AutismKB 2.0

Annotation Detail for EDA2R


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Basic Information Top
Gene Symbol:EDA2R ( EDA-A2R,EDAA2R,TNFRSF27,XEDAR )
Gene Full Name: ectodysplasin A2 receptor
Band: Xq12
Quick LinksEntrez ID:60401; OMIM: 300276; Uniprot ID:TNR27_HUMAN; ENSEMBL ID: ENSG00000131080; HGNC ID: 17756
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body4 / 7076156
blastocyst2 / 6231932
fetus6 / 56401210
neonate2 / 3109764
infant0 / 236200 
juvenile0 / 555560 
adult15 / 19391217
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor3 / 9417831
cervical tumor0 / 343660 
chondrosarcoma1 / 8282312
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor4 / 26384515
glioma0 / 1068830 
head and neck tumor2 / 13630214
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal31 / 33603079
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS1 / 1256807
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone1 / 7165513
bone marrow0 / 488010 
brain8 / 11009897
cervix0 / 481710 
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue8 / 21572237
esophagus0 / 202090 
eye0 / 2110540 
heart0 / 896260 
intestine0 / 2344720 
kidney2 / 2117779
larynx0 / 241450 
liver3 / 20774314
lung4 / 33697411
lymph0 / 442700 
lymph node0 / 916100 
mammary gland3 / 15327119
mouth0 / 670520 
muscle1 / 1077159
nerve0 / 157680 
ovary0 / 1020510 
pancreas2 / 2148129
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate0 / 1893450 
salivary gland0 / 201550 
skin4 / 21057418
spleen0 / 539520 
stomach0 / 966190 
testis1 / 3304423
thymus2 / 8113124
thyroid2 / 4747342
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus1 / 2328784
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 221399_at
Cell line Expression level Expression bar
721_B_lymphoblasts7.1
Adipocyte6.4
AdrenalCortex8.05
Adrenalgland5.45
Amygdala6.55
Appendix7.05
AtrioventricularNode5.85
BDCA4+_DentriticCells6.3
Bonemarrow6.5
BronchialEpithelialCells6.2
CD105+_Endothelial6.4
CD14+_Monocytes6.7
CD19+_BCells(neg._sel.)6.55
CD33+_Myeloid7.55
CD34+7.4
CD4+_Tcells6.4
CD56+_NKCells6.9
CD71+_EarlyErythroid6
CD8+_Tcells5.7
CardiacMyocytes8.2
Caudatenucleus5.75
Cerebellum5.7
CerebellumPeduncles7.35
CiliaryGanglion5.25
CingulateCortex6.55
Colorectaladenocarcinoma6.4
DorsalRootGanglion10.2
FetalThyroid6.25
Fetalbrain6.4
Fetalliver8.6
Fetallung5.35
GlobusPallidus4.8
Heart8.1
Hypothalamus6.6
Kidney5.45
Leukemia_chronicMyelogenousK-5625.8
Leukemia_promyelocytic-HL-605.6
Leukemialymphoblastic(MOLT-4)5.15
Liver9.9
Lung7.05
Lymphnode5.55
Lymphoma_burkitts(Daudi)8.15
Lymphoma_burkitts(Raji)9.7
MedullaOblongata5.85
OccipitalLobe5.65
OlfactoryBulb5.05
Ovary7.4
Pancreas6.9
PancreaticIslet7.3
ParietalLobe6.8
Pituitary7.5
Placenta6.55
Pons7.1
PrefrontalCortex7.45
Prostate7.55
Salivarygland5.6
SkeletalMuscle9.9
Skin8.85
SmoothMuscle8.35
Spinalcord6.75
SubthalamicNucleus5.85
SuperiorCervicalGanglion15.2
TemporalLobe6.05
Testis5.55
TestisGermCell4.95
TestisIntersitial5.35
TestisLeydigCell6.35
TestisSeminiferousTubule5.65
Thalamus6.5
Thymus5.35
Thyroid8.1
Tongue8.75
Tonsil6.45
Trachea6.05
TrigeminalGanglion6.8
Uterus5.15
UterusCorpus6.25
WholeBlood7.2
Wholebrain5.45
colon6.25
pineal_day7.52
pineal_night7.38
retina7.525
small_intestine5.85
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_6776_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala1.93 ± 1
Basal Forebrain1.43 ± 0.19
Basal Part of Pons1.32 ± 0.45
Cerebellar Cortex1.34 ± 0.66
Cerebellar Nuclei1.78 ± 0.7
Claustrum2.4 ± 0.88
Epithalamus1.27 ± 0.73
Frontal Lobe1.41 ± 0.65
Globus Pallidus2.24 ± 0.4
Hypothalamus1.55 ± 0.65
Insula1.41 ± 0.5
Limbic Lobe1.54 ± 0.6
Mesencephalon1.68 ± 0.67
Myelencephalon1.58 ± 0.65
Occipital Lobe1.56 ± 0.62
Parietal Lobe1.56 ± 0.72
Pontine Tegmentum1.58 ± 0.67
Striatum1.74 ± 0.5
Subthalamus1.78 ± 0.75
Temporal Lobe1.41 ± 0.53
Thalamus1.5 ± 0.6
White Matter2.75 ± 1.3
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Eda2rCBCerebellum4.57
5.3
Eda2rCTXCerebral cortex7.99
5.78
Eda2rHIPHippocampal region5.14
4.39
Eda2rHPFHippocampal formation6.96
5.56
Eda2rHYHypothalamus3.19
2.35
Eda2rLSXLateral septal complex0.63
0.44
Eda2rMBMidbrain2.66
2.44
Eda2rMYMedulla7.21
8.03
Eda2rOLFOlfactory bulb6.89
4.63
Eda2rPPons4.16
4.61
Eda2rPALPallidum4.74
3.85
Eda2rRHPRetrohippocampal region10.79
7.75
Eda2rsAMYStriatum-like amygdalar nuclei4.08
2.75
Eda2rSTRStriatum1.96
1.37
Eda2rSTRdStriatum dorsal region1.75
1.34
Eda2rSTRvStriatum ventral region1.93
1.09
Eda2rTHThalamus2.76
2.05
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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