neonate2 / 3109764
infant2 / 2362084
juvenile3 / 5555653
adult242 / 1939121124
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma6 / 8282372
colorectal tumor1 / 1142468
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor3 / 26384511
glioma1 / 1068839
head and neck tumor2 / 13630214
kidney tumor3 / 6895943
leukemia0 / 958420 
liver tumor4 / 9635941
lung tumor2 / 10312719
lymphoma2 / 7175527
non-neoplasia0 / 972500 
normal50 / 336030714
ovarian tumor3 / 7668239
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer1 / 1026809
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor33 / 125191263
uterine tumor2 / 9025722
adrenal tumor0 / 127940 
bladder carcinoma2 / 17475114
breast (mammary gland) tumor7 / 9417874
cervical tumor2 / 3436658
chondrosarcoma5 / 8282360
colorectal tumor5 / 11424643
esophageal tumor1 / 1729057
gastrointestinal tumor14 / 119369117
germ cell tumor35 / 263845132
glioma15 / 106883140
head and neck tumor5 / 13630236
kidney tumor4 / 6895958
leukemia13 / 95842135
liver tumor12 / 96359124
lung tumor5 / 10312748
lymphoma4 / 7175555
non-neoplasia5 / 9725051
normal324 / 336030796
ovarian tumor11 / 76682143
pancreatic tumor2 / 10461619
primitive neuroectodermal tumor of the CNS4 / 12568031
prostate cancer8 / 10268077
retinoblastoma0 / 463560 
skin tumor6 / 12494948
soft tissue/muscle tissue tumor61 / 125191487
uterine tumor3 / 9025733
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone5 / 7165569
bone marrow0 / 488010 
brain11 / 11009899
cervix0 / 481710 
connective tissue33 / 149255221
ear1 / 1621261
embryonic tissue2 / 2157229
esophagus0 / 202090 
eye6 / 21105428
heart0 / 896260 
intestine2 / 2344728
kidney3 / 21177714
larynx0 / 241450 
liver8 / 20774338
lung5 / 33697414
lymph0 / 442700 
lymph node0 / 916100 
mammary gland0 / 1532710 
mouth0 / 670520 
muscle0 / 1077150 
nerve0 / 157680 
ovary4 / 10205139
pancreas6 / 21481227
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate1 / 1893455
salivary gland1 / 2015549
skin1 / 2105744
spleen1 / 5395218
stomach0 / 966190 
testis9 / 33044227
thymus0 / 811310 
thyroid2 / 4747342
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus3 / 23287812
vascular1 / 5178019
adipose tissue2 / 13106152
adrenal gland4 / 33197120
ascites5 / 40015124
bladder2 / 2975767
blood6 / 12347848
bone5 / 7165569
bone marrow4 / 4880181
brain107 / 110098997
cervix3 / 4817162
connective tissue57 / 149255381
ear0 / 162120 
embryonic tissue13 / 21572260
esophagus1 / 2020949
eye17 / 21105480
heart13 / 89626145
intestine21 / 23447289
kidney18 / 21177784
larynx0 / 241450 
liver16 / 20774377
lung44 / 336974130
lymph3 / 4427067
lymph node12 / 91610130
mammary gland10 / 15327165
mouth1 / 6705214
muscle9 / 10771583
nerve0 / 157680 
ovary13 / 102051127
pancreas18 / 21481283
parathyroid1 / 2053948
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta41 / 280825145
prostate19 / 189345100
salivary gland3 / 20155148
skin32 / 210574151
spleen1 / 5395218
stomach8 / 9661982
testis27 / 33044281
thymus4 / 8113149
thyroid4 / 4747384
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord1 / 1368073
uterus25 / 232878107
vascular9 / 51780173
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 201453_x_at
Cell line Expression level Expression bar
721_B_lymphoblasts529.35
Adipocyte597.7
AdrenalCortex541.25
Adrenalgland625.6
Amygdala1357.5
Appendix490.8
AtrioventricularNode244.3
BDCA4+_DentriticCells871.4
Bonemarrow419.75
BronchialEpithelialCells705.75
CD105+_Endothelial1138.2
CD14+_Monocytes572.55
CD19+_BCells(neg._sel.)462.7
CD33+_Myeloid931.15
CD34+1576.7
CD4+_Tcells445.3
CD56+_NKCells486.7
CD71+_EarlyErythroid1434.65
CD8+_Tcells335.95
CardiacMyocytes817.25
Caudatenucleus536.6
Cerebellum443.55
CerebellumPeduncles693.7
CiliaryGanglion356.7
CingulateCortex669.6
Colorectaladenocarcinoma1642.1
DorsalRootGanglion454.35
FetalThyroid498.55
Fetalbrain707.45
Fetalliver365.2
Fetallung575.3
GlobusPallidus457.45
Heart338
Hypothalamus1260.15
Kidney249.4
Leukemia_chronicMyelogenousK-562707.45
Leukemia_promyelocytic-HL-60567.15
Leukemialymphoblastic(MOLT-4)777.1
Liver262.3
Lung758.85
Lymphnode334.8
Lymphoma_burkitts(Daudi)725.15
Lymphoma_burkitts(Raji)843.75
MedullaOblongata620.95
OccipitalLobe866.75
OlfactoryBulb1064.7
Ovary460.3
Pancreas470.6
PancreaticIslet926.4
ParietalLobe639.35
Pituitary639.1
Placenta1467.3
Pons469.25
PrefrontalCortex1027.8
Prostate730.5
Salivarygland427.55
SkeletalMuscle386.2
Skin271.95
SmoothMuscle713.95
Spinalcord806.65
SubthalamicNucleus589.75
SuperiorCervicalGanglion196.35
TemporalLobe762.9
Testis462.55
TestisGermCell521.95
TestisIntersitial468.6
TestisLeydigCell486.2
TestisSeminiferousTubule449.65
Thalamus1126.25
Thymus401.85
Thyroid890.8
Tongue260.75
Tonsil304.7
Trachea354.1
TrigeminalGanglion430.1
Uterus581.5
UterusCorpus737.1
WholeBlood346.15
Wholebrain1451.7
colon498
pineal_day1522.56
pineal_night1595.46
retina1140.85
small_intestine528.2
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P134247
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala9.85 ± 0.25
Basal Forebrain9.77 ± 0.17
Basal Part of Pons10.14 ± 0.18
Cerebellar Cortex9.66 ± 0.21
Cerebellar Nuclei9.9 ± 0.17
Claustrum9.9 ± 0.28
Epithalamus9.62 ± 0.27
Frontal Lobe10.17 ± 0.27
Globus Pallidus9.68 ± 0.41
Hypothalamus10.11 ± 0.24
Insula10.16 ± 0.26
Limbic Lobe9.93 ± 0.5
Mesencephalon9.83 ± 0.32
Myelencephalon9.88 ± 0.4
Occipital Lobe9.51 ± 0.4
Parietal Lobe9.98 ± 0.34
Pontine Tegmentum9.94 ± 0.36
Striatum9.79 ± 0.4
Subthalamus10.27 ± 0.2
Temporal Lobe10.02 ± 0.29
Thalamus9.91 ± 0.23
White Matter8.81 ± 0.14
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
RhebCBCerebellum23.59
93.16
RhebCTXCerebral cortex100
100
RhebHIPHippocampal region98.38
100
RhebHPFHippocampal formation95.59
100
RhebHYHypothalamus44.57
43.57
RhebLSXLateral septal complex42.85
38.11
RhebMBMidbrain35.27
38.79
RhebMYMedulla15.93
27.64
RhebOLFOlfactory bulb67.04
80.02
RhebPPons23.46
34.84
RhebPALPallidum52.17
53.9
RhebRHPRetrohippocampal region91.03
100
RhebsAMYStriatum-like amygdalar nuclei50.16
45.54
RhebSTRStriatum46.11
40.47
RhebSTRdStriatum dorsal region46.52
41.62
RhebSTRvStriatum ventral region41.34
32.75
RhebTHThalamus87.87
97.69
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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