AutismKB 2.0

Annotation Detail for EXOC4


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Basic Information Top
Gene Symbol:EXOC4 ( MGC27170,REC8,SEC8,SEC8L1,Sec8p )
Gene Full Name: exocyst complex component 4
Band: 7q33
Quick LinksEntrez ID:60412; OMIM: 608185; Uniprot ID:EXOC4_HUMAN; ENSEMBL ID: ENSG00000131558; HGNC ID: 30389
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body5 / 7076170
blastocyst6 / 6231996
fetus87 / 564012154
neonate2 / 3109764
infant4 / 23620169
juvenile6 / 55556107
adult91 / 193912146
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor5 / 9417853
cervical tumor1 / 3436629
chondrosarcoma6 / 8282372
colorectal tumor11 / 11424696
esophageal tumor2 / 17290115
gastrointestinal tumor3 / 11936925
germ cell tumor20 / 26384575
glioma1 / 1068839
head and neck tumor7 / 13630251
kidney tumor6 / 6895987
leukemia4 / 9584241
liver tumor2 / 9635920
lung tumor3 / 10312729
lymphoma4 / 7175555
non-neoplasia3 / 9725030
normal223 / 336030766
ovarian tumor2 / 7668226
pancreatic tumor3 / 10461628
primitive neuroectodermal tumor of the CNS10 / 12568079
prostate cancer8 / 10268077
retinoblastoma2 / 4635643
skin tumor10 / 12494980
soft tissue/muscle tissue tumor4 / 12519131
uterine tumor4 / 9025744
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites2 / 4001549
bladder0 / 297570 
blood4 / 12347832
bone5 / 7165569
bone marrow0 / 488010 
brain131 / 1100989118
cervix1 / 4817120
connective tissue8 / 14925553
ear0 / 162120 
embryonic tissue12 / 21572255
esophagus2 / 2020998
eye14 / 21105466
heart1 / 8962611
intestine13 / 23447255
kidney8 / 21177737
larynx1 / 2414541
liver11 / 20774352
lung14 / 33697441
lymph1 / 4427022
lymph node9 / 9161098
mammary gland7 / 15327145
mouth4 / 6705259
muscle1 / 1077159
nerve3 / 15768190
ovary3 / 10205129
pancreas6 / 21481227
parathyroid0 / 205390 
pharynx1 / 4132824
pituitary gland1 / 1658560
placenta3 / 28082510
prostate18 / 18934595
salivary gland1 / 2015549
skin11 / 21057452
spleen2 / 5395237
stomach1 / 9661910
testis20 / 33044260
thymus5 / 8113161
thyroid2 / 4747342
tonsil0 / 169990 
trachea3 / 5241357
umbilical cord2 / 13680146
uterus10 / 23287842
vascular4 / 5178077
Microarray in BioGPS Top
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P135437
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.35 ± 0.68
Basal Forebrain6.65 ± 0.37
Basal Part of Pons6.85 ± 0.31
Cerebellar Cortex6.91 ± 0.36
Cerebellar Nuclei6.32 ± 0.62
Claustrum6.27 ± 0.56
Epithalamus6.98 ± 0.31
Frontal Lobe6.88 ± 0.38
Globus Pallidus6.02 ± 0.14
Hypothalamus6.91 ± 0.32
Insula7.01 ± 0.36
Limbic Lobe6.68 ± 0.5
Mesencephalon6.63 ± 0.55
Myelencephalon6.62 ± 0.52
Occipital Lobe6.13 ± 0.53
Parietal Lobe6.61 ± 0.42
Pontine Tegmentum6.56 ± 0.61
Striatum6.1 ± 0.42
Subthalamus6.37 ± 0.41
Temporal Lobe6.9 ± 0.41
Thalamus6.57 ± 0.33
White Matter6.36 ± 0.45
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Exoc4CBCerebellum33.07
59.91
Exoc4CTXCerebral cortex99.17
88.81
Exoc4HIPHippocampal region72.72
100
Exoc4HPFHippocampal formation82.23
100
Exoc4HYHypothalamus22.3
19.85
Exoc4LSXLateral septal complex45.13
36.33
Exoc4MBMidbrain44.48
47.37
Exoc4MYMedulla59.31
81.42
Exoc4OLFOlfactory bulb75.42
77.01
Exoc4PPons56.39
67.06
Exoc4PALPallidum41.4
42.05
Exoc4RHPRetrohippocampal region93.4
96.56
Exoc4sAMYStriatum-like amygdalar nuclei36.43
31.26
Exoc4STRStriatum51.38
41.99
Exoc4STRdStriatum dorsal region50.67
41.28
Exoc4STRvStriatum ventral region66.74
52.74
Exoc4THThalamus46.61
48.64
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
EXOC4_HUMAN_19 11 19 29 DPSGLLISVIR PRIDE
EXOC4_HUMAN_2 10 2 11 AAEAAGGKYR PRIDE
PAp00028405 12 784 795 VHCFHYLIPLAK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018