AutismKB 2.0

Annotation Detail for BCL6


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Basic Information Top
Gene Symbol:BCL6 ( BCL5,BCL6A,LAZ3,ZBTB27,ZNF51 )
Gene Full Name: B-cell CLL/lymphoma 6
Band: 3q27.3
Quick LinksEntrez ID:604; OMIM: 109565; Uniprot ID:BCL6_HUMAN; ENSEMBL ID: ENSG00000113916; HGNC ID: 1001
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst3 / 6231948
fetus23 / 56401240
neonate1 / 3109732
infant0 / 236200 
juvenile3 / 5555653
adult119 / 193912161
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma1 / 1747557
breast (mammary gland) tumor1 / 9417810
cervical tumor1 / 3436629
chondrosarcoma2 / 8282324
colorectal tumor1 / 1142468
esophageal tumor0 / 172900 
gastrointestinal tumor5 / 11936941
germ cell tumor3 / 26384511
glioma5 / 10688346
head and neck tumor12 / 13630288
kidney tumor0 / 689590 
leukemia16 / 95842166
liver tumor4 / 9635941
lung tumor4 / 10312738
lymphoma1 / 7175513
non-neoplasia10 / 97250102
normal160 / 336030747
ovarian tumor6 / 7668278
pancreatic tumor7 / 10461666
primitive neuroectodermal tumor of the CNS1 / 1256807
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor7 / 9025777
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue5 / 13106381
adrenal gland1 / 3319730
ascites0 / 400150 
bladder3 / 29757100
blood17 / 123478137
bone1 / 7165513
bone marrow0 / 488010 
brain86 / 110098978
cervix1 / 4817120
connective tissue10 / 14925566
ear0 / 162120 
embryonic tissue5 / 21572223
esophagus0 / 202090 
eye5 / 21105423
heart6 / 8962666
intestine3 / 23447212
kidney4 / 21177718
larynx6 / 24145248
liver5 / 20774324
lung16 / 33697447
lymph1 / 4427022
lymph node13 / 91610141
mammary gland6 / 15327139
mouth6 / 6705289
muscle1 / 1077159
nerve3 / 15768190
ovary7 / 10205168
pancreas9 / 21481241
parathyroid1 / 2053948
pharynx0 / 413280 
pituitary gland1 / 1658560
placenta6 / 28082521
prostate11 / 18934558
salivary gland0 / 201550 
skin2 / 2105749
spleen0 / 539520 
stomach5 / 9661951
testis13 / 33044239
thymus13 / 81131160
thyroid0 / 474730 
tonsil0 / 169990 
trachea6 / 52413114
umbilical cord0 / 136800 
uterus18 / 23287877
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 203140_at
Cell line Expression level Expression bar
721_B_lymphoblasts6.1
Adipocyte252.9
AdrenalCortex32.15
Adrenalgland38.8
Amygdala85.3
Appendix40
AtrioventricularNode95.7
BDCA4+_DentriticCells190.95
Bonemarrow161.65
BronchialEpithelialCells12
CD105+_Endothelial33.55
CD14+_Monocytes799
CD19+_BCells(neg._sel.)183.6
CD33+_Myeloid1320.1
CD34+42.6
CD4+_Tcells25.8
CD56+_NKCells247.8
CD71+_EarlyErythroid5.6
CD8+_Tcells32.4
CardiacMyocytes8.85
Caudatenucleus27.45
Cerebellum353
CerebellumPeduncles213.65
CiliaryGanglion130.9
CingulateCortex45
Colorectaladenocarcinoma7.15
DorsalRootGanglion19.9
FetalThyroid48.35
Fetalbrain58.55
Fetalliver23.65
Fetallung245.9
GlobusPallidus18.75
Heart27.95
Hypothalamus108.05
Kidney7.5
Leukemia_chronicMyelogenousK-56210.9
Leukemia_promyelocytic-HL-60439.25
Leukemialymphoblastic(MOLT-4)5.5
Liver40.45
Lung304.2
Lymphnode47.2
Lymphoma_burkitts(Daudi)429.25
Lymphoma_burkitts(Raji)1287.85
MedullaOblongata34.2
OccipitalLobe37.2
OlfactoryBulb166.7
Ovary72.45
Pancreas34.65
PancreaticIslet234.25
ParietalLobe17.5
Pituitary20.5
Placenta44.95
Pons16.45
PrefrontalCortex176.05
Prostate131.7
Salivarygland88.35
SkeletalMuscle1032.2
Skin152.55
SmoothMuscle23.5
Spinalcord130.3
SubthalamicNucleus33.25
SuperiorCervicalGanglion18.2
TemporalLobe25.65
Testis11
TestisGermCell38.2
TestisIntersitial9.65
TestisLeydigCell13.75
TestisSeminiferousTubule31.55
Thalamus52.45
Thymus94.35
Thyroid164.85
Tongue30.4
Tonsil128.55
Trachea111.15
TrigeminalGanglion30.35
Uterus270.55
UterusCorpus47.1
WholeBlood936.55
Wholebrain118.4
colon27.5
pineal_day185.98
pineal_night95.46
retina334.075
small_intestine32.25
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_15597_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.59 ± 0.57
Basal Forebrain5.54 ± 0.35
Basal Part of Pons5.22 ± 0.33
Cerebellar Cortex5.92 ± 0.24
Cerebellar Nuclei5.61 ± 0.37
Claustrum5.79 ± 0.72
Epithalamus5.77 ± 0.4
Frontal Lobe5.35 ± 0.52
Globus Pallidus5.91 ± 0.53
Hypothalamus5.46 ± 0.63
Insula5.17 ± 0.52
Limbic Lobe5.46 ± 0.57
Mesencephalon5.5 ± 0.63
Myelencephalon5.49 ± 0.49
Occipital Lobe5.43 ± 0.5
Parietal Lobe5.54 ± 0.47
Pontine Tegmentum5.48 ± 0.6
Striatum4.81 ± 0.41
Subthalamus5.32 ± 0.37
Temporal Lobe5.26 ± 0.46
Thalamus5.57 ± 0.44
White Matter5.87 ± 0.55
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Bcl6CBCerebellum78.2
95.61
Bcl6CTXCerebral cortex72.31
53.03
Bcl6HIPHippocampal region72.9
100
Bcl6HPFHippocampal formation78.87
93.02
Bcl6HYHypothalamus49.61
30.8
Bcl6LSXLateral septal complex34.96
21.75
Bcl6MBMidbrain47.57
34.59
Bcl6MYMedulla60.72
60.64
Bcl6OLFOlfactory bulb100
93.83
Bcl6PPons50.31
45.14
Bcl6PALPallidum41.65
29.02
Bcl6RHPRetrohippocampal region87.43
76.27
Bcl6sAMYStriatum-like amygdalar nuclei49.97
31.23
Bcl6STRStriatum35.35
20.49
Bcl6STRdStriatum dorsal region26.74
14.06
Bcl6STRvStriatum ventral region53.79
31.33
Bcl6THThalamus37.93
23.67
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
BCL6_HUMAN_29 12 29 40 DILTDVVIVVSR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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